Podcast CME Course Information

Exam: Exam 146

Issue: September 4, 2012

Learning Objectives

Frontotemporal dementia due to C90RF72 mutations: Clinical and imaging features

C90RF72 repeat expansion in clinical and neuropathological frontotemporal dementia cohorts

Upon completion of this podcast, the participant will be able to discuss what characteristics of FTD are suggestive of the C90RF72 mutation.

Recommended Audience

This program is designed for physicians who are involved in providing patient care and who wish to advance their current knowledge of clinical medicine.

Core Competencies

• Medical Knowledge

Disclosures

Program Accreditation and Development Subcommittee (PADS) is responsible for reviewing and evaluating all CME programs. PADS members: Pradeep K. Sahota MD, FAAN, has nothing to disclose, Allison Brashear MD, FAAN, has received personal compensation for activities with Allergan, Merz, Ipsen and Osmotica as a consultant, has received personal compensation in an editorial capacity for Wemove, has received research support from Allergan, Merz, and Ipsen, J. Clay Goodman MD, FAAN, has nothing to disclose, Steven L. Lewis MD, FAAN, has received personal compensation in an editorial capacity for the journal Neurology, Barbara F. Westmoreland MD, FAAN, has nothing to disclose, Susan Rodmyre, has nothing to disclose.

Robert A. Gross, MD, PhD, FAAN has received research funding from the Department of the Army and UCBPharma. He is supported for educational endeavors from the University of Rochester Medical Center’s Clinical and Translational Science Award from the NIH. Dr. Gross has conducted clinical trials over the past five years funded by GlaxoSmithKline, UCB, Ortho-McNeil, Pfizer, and Marinus. He has served on the speakers’ bureaus for Abbott, UCB, and GlaxoSmithKline and has received consultant fees from GlaxoSmithKline and Harris Interactive. Since his appointment as Editor-in-Chief, Dr. Gross has ceased participation in industry-sponsored clinical trials and speakers’ bureaus. He receives an honorarium from AAN as Editor-in-Chief of Neurology.

Dr. Ted Burns serves as Podcast Editor for Neurology®; performs EMG studies in his neuromuscular practice (35% effort); and has received research support for consulting activities with CSL Behring and Alexion Pharmaceuticals. AAN staff members editing the test (P Baskin, L Kleffman) have no disclosures. The CME Journal Editors, who have reviewed the exam, are Steven Lewis MD, who receives a stipend in his editorial capacity for Neurology, and James WM Owens Jr. MD PhD, who receives royalties from UpToDate, Waltham, MA; grant support from NIH (PI, K08NS054882); and a stipend in his editorial capacity for Neurology.

Dr. Dobson-Stone receives research funding from the National Health and Medical Research Council (Australia). Dr. Clardy serves on the editorial team for the Neurology® Resident and Fellow Section. Dr. Bruce received research funding from the NIH. Dr. Kardon serves on the editorial board for Journal of Neuro-ophthalmology and Archives of Ophthalmology; has patents for method of characterizing focal pupil responses to light and method of assessing retinal function using infrared optical signals in response to light; receives royalties for the publication of 'Tissues and Organs: A text-atlas of scanning electron microscopy' and for use of micrographs in other textbooks; is a consultant for Novartis Pharmaceuticals Ltd; receives research support from the Department of Veterans Affairs Iowa City Center of Excellence for the Prevention and Treatment of Visual Loss, Department of Defense Vision Research Program (TATRC) and Department of Veterans Affairs Rehabilitation Division.

The other participants had nothing to disclose.

CME Expiration

CME expires three years after publication date or sooner if podcasts are deemed out of date by reviewers.

Accreditation

The American Academy of Neurology is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

AMA PRA Credit™

The American Academy of Neurology designates that participants will receive 0.5 AMA PRA Category 1 CME credits™ by answering the multiple-choice questions in the online Podcast quiz.

Copyright

The American Academy of Neurology holds copyright for all materials in this exam.

Confidentiality

Any information regarding the identity of individuals taking the exam or their exam scores will be kept confidential.

Hardware and Software Requirements

A computer with a web browser such as Internet Explorer, Firefox, Safari, or Google Chrome is required.

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