| From the Editor's Desk |
championing advocacy: changes start with us.
Pages: 1
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| The Nerve! Readers Speak |
seeking practical advice.
- McLeod, Nancy. Pages: 2-3
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| Clinical and Ethical Challenges |
hemiparkinsonism after unilateral traumatic midbrain hemorrhage in a young woman.
- Harik, Sami, Al-Hinti, Jomana, Archer, R., Angtuaco, Edgardo. Pages: 4-7
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Summary: The relationship between head trauma and parkinsonism has been debated since James Parkinson's first description of the shaking palsy in the late 19th century. We observed in our outpatient clinic a young woman in whom hemiparkinsonism developed within 3 weeks of sustaining closed head trauma with loss of consciousness. The patient had a discrete unilateral midbrain hemorrhage on head MRI which involved the contralateral substantia nigra. The condition responded well to carbidopa/levodopa. This patient is a convincing example of posttraumatic midbrain hemorrhage causing parkinsonism.(C)2013AAN Enterprises, Inc.
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emg/ncs in the evaluation of spine trauma with radicular symptoms.
- Charles, James, MD, FAAN, Souayah, Nizar. Pages: 8-14
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Summary: In the management of spine trauma with radicular symptoms (STRS), EMG/nerve conduction studies (NCS) often have low combined sensitivity and specificity in confirming root injury. The anatomic level of injury may not correspond to the root level. Paraspinal studies are nonlocalizing and can be falsely positive and negative. Unlike MRI and CT imaging, EMG/NCS do not reveal the biological morphology of the lesion. There are no studies that confirm the efficacy of EMG/NCS in the management of STRS. EMG/NCS may be indicated if there is a differential diagnosis between a root and distal neuropathic/myopathic lesion. Otherwise, as shown in this series of cases typically referred for outpatient EMG/NCS testing, there is limited evidence to support the use of often uncomfortable and costly EMG/NCS in STRS.(C)2013AAN Enterprises, Inc.
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restricted diffusion preceding gadolinium enhancement in large or tumefactive demyelinating lesions.
- Hyland, Megan, Bermel, Robert, Cohen, Jeffrey. Pages: 15-21
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Summary: Although restricted diffusion without coincident contrast enhancement is most commonly associated with cerebral ischemia, large or tumefactive multiple sclerosis (MS) lesions may demonstrate this pattern initially, followed by subsequent gadolinium (Gd) enhancement. The clinical and MRI characteristics of 3 patients with MS with this imaging pattern are reviewed. All patients had brain MRI lesions >1 cm in diameter, in locations consistent with new neurologic symptoms, and with prominent restricted diffusion but no Gd enhancement. Demyelinating lesion etiologies were supported by CSF findings, laboratory exclusion of alternative diagnoses, lesion evolution, or additional lesions characteristic of MS on brain MRI. Follow-up imaging within 2-4 weeks showed decreased restricted diffusion with patchy Gd enhancement which resolved on subsequent imaging. This imaging evolution may reflect early demyelination prior to inflammation-associated blood-brain barrier disruption.(C)2013AAN Enterprises, Inc.
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| Five New Things |
non-parkinson movement disorders: five new things.
- LeDoux, Mark, MD, PhD. Pages: 22-29
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Summary: Solutions to the major riddles in movement disorders are appearing at a breathtaking pace: 1) loss-of-function mutations in PRRT2, which encodes a cell surface protein expressed in neurons, have been found in many patients with paroxysmal kinesigenic dyskinesias; 2) mutations in CIZ1, which encodes a protein involved in cell-cycle control at the G1-S checkpoint, have been identified in a small percentage of patients with cervical dystonia; and 3) finally, after many years of genetics and identification of more than 25 disease-associated genes, cellular studies related to the pathobiology of hereditary spastic paraplegia are converging on defects in modeling the endoplasmic reticulum and membrane trafficking. On the treatment front, the distinctive syndromes of faciobrachial dystonic seizures with anti-LRI1 antibodies and anti-N-methyl-D-aspartic acid encephalitis with orobuccolingual dyskinesias are becoming increasingly recognized by clinicians as imminently treatable conditions. Also on the treatment front, the first phase I trial of MRI-guided high-intensity focused ultrasound for essential tremor has been completed and intraoperative MRI is currently being used to place electrodes in the brains of patients with medically intractable dystonia. Definitive etiologies and efficacious treatments for non-Parkinson disease movement disorders are no longer wishful thinking.(C)2013AAN Enterprises, Inc.
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neurology and the military: five new things.
- Tsao, Jack, MD, DPhil, Alphonso, Aimee, Griffin, Sarah, Yurkiewicz, Ilana, Ling, Geoffrey, MD, PhD. Pages: 30-38
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Summary: The current Iraq and Afghanistan conflicts have seen the highest survival rates in US service members ever, despite staggering numbers of traumatic brain injury and limb loss cases. The improvement in survival can be attributed at least in part to advances in far-forward, rapid medical treatment, including the administration of hypertonic saline solutions and decompressive craniectomies to manage elevated intracranial pressure. After evacuation to military hospitals in the continental United States, service members who have had limb loss face extensive rehabilitation. The growing amputee population has led to a burgeoning interest in the treatment of phantom limb pain and in the development of advanced prostheses.(C)2013AAN Enterprises, Inc.
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| Eye on Practice |
a personal journey in advocacy.
- Henson, Lily, Jung MD, MMM, May, Eugene. Pages: 39-43
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Summary: Over the past decade, neurology advocacy has caught the attention of neurologists feeling increasingly frustrated about the health care environment in which they practice. We describe our experience in practicing advocacy at the national and local levels. Neurologists can participate in many levels of advocacy to benefit their patients and their profession.(C)2013AAN Enterprises, Inc.
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quality measures for neurologists: financial and practice implications.
- Cohen, Adam, Sanders, Amy, MD, MS, Swain-Eng, Rebecca, Gjorvad, Gina, Tonn, Sarah, Bever, Christopher, Jr MD, MBA, Cheng, Eric, MD, MS. Pages: 44-51
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Summary: Measuring and reporting health care quality is increasingly becoming part of clinical practice and reimbursement for specialists, including neurologists. The goal is to improve the value of care. Current major programs tie quality measurements to reimbursement, including programs from the Centers for Medicare and Medicaid Services: the Physician Quality Reporting System, the Electronic Health Record Incentive Program (and Meaningful Use), and Accountable Care Organizations. Many specialty boards, including the American Board of Psychiatry and Neurology, now require clinical practice quality measurements for maintenance of certification. Practitioners may find these programs confusing, overlapping, burdensome, and not clearly relevant to promoting better patient care. Yet, integrating quality metrics into practice has entered the mainstream and is increasingly tied to reimbursement. Further, over the next few years, most programs will switch from bonus incentives for participation to penalties for nonparticipation. This article aims to clarify current and rising quality measurement programs relevant to neurologists.(C)2013AAN Enterprises, Inc.
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mobile medical applications in neurology.
- Cohen, Adam, Nahed, Brian, Sheth, Kevin. Pages: 52-60
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Summary: Smartphone or mobile applications (apps) are increasingly used in clinical practice. Apps have evolved from electronic pocket references to interactive utilities, ranging from dynamic visual references, interactive and analytic clinical tools, remote desktops, and scheduling and communication platforms. Additionally, apps designed for patient monitoring, advising, data collection, and documentation are useful for clinicians, researchers, and patients. This report aims to provide an introduction to several valuable mobile apps for neurologists and students of neurology.(C)2013AAN Enterprises, Inc.
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supreme court decision on the affordable care act: what does it mean for neurology?.
- Jones, Elaine, MD, FAAN. Pages: 61-66
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Summary: In March 2010, President Obama signed into law the Patient Protection and Affordable Care Act (the Act or ACA), which is felt to be the most comprehensive reform to health care in the United States since the enactment of Medicare/Medicaid in 1965. Nothing this big happens overnight and without controversy. Numerous concerns were raised from all demographics and from both sides of the political aisle. Some of the concerns were legal questions regarding constitutionality and so legal processes began to address this issue. In June 2012, the Supreme Court decided in a 5-4 vote that the Act is constitutional. This has allowed the legislation to stand and over the next few years the more transforming parts will start to be implemented. It is important to understand the issues surrounding the Supreme Court decision and the impact this may have on health care and specifically the practice of neurology.(C)2013AAN Enterprises, Inc.
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| Drugs and Devices |
alternative devices for obstructive sleep apnea.
- Barone, Daniel. Pages: 67-70
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Summary: Obstructive sleep apnea (OSA) is a relatively common condition which is most often treated with continuous positive airway pressure (CPAP). Given the compliance issues associated with CPAP, it is important for neurologists (and anyone who treats OSA) to be aware of what other treatment devices exist for this disease. This article reviews mandibular advancement devices, nasal expiratory airway pressure devices, hypoglossal nerve stimulators, and oral pressure therapy devices in terms of their mechanism of action, efficacy, and practicality.(C)2013AAN Enterprises, Inc.
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| Current Controversies |
formularies, costs, and quality of care: formulary restrictions are not the answer, especially for epilepsy.
- Labiner, David, Drake, Kendra. Pages: 71-74
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formularies, costs, and quality of care: limiting formularies is not harmful to patients.
- Jones, William, MS, RPh. Pages: 75-77
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| Cases |
artificial pearls in the brain.
- Takeda, Ririko, Kurita, Hiroki, MD, PhD. Pages: 78-79
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the man with hemi-cape dysesthesias.
- Leon-Guerrero, Christopher, Morgenlander, Joel. Pages: 80-81
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brain and spinal manifestations of miller-dieker syndrome.
- Hsieh, David, Jennesson, Melanie, Thiele, Elizabeth, MD, PhD, Caruso, Paul, Masiakos, Peter, MS, MD, Duhaime, Ann-Christine. Pages: 82-83
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topographic disorientation following mesial left temporo-occipital hemorrhage.
- Chahine, Lama. Pages: 84-85
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