Abstract Details

Title The Relationship of Continous 24-Hour Admission Blood Pressure To Severity and Short-Term Outcome Amongst Stroke Patients At The University of Abuja Teaching Hospital, Abuja, Nigeria.

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P6 - Poster Session 6 (12:00 PM-1:00 PM)

Poster/Presentation
Number 4-015

Background Admission blood pressure (BP) is a major determinant of stroke severity and short-term outcome following all strokes. Accurate assessment of blood pressure in the acute post stroke period is crucial for proper stroke management.

Objective

To determine the relationship of continuous 24-hour admission blood pressure to stroke severity and 30-days’ mortality and functional outcome amongst survivors in acute ischemic stroke (AIS) and intracerebral hemorrhage (ICH).

Design/Methods 63 AIS and 77 ICH patients were assessed within 72-hours of event with continuous ambulatory blood pressure monitors (ABPM-50) to generate 24-hour blood pressure recordings. Admission NIH Stroke Score determined severity (NIHSS ≥ 15 defined severe stroke) and outcome by 30-day case fatality or by independence amongst stroke survivors according to Modified Rankin Scale (MRS > 3 defined unfavorable outcome).

Results

24-hour continuous blood pressure variables (CBPV) were higher and showed significant and positive correlation to stroke severity in ICH patients but significantly inverse and lower CBPV in AIS

All CBPV were significantly higher in ICH but lower in AIS patients with poor outcome expressed as 30-day mortality. However, of these CBPV, Average-(Avr) day-time DBP [odds ratio (OR), 0.944; 95% confidence interval (CI), 0.893–0.998], Minimum 24-hour SBP [OR, 0.872; 95% CI, 0.779 – 0.981] and Minimum 24-hour DBP [OR, 1.148; 95% CI, 1.010 - 1.304] in AIS and Maximum 24-hour DBP [OR, 0.996; 95% CI, 0.996 - 1.115] in ICH significantly predicted mortality.

No CBPV predicted independence at 30-days in either AIS or ICH, however a non-significant trend with unfavorable functional outcome was observed with elevated CBPV in ICH and lower CBPV in AIS.

Conclusions

In addition to the prognostic significance of continuous blood pressure measures in stroke outcome, individual blood pressure variables may become potential targets for anti-hypertensive intervention.

Authors/Disclosures
Ifeyinwa Ani-Osheku, MBBS (Dept of Internal Medicine) PRESENTER	Dr. Ani-Osheku has nothing to disclose.
Mustapha A. Danesi, MD (Medical Tutors limited)	No disclosure on file
Njide Okubadejo, MD, FAAN (University of Lagos)	No disclosure on file
Peter Alabi, Sr., MBBS, FMCP (Pseven Medical diagnostics and Consulting Centre Limited)	Dr. Alabi has received personal compensation in the range of $0-$499 for serving as an officer or member of the Board of Directors for Norvatis.