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Abstract Details

Prevalence of Pulmonary Diseases in Patients with a History of Epilepsy/Seizures
Epilepsy/Clinical Neurophysiology (EEG)
P6 - Poster Session 6 (12:00 PM-1:00 PM)
12-007

The functions of the respiratory system and central nervous are inherently interdependent. Pulmonary diseases may cause hypoxia, which can result in an epileptogenic injury to areas sensitive to oxygen deprivation, such as the hippocampus, which can lower the seizure threshold. Chronic Obstructive Pulmonary Disease (COPD) could be an independent risk factor for stroke-related and hypoxia-induced seizures. Also, sedentary lifestyle of some patients with E/S can increase risk of venous thromboembolism (VTE).

To describe the prevalence of common pulmonary diseases in patients with a history of epilepsy/seizures (E/S).

This study was conducted at King Abdullah University Hospital, Jordan. All adult persons (> 18 years) who had a history of E/S between 2012 and 2018 were included. We calculated the prevalence of common pulmonary diseases in this cohort of patients and compared that with an age- and gender-matched cohort of patients who had no history of E/S (NON-E/S) and visited the neurology outpatient clinic during the same period of time.

A total of 937 patients were included in the study with a mean age of 47 ± 19.7 years (males 53.1%). 726 (77.5%) patients had history of E/S. Comparing E/S with NON-E/S patients, the prevalence of COPD was 1.1% versus 0.5% (P= 0.41); asthma was 1.2% versus 1.9 % (P= 0.47); obstructive sleep apnea was 0.3% versus 0.5% (P= 0.65); and VTE was 4% versus 0.9% (P=0.029, OR 4.35, 95% CI 1.03-18.37).

This study suggests that VTE is significantly higher in patients with E/S. These preliminary findings should be further studied. Meanwhile, this increased risk should be considered in this population.

 

 

Note: another abstract ID:4854 titled “PREVALENCE OF CARDIOVACULAR DISEASES AND VASCULAR RISK FACTORS IN PATIENTS WITH HISTORY OF EPILEPSY/SEIZURES” by my colleague, Dr. Ahmed Yassin, was submitted to AAN 2020 meeting on the same cohort of patients with different disease focus

Authors/Disclosures
Khalid I. El-Salem, MD, FAAN (Jordan University of Science and Technology)
PRESENTER
Dr. El-Salem has nothing to disclose.
Abdel-Hameed Al-Mistarehi (Jordan University of Sceince and Technology (JUST)) Mr. Al-Mistarehi has nothing to disclose.
Ahmed Moh'd Yassin, MD (Jordan University of Science and Technology) Dr. Yassin has nothing to disclose.
Saba Sari Mohidat, Jr., MD Dr. Mohadat has nothing to disclose.
Ahmad al Omari No disclosure on file
Ehab Yaser Khaled Harahsheh, MBBS (Mayo Clinic College of Medicine) Dr. Harahsheh has nothing to disclose.
Omar Telfah No disclosure on file
Christina Hanania, MBBS (UW Health) No disclosure on file
Raya Abughanmi No disclosure on file
Yara Abukariem No disclosure on file
Majd mo’adi No disclosure on file
Basheer Khassawneh Basheer Khassawneh has nothing to disclose.