Abstract Details

Title Clinical correlates of Body Mass Index in Mexican patients with Huntington’s disease

Topic Movement Disorders

Presentation(s) P6 - Poster Session 6 (12:00 PM-1:00 PM)

Poster/Presentation
Number 3-013

Background

Body weight has received special attention, since weight loss has been found correlated to female sex, CAG repeat number and disease progression but unrelated to disease severity.

Objective Evaluate the clinical correlates of body mass index in Mexican patients with HD.

Design/Methods Patients with manifest diagnosis of Huntington’s disease who attended the outpatient neurology clinic from March 2018 to April 2019 were recruited. Severity of disease was assessed with the Unified Huntington’s Disease Rating Scale-Total Motor Score (UHDRS-TMS), and functional status with Myers rating scale. Nutritional status was evaluated through Body Mass Index (BMI), following the criteria of the world health organization (WHO). For our main objective, the UHDRS-TMS and Myers score were compared between BMI groups using Mann-Whitney’s U test or Kruskall-Wallis test where appropriate. Bivariate correlations were sought between BMI as a continuous variable and UHDRS-TMS and Myers score. A p<0.05 was considered significant.

Results Twenty-eight patients were included, average age of patients with HD was 48 ± 17 years. 51,7% were female. For the variable of BMI, it was found that 50,0% (n=14) of the patients presented normal weight, 32,1% (n=9) underweight and 17,9% (n=5) overweight and obesity. Female patients were significantly more overweight (p= 0.014), and non-significantly underweight. Overweight patients, had lower severity scores according to UHDRS-TMS (p=0.738). Whereas functional impairment measured with Myers scale revealed similar results. BMI was significantly correlated with oral, gait and dystonia domains of UHDRS-TMS.

Conclusions These results are useful for the development of new research to improve nutritional status on patients and assure a good quality of life.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
Denisse G. Martinez Roque, Jr. (Universidad Autonoma de San Luis Potosí)	Miss Martinez Roque has nothing to disclose.
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file