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Abstract Details

Static and Dynamic Functional Connectivity Differences in Migraine compared to Healthy Controls
Headache
Headache Posters (7:00 AM-5:00 PM)
057

Migraine patients have alterations in static fc in regions involved with pain-processing. However, differences in dynamic fc, which measures how connectivity between regions fluctuates over time are insufficiently understood in migraine.

To interrogate differences in static and dynamic resting-state functional connectivity (rs-fc) between migraine patients and healthy controls, and to determine whether rs-fc associates with migraine burden (headache frequency, years lived with migraine) and hypersensitivity symptoms (cutaneous allodynia, photosensitivity, phonosensitivity).

Static and dynamic rs-fc for 65 migraine patients and 64 age- and sex-balanced healthy controls were assessed for 67 regions of interest that are involved in pain-processing. Relationships between abnormal rs-fc with migraine burden and hypersensitivity symptoms were explored.

Patients with migraine had weaker static and more variability in dynamic fc between regions of the pain-matrix. No overlap was found between static and dynamic region-to-region alterations. For migraine patients, there was a 1) negative relationship between hyperacusis and static ventromedial prefrontal-parieto-occipital fc; 2) positive relationship between headache frequency and middle frontal-cuneus dynamic fc; 3) positive relationship of headache frequency with hypothalamus-amygdala and hypothalamus-primary somatosensory dynamic fc. Post-hoc comparisons revealed stronger static and fluctuating dynamic visual network connectivity in migraine with aura compared to migraine without aura.

Migraine is associated with weaker static rs-fc and altered dynamic rs-fc amongst regions commonly involved in pain-processing. In migraine there were significant associations between static fc with hyperacusis and between dynamic fc with headache burden. The unique patterns of static and dynamic fc aberrations in migraine suggest that they measure different neurophysiological properties of migraine. Post-hoc comparisons between MwA and MwoA show fc alterations in the visual processing stream potentially indicating that aura may alter static and dynamic visual network connectivity.  

Authors/Disclosures
Catherine Daniela Chong, PhD, FAAN (Mayo Clinic)
PRESENTER
Dr. Chong has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for HCOP. The institution of Dr. Chong has received research support from AMGEN. The institution of Dr. Chong has received research support from Department of Defense. The institution of Dr. Chong has received research support from NIH. An immediate family member of Dr. Chong has received intellectual property interests from a discovery or technology relating to health care.
Gina Dumkrieger, PhD (Mayo Clinic) Gina Dumkrieger has received personal compensation for serving as an employee of Mayo Clinic. The institution of Gina Dumkrieger has received research support from NIH. The institution of Gina Dumkrieger has received research support from DOD. The institution of Gina Dumkrieger has received research support from AMGEN.
Katherine Ross (Phoenix VA Health Care System) Katherine Ross has nothing to disclose.
Visar Berisha Visar Berisha has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cytokinetics. Visar Berisha has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Boehringer Ingelheim. Visar Berisha has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for Aural Analytics. Visar Berisha has received stock or an ownership interest from Aural Analytics. The institution of Visar Berisha has received research support from Boheringer Ingelheim. Visar Berisha has received intellectual property interests from a discovery or technology relating to health care.
Todd J. Schwedt, MD, FAAN (Mayo Clinic) Dr. Schwedt has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Allergan. Dr. Schwedt has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biohaven. Dr. Schwedt has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Eli Lilly. Dr. Schwedt has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Lundbeck. Dr. Schwedt has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Satsuma. Dr. Schwedt has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biodelivery Science. Dr. Schwedt has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Abbvie. Dr. Schwedt has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Axsome. Dr. Schwedt has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Collegium. Dr. Schwedt has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Linpharma. Dr. Schwedt has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Theranica. Dr. Schwedt has received personal compensation in the range of $0-$499 for serving as a Consultant for Amgen. Dr. Schwedt has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Scilex. Dr. Schwedt has stock in Aural Analytics. Dr. Schwedt has stock in Nocira. The institution of Dr. Schwedt has received research support from Amgen. The institution of Dr. Schwedt has received research support from National Institutes of Health. The institution of Dr. Schwedt has received research support from United States Department of Defense. The institution of Dr. Schwedt has received research support from Patient Centered Outcomes Research Institute. The institution of Dr. Schwedt has received research support from SPARK Neuro. The institution of Dr. Schwedt has received research support from Henry Jackson Foundation. Dr. Schwedt has received intellectual property interests from a discovery or technology relating to health care. Dr. Schwedt has received publishing royalties from a publication relating to health care.