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Abstract Details

Temporal Trends & Outcomes Of Hospitalizations For Epilepsy With Aneurysmal Subarachnoid hemorrhage
Cerebrovascular Disease and Interventional Neurology
S6 - Cerebrovascular Disease: Diagnosis, Prediction, and Population Health (3:42 PM-3:54 PM)
Epilepsy is well known complication following aSAH , but data regarding incidence of epilepsy in this population is sparse.
To evaluate national estimate of trends and outcomes of epilepsy in aneurysmal subarachnoid hemorrhage (aSAH).
Nationwide Inpatient Sample (NIS) 2010-2014 utilized ICD-9 codes. Included patients ≥ 18 years, Excluded Traumatic aSAH and arteriovenous malformations. Hospitalization with Epilepsy identified using ICD-9CM code 345.xx in secondary diagnostic field, differences between categorical variables were tested using chi-square test and continuous variables using Student t-test. P values for trends were generated by Cochrane-Armitage test for categorical variables & simple linear regression for continuous variables.
Of 41,912 patients, 1,655 (4%) had incidence of epilepsy(Mean age 54.5 ± 15 years, 69.1% Female). aSAH-epilepsy group was associated with significantly higher incidence of comorbidities like CHF (9.9 % vs 5.2%), coagulopathy (10.6% vs 6%), Cerebral edema (32.5 % vs 24.3%) & complications such as neurological (35.9% vs 32.5%), Pulmonary (65.2% vs 48.2%), hematologic (43.6% vs 28.4%), & infectious (51.9% vs 37.4%). aSAH-epilepsy group were associated with Medicare/Medicaid insurance (51.3%) & at a teaching hospital (86.1%) (p <0.0001). In-hospital mortality with aSAH-epilepsy was 17.2 % vs 10.9% %, longer mean length of stay (23.9 vs 18.1 days, p <0.0001) & higher mean cost of hospitalization (112691$ vs 85987$, p <0.0001). Hospitalization for aSAH epilepsy increased from 3.8 % to 4.5 % in 2014 with upward trends in-hospital mortality (16.6% to 21.7%), mean length of stay (23.1 days to 24.3 days) & mean cost of hospitalization (from 101945 $ to 121,827 $ in 2014, p <0.0001). Multivariate analysis showed increased odds of mortality (OR:1.72, p=0.002) & longer length of stay (OR:2.31, p=0.0002).
There was higher upward trends in incidence of epilepsy during aSAH with higher in hospital mortality, longer length of stay & higher cost of hospitalization. It is imperative to consider that comorbid conditions lead to higher in-hospital complications. 
Parisha Bhatia
Dr. Bhatia has nothing to disclose.
No disclosure on file
Neena Viswanathan (Bluesky) Dr. Viswanathan has nothing to disclose.
Tejinder Singh (Reading Hospital- Towerhealth- Division of Neurology) Dr. Singh has nothing to disclose.
No disclosure on file