Vaccine administration has been associated with a wide variety of inflammatory mediated CNS demyelinating syndromes that usually appear few days following the immunization such as optic neuritis with encephalomyelitis such as MOGAD, ADEM, and NMOSD. Post-SARS-CoV-2 vaccination Optic Neuritis (ON) is an extremely rare adverse event with the incidence of post-vaccination ON being much lower than for ON alone. Most cases were reported post AstraZeneca vaccine, Pfizer-BioNTech and Sinovac. Autoantibodies against MOG were mostly detected. The condition is treated spontaneously and both steroid responsive and plasma exchange. The underlying mechanism in post vaccination ON is systemic autoimmune process in contrast to regular ON cases, which are predominantly Multiple Sclerosis linked. Majority of patients had no prior history of neuro-inflammation and the risk is higher with increasing age, women and with a history of autoimmune disease.