Abstract Details

Title Incidence and Predictors of in-hospital mortality associated with Status Epilepticus using Nationwide inpatient population cohort database (2011-2014)

Topic Epilepsy/Clinical Neurophysiology (EEG)

Presentation(s) P9 - Poster Session 9 (5:30 PM-6:30 PM)

Poster/Presentation
Number 10-002

Background Status Epilepticus (SE) is a life-threatening neurological emergency associated with higher mortality. We utilized NIS(Nationwide Inpatient sample) database to study trends and predictors of mortality associated with primary diagnosis of Status Epilepticus.

Objective To evaluate national estimate of incidence and predictors of in-hospital mortality associated with Status Epilepticus.

Design/Methods

Patients aged ≥ 18 years with primary diagnosis of Status epilepticus were identified from the Nationwide Inpatient Sample (NIS) from 2011 to 2014 using ICD-9 CM diagnosis code 345.2 and 345.3. Differences between categorical variables were tested using the chi-square test and continuous variables using the Student t-test. P values for trends were generated by Cochrane- Armitage test for categorical variables and simple linear regression for continuous variables.

Results

We identified 76,370 patients with primary diagnosis of status epilepticus (Mean age 52 ± 19 years, 52.3% male, 56.4% white) during our study period, of which 346 (0.45%) had Petit mal and 76024 had grand mal seizures. Multivariate analysis for predictors of mortality showed increasing age per year (OR:1.04, 95% CI:1.03-1.05, p<0.001), Higher comorbidity index (OR:1.19, 95% CI:1.14-1.24, p<0.001), co-morbidities such as Diabetes mellitus (OR:1.51, 95% CI:1.21-1.88, p<0.001), Chronic Kidney disease (OR:2.24, 95% CI:1.73-2.89, p<0.001), Chronic liver disease (OR:1.98, 95% CI:1.34-2.91, p=0.001), Fluid and electrolyte disturbance (OR:2.03, 95% CI:1.67-2.47, p<0.001), admission in a teaching hospital (OR:1.85, 95% CI:1.49-2.28, p<0.001) were predictors of increased mortality. African American (OR:0.66, 95% CI:0.51-0.85, p=0.001) and Hispanics (OR:0.60, 95% CI:0.41-0.89, p=0.010) patient population as compared to Caucasian were associated with decreased mortality.

Conclusions Co-morbidities such as Diabetes, chronic kidney disease, chronic liver disease, higher comorbidity index and increasing age were significant predictors of mortality in patients hospitalized with primary diagnosis of status epilepticus. Therefore, proactively addressing these co-morbidities during hospitalization may help in reducing mortality in this population.

Authors/Disclosures
Tejinder Singh, MD (Reading Hospital- Towerhealth- Division of Neurology) PRESENTER	Dr. Singh has nothing to disclose.
Parisha Bhatia, MD	Dr. Bhatia has nothing to disclose.
Neena Viswanathan, MD (Bluesky)	Dr. Viswanathan has nothing to disclose.
Varun Kumar, MD (Arrive Streeterville)	Dr. Kumar has nothing to disclose.
	No disclosure on file
	No disclosure on file
Chirag N. Savani, MD (Tampa General Hospital)	No disclosure on file