Abstract Details

Title Pregnancy in women with Neuromyelitis Optica Spectrum Disorders: Recommendations from the French Multiple Sclerosis Society

Topic Multiple Sclerosis

Presentation(s) P13 - Poster Session 13 (8:00 AM-9:00 AM)

Poster/Presentation
Number 12-006

Background In 2020, the French Multiple Sclerosis (MS) Society (SFSEP) decided to develop a national evidence-based consensus on pregnancy in MS. As NMOSD and MOG-antibody associated disease (MOGAD) share a series of commonalities with MS, and some significant differences about that topic, specific recommendations had to be developed.

Objective To establish recommendations on pregnancy in women with neuromyelitis optica spectrum disorders (NMOSD).

Design/Methods The French Group for Recommendations in Multiple Sclerosis (France4MS) reviewed articles from PubMed and universities databases (January 1975 through December 2020). The RAND/UCLA appropriateness method, which was developed to synthesize the scientific literature and expert opinions on health care topics, was used to reach a formal agreement. 58 MS experts worked on the full-text review and initial wording of recommendations. A sub-group of 9 NMOSD experts was dedicated to analyzing of available data on NMOSD and MOGAD. A group of multidisciplinary healthcare specialists validated the final proposal of summarized evidences.

Results A strong agreement was reached for all 66 proposed recommendations. They cover diverse topics, such as pregnancy planning, follow-up during pregnancy and in the post-partum, delivery routes, loco-regional analgesia or anesthesia, prevention of post-partum relapses, breastfeeding, vaccinations, reproductive assistance, management of relapses, and disease-modifying treatments. Details will be presented at the AAN congress.

Conclusions Physicians and patients should be aware of the new evidence-based recommendations of the French MS Society for pregnancy in women with NMOSD and MOGAD.

Authors/Disclosures
Sandra Vukusic, MD (Hopital Neurologique Pierre Wertheimer) PRESENTER	The institution of Dr. Vukusic has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. The institution of Dr. Vukusic has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. The institution of Dr. Vukusic has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. The institution of Dr. Vukusic has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. The institution of Dr. Vukusic has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Teva. The institution of Dr. Vukusic has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Celgene. The institution of Dr. Vukusic has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. The institution of Dr. Vukusic has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sandoz. Dr. Vukusic has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen.
Jonathan Ciron, MD (CHU Toulouse)	Jonathan Ciron, MD has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Jonathan Ciron, MD has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Jonathan Ciron, MD has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Merck. Jonathan Ciron, MD has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for BMS - Celgene. Jonathan Ciron, MD has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion.
Clarisse Carra-Dalliere	No disclosure on file
	No disclosure on file
	No disclosure on file
Emmanuelle Leray (EHESP)	No disclosure on file
Anne Marie Guennoc	Anne Marie Guennoc has nothing to disclose.
Bertrand Bourre	Bertrand Bourre has nothing to disclose.
David Laplaud	No disclosure on file
	No disclosure on file
Caroline Bensa	Caroline Bensa has nothing to disclose.
Kevin Bigaut	Kevin Bigaut has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Kevin Bigaut has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche.
Damien Biotti	Damien Biotti has nothing to disclose.
Pierre Branger	Pierre Branger has received personal compensation in the range of $500-$4,999 for serving as a Consultant for NOVARTIS. Pierre Branger has received personal compensation in the range of $0-$499 for serving as a Consultant for BIOGEN. Pierre Branger has received personal compensation in the range of $500-$4,999 for serving as a Consultant for MERCK. Pierre Branger has received personal compensation in the range of $500-$4,999 for serving as a Consultant for BMS.
Olivier Casez, MD (CHU De Grenoble)	Dr. Casez has nothing to disclose.
Mikael Cohen (Hopital Pasteur)	Mikael Cohen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen, Roche, Merck, Ad scientiam, Novartis, Alexion, BMS.
	No disclosure on file
	No disclosure on file
	No disclosure on file
Anne-Laure Dubessy	Anne-Laure Dubessy has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis.
	No disclosure on file
Francoise Durand Dubief (Hopital Pierre Wertheimer)	The institution of Francoise Durand Dubief has received research support from ARSEP.
Maxime Guillaume	Maxime Guillaume has nothing to disclose.
	No disclosure on file
Laurent D. Kremer	Laurent D. Kremer has nothing to disclose.
Arnaud Kwiatkowski (Hopital Saint Philibert)	Arnaud Kwiatkowski has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Arnaud Kwiatkowski has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Arnaud Kwiatkowski has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche . Arnaud Kwiatkowski has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Merck. Arnaud Kwiatkowski has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen .
Julien Lannoy	Julien Lannoy has nothing to disclose.
Adil Maarouf	Adil Maarouf has nothing to disclose.
Eric Manchon, MD (Hopital de Gonesse)	Eric Manchon, MD has nothing to disclose.
Guillaume Mathey	Guillaume Mathey has nothing to disclose.
Xavier Moisset	Xavier Moisset has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Allergan. Xavier Moisset has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Xavier Moisset has received personal compensation in the range of $500-$4,999 for serving as a Consultant for BMS-Celgene. Xavier Moisset has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Grunenthal. Xavier Moisset has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Lilly. Xavier Moisset has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Teva. Xavier Moisset has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck-Serono. Xavier Moisset has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Xavier Moisset has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Xavier Moisset has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sanofi-Aventis.
Alexis Montcuquet	Alexis Montcuquet has nothing to disclose.
	No disclosure on file
	No disclosure on file
Romain Marignier, MD, PhD (Lyon University Hospital)	Dr. Marignier has received personal compensation in the range of $0-$499 for serving as a Consultant for UCB. Dr. Marignier has received personal compensation in the range of $500-$4,999 for serving as a Consultant for ALEXION. Dr. Marignier has received personal compensation in the range of $500-$4,999 for serving as a Consultant for ROCHE. Dr. Marignier has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amgen. Dr. Marignier has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for ROCHE.
	No disclosure on file