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Abstract Details

Associations Between Inpatient mTBI Patient Cognitive Profile and Outpatient Functional Status at 6 Months Post-Injury, a University of California Davis Cognitive Screener (UCD-Cog) Study.
Neuro Trauma and Critical Care
P11 - Poster Session 11 (11:45 AM-12:45 PM)

The best method of identifying mTBI patients at risk of developing a persistent post-concussive syndrome, particularly during the acute post-injury phase, is a matter of ongoing research.  At UC Davis, mTBI patients admitted to the hospital are administered a novel screener, the UCD-Cog, which is based on the speech pathology department’s experience with the Cognistat Cognitive Assessment and evaluates the patient on 16 aspects of cognition and behavior.  We present the UCD-Cog cognitive profile of hospitalized mTBI patients and associated functional outcomes at 6 months.

To describe the cognitive profile of acute, hospitalized mTBI patients, and associations with functional outcomes at 6 months post-injury.

345 TBI patients who were evaluated by the UC Davis Neurosurgery Department over a 1-year period met the inclusion criteria of age >= 18 years, Glasgow Coma Score (GCS) 13-15, and participation in inpatient UCD-Cog evaluation and 6-month outpatient follow-up.  Associations between UCD-Cog performance and 6-month Glasgow Outcome Scale-Extended (GOSE) scores were assessed by nonparametric Kruskal-Wallis Tests (KWT) with Bonferroni Correction.  We also evaluated for associations between age, GCS, gender, CT-Head abnormalities, mechanism-of-injury, and UCD-Cog performance.

UCD-Cog performance on 7 of 16 measures (orientation, attention, immediate-recall, delayed-recall, autobiographic memory, executive function, processing speed) were associated with significant differences in 6-month GOSE scores (χ2(7) = 35.1, p < 0.00001, n = 345). mTBI patients with impairments in more than 5 of these 7 measures reported a 2-point lower GOSE than those with zero impaired measures (4.2 vs 6.5, post-hoc Dunn’s Test, p.adj < 0.01). Only GCS and age showed significant differences with UCD-Cog performance (KWT, p.adj < 0.001).

UCD-Cog may assist with early identification of cognitive deficits associated with worse mTBI outcomes.  Patients with impairments on greater than 5 of 7 select UCD-Cog measures may be at risk for persistent post-concussive syndrome.

Wentao Li, MD (The Permanente Medical Group)
Dr. Li has nothing to disclose.
Matthew Nedjat-Haiem (UC Davis School of Medicine) Mr. NEDJAT-HAIEM has received personal compensation for serving as an employee of Aptose Biosciences.
Erin D. Bigler, PhD (Erin D. Bigler, Ph.D.) Dr. Bigler has received personal compensation in the range of $50,000-$99,999 for serving as an Expert Witness for Erin D. Bigler, Ph.D., Private Consulting Practice. Dr. Bigler has received publishing royalties from a publication relating to health care.
No disclosure on file
No disclosure on file
Ryan M. Martin, MD (UC Davis School of Medicine) Dr. Martin has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Spinelli, Donald, & Nott. Dr. Martin has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Demas Law Group.