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Abstract Details

Role Of Antimüllerian Hormone Levels and Neurofilament Light Chains In Family Planning In MS
Multiple Sclerosis
P1 - Poster Session 1 (8:00 AM-9:00 AM)
3-014

Serum NfL values are considered biomarkers for neuroaxonal injury. Their levels associate with relapse activity, disability scores, and treatment response in MS. On the other hand, AMH levels are a reliable marker of ovarian reserve and age at menopause. Interestingly, serum AMH levels do not change significantly throughout the menstrual cycle

To explore the utility of Neurofilament light chain (NfL) and Antimüllerian hormone (AMH) in family planning in multiple sclerosis (MS). 

A cross-sectional study was performed. We included naïve patients with MS, recruited at the time of diagnosis. Clinical and epidemiological data were analyzed. Serum NfL levels were measured with a sensitive single-molecule array (SIMOA) assay, and AMH levels were measured by ELISA. Descriptive and multivariate analyses were performed. Results are expressed by median and interquartile range 25%-75%.

We included 112 MS patients. Median age 35.25 years old (30.35-40.65). We divided the patients into two groups according to their AMH levels, using values that represented a median ovarian reserve. We found that age was significantly associated with AMH levels (P < 0.01. Median AMH values 0.2 ng/ml [0.1-0.5]).  We further divided our participants into two groups according to their NfL levels using a cut-off value of 10 pg/ml and found no statistical difference between groups (p: 0.3; median NfL: 7.5 pg/mL [5.5- 12.2]). Interestingly, when analyzing individual patients, we were able to identify those with an unexpectedly low AMH level, regardless of their age.


AMH levels can also be used as a biomarker of ovarian reserve in MS patients. Furthermore, our data suggest that AMH and NfL levels at diagnosis might help develop a personalized treatment strategy in patients of childbearing age and support informed decisions about whether or not to delay childbearing.

Authors/Disclosures
Juan Pablo Cuello (Hospital General Universitario Gregorio Maran)
PRESENTER
Juan Pablo Cuello has nothing to disclose.
Ariana Meldaña Rivera Ariana Meldaña Rivera has nothing to disclose.
Jose Manuel Garcia Dominguez (Hospital General Universitario Gregorio Marañón) Jose Manuel Garcia Dominguez has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi Genzyme. Jose Manuel Garcia Dominguez has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Jose Manuel Garcia Dominguez has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Jose Manuel Garcia Dominguez has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Merck. Jose Manuel Garcia Dominguez has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Almirall. Jose Manuel Garcia Dominguez has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Abbvie. Jose Manuel Garcia Dominguez has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for merck. Jose Manuel Garcia Dominguez has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Jose Manuel Garcia Dominguez has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi Genzyme. Jose Manuel Garcia Dominguez has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. Jose Manuel Garcia Dominguez has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Jose Manuel Garcia Dominguez has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Teva. Jose Manuel Garcia Dominguez has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Almirall.
Alexander Rodero Romero, PhD Mr. Rodero Romero has nothing to disclose.
Haydee Goicochea Briceño haydee goicochea briceño has received personal compensation in the range of $0-$499 for serving as a Consultant for Merck. haydee goicochea briceño has received personal compensation in the range of $0-$499 for serving as a Consultant for Roche. haydee goicochea briceño has received personal compensation in the range of $0-$499 for serving as a Consultant for Almirrall. haydee goicochea briceño has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Bayer. haydee goicochea briceño has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Novartis. haydee goicochea briceño has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Teva. haydee goicochea briceño has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Merk. haydee goicochea briceño has received research support from IOMSN.
Elda María Maria Alba Suarez, PhD (Suárez) Mrs. Alba Suarez has nothing to disclose.
Enric Monreal Laguillo Enric Monreal Laguillo has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Enric Monreal Laguillo has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Enric Monreal Laguillo has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Enric Monreal Laguillo has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Merck. Enric Monreal Laguillo has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Bristol-Myers Squibb. Enric Monreal Laguillo has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. Enric Monreal Laguillo has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi. Enric Monreal Laguillo has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Enric Monreal Laguillo has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck. Enric Monreal Laguillo has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Janssen. Enric Monreal Laguillo has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bristol-Myers Squibb.
Susana Sainz de la Maza Susana Sainz de la Maza has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Almirall, Biogen, Merck, Novartis, Roche and Sanofi-Genzyme.
Lucienne Costa Costa-Frossard Franca, Sr., PhD (Hospital Universitario Ramón y Cajal) Dr. Franca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Almirall. Dr. Franca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. Dr. Franca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer. Dr. Franca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biopas. Dr. Franca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bristoll-Mayer. Dr. Franca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Ipsen. Dr. Franca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck. Dr. Franca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Dr. Franca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi. Dr. Franca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Teva. Dr. Franca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche.
Juan De-León Luis juan de-leon ruiz has nothing to disclose.
Carmen Martinez Asensio, MD Mrs. Martinez Asensio has nothing to disclose.
Lourdes Fatima Yllana Pérez Mrs. Yllana Pérez has nothing to disclose.
Yolanda Higueras Yolanda Higueras has nothing to disclose.
Maria Luisa Martinez Gines, MD Dr. Martinez Gines has nothing to disclose.
Luisa M. Villar (Hospital Ramon Y Cajal) Luisa M. Villar has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Luisa M. Villar has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Bristol-Myers Squibb. Luisa M. Villar has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi. Luisa M. Villar has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck. Luisa M. Villar has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Luisa M. Villar has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Luisa M. Villar has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bristol-Myers Squibb. The institution of Luisa M. Villar has received research support from European Union. The institution of Luisa M. Villar has received research support from Instituto de Salud Carlos III (Spanish Goverment).