Log In

Forgot Password?

OR

Not a member? Continue as a nonmember.

Become a Member

By becoming a member of the AAN, you can receive exclusive information to help you at every stage of your career. Benefits include:

Join Now See All Benefits

Loading... please wait

Abstract Details

Novel Pathways Correlating with MS-Related Tremor, A Case-Control Study
Multiple Sclerosis
P10 - Poster Session 10 (8:00 AM-9:00 AM)
3-001

MS-related tremor is characteristically resistant to treatment, affecting 25% and 58% of the patients with MS.

Identifying the white matter fiber pathways responsible for tremor in Multiple Sclerosis (MS).

Patients with MS-related tremor (n=36) had 3.0 T MRI scans with T1-weighted, FLAIR, and diffusion-weighted (DWI) sequences. Subjects were gender and age-matched with a control MS group (n = 36) without tremor.

Using regional brain diffusivity measures obtained from MRICloud and diffusion connectometry findings from DSI Studio, we identified 53 tracts-of-interest associated with MS-related tremor.

Tractography of the identified tracts was performed in DSI Studio. The diffusion data were reconstructed using generalized q-sampling. A supervised atlas-based tractography method was used to segment the pathways using tract-specific parameters set based on neuroanatomical topology and standardized across subjects.

We obtained the partial spearman correlation coefficients (rs) for tremor severity with mean tract diffusivity measures adjusting for possible confounders.

Of the 53 tracts, 5 showed negative correlation between mean tract fractional anisotropy (FA) and tremor severity: the left medial lemniscus (rs = -0.55, p = < .001), the forceps minor of the corpus callusom (rs = -0.45, p = 0.009), the right anterior corticostriatal tract (rs = -0.413, p = 0.017), the forceps major of the corpus callusom (rs = -0.376, p = 0.031), and the fornix (rs = -0.367, p = 0.035). Of these tracts 3 had radial diffusivity (RD) values significantly correlating with tremor severity, namely the left medial lemniscus (rs = 0.429, p = 0.013), the right anterior corticostriatal tract (rs = 0.379, p = 0.029), and the forceps minor of corpus callosum (rs = 0.369, p = 0.034).

Using two independent techniques, we identified pathways associated with MS-related tremor. For the first time, we show that commissural, medial lemniscus, and striatal tracts correlate with tremor severity.

Authors/Disclosures
Ahmed Amr Mohmed Bayoumi (McGovern Medical School)
PRESENTER
Mr. Bayoumi has nothing to disclose.
Khader Hasan Khader Hasan has nothing to disclose.
Jorge Eduardo Patino Murillas, MD (The University of Texas Health Science Center at Houston McGovern Medical School) Dr. Patino Murillas has nothing to disclose.
John A. Lincoln, MD, PhD (McGovern Medical School, UTHealth) The institution of Dr. Lincoln has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi-Genzyme. Dr. Lincoln has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Biogen. The institution of Dr. Lincoln has received research support from Deaprtment of Defense. The institution of Dr. Lincoln has received research support from National Institutes of Health. The institution of Dr. Lincoln has received research support from EMD-Serono. Dr. Lincoln has received intellectual property interests from a discovery or technology relating to health care.