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Abstract Details

Does Elevated Inflammatory Markers Predict Functional Outcomes in Hospitalized Patients with COVID-19 and Acute stroke?
Cerebrovascular Disease and Interventional Neurology
P14 - Poster Session 14 (11:45 AM-12:45 PM)
The association of acute Coronavirus disease 2019 (COVID-19) with both arterial and venous thromboembolic events is well-established. One of the several proposed mechanisms is excessive inflammatory response. We aim to assess if higher inflammatory markers are associated with worse functional outcomes 
To determine if elevated inflammatory markers are associated with worse functional outcomes in SARS-CoV-2 positive patients presenting with acute cerebrovascular events. 
Medical records of adult patients admitted to our institution between 3/2020 and 8/2021 with positive SARS-COV-2 and acute cerebrovascular events were reviewed (n=29). Demographics, neuroradiological and pertinent lab findings were collected. Functional outcomes were assessed using binarized mRS scores (worse 4-6 vs better 0-3) ascertained on discharge day.  A series of logistic regression models were utilized to assess the association of inflammatory markers with stroke outcomes. Variables assessed were; [admission day heart rate, temperature and white blood cell count], binarized maximum procalcitonin ( > 0.1 ng/mL vs </= 0.1 ng/mL) and maximum ferritin level. All analyses were conducted using SAS software. 
Among 29 patients (mean age 63.6 +/- 13.4 years, 65.5% males), tested parameters of inflammation were not shown to be significantly associated with stroke outcomes in an adjusted logistic regression model. When assessing stroke outcome via binarized modified Rankin stroke scale, binarized maximum procalcitonin level showed 1.95 times the odds of a poor outcome (OR: 1.95, 95% CI: 0.05, 84.3, p-value: 0.73). Additionally, temperature on admission showed 1.59 times the odds of a poor outcome (OR: 1.59, 95% CI: 0.42, 6.07, p-value: 0.17). 
Among patients with acute cerebrovascular events associated with positive SARS-COV-2 result, no significant associations of worse functional outcomes in those with elevated inflammatory markers were observed. A trend of higher mRS scores on discharge in those with elevated procalcitonin and those with fever on admission was noted. Further research is needed to confirm these findings  
Omar Elsekaily, MBBS (LSU shreveport)
Dr. Elsekaily has nothing to disclose.
Junaid Ansari, MD (LSU Health Shreveport) Dr. Ansari has nothing to disclose.
Mohammad Abdurrehman Sheikh, MBBS (LSU Health Shreveport) Dr. Sheikh has nothing to disclose.
Muhammad Ayub, MD (Louisiana State University, Shreveport) Dr. Ayub has nothing to disclose.
Rachel Elizabeth Triay, MD (Case Western / University Hospitals Cleveland) Dr. Triay has nothing to disclose.
Alexis Angelette, MD (New York Presbyterian) Miss Angelette has nothing to disclose.
Alexandra Gaudet Ms. Gaudet has nothing to disclose.
Roger E. Kelley, Jr., MD, FAAN (LSU Health Sciences Center) Dr. Kelley has nothing to disclose.