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Abstract Details

Medial Temporal Tau Predicts Memory Decline in Cognitively Unimpaired Elderly
Aging, Dementia, Cognitive, and Behavioral Neurology
P5 - Poster Session 5 (11:45 AM-12:45 PM)

Alzheimer’s disease (AD) can be detected in living people using in vivo biomarkers of amyloid-β (Aβ) and tau, even in the absence of cognitive impairment during the preclinical phase. [18F]-MK-6420 is a high affinity positron emission tomography (PET) tracer that quantifies tau neurofibrillary tangles, but its ability to predict cognitive changes associated with early AD symptoms, such as memory decline, is unclear.

Here, we assess the prognostic accuracy of baseline [18F]-MK-6420 tau PET for predicting longitudinal memory decline in asymptomatic elderly individuals.

In a longitudinal observational study, we evaluated a cohort of cognitively normal elderly participants  from the Translational Biomarkers in Aging and Dementia (TRIAD) study (October 2017-July 2020, follow-up period of 12 months). All participants underwent tau PET with [18F]-MK-6420 and Aβ PET with [18F]-AZD-4694.

There were 111 eligible participants who were chosen based on the availability of Aβ PET, tau PET, magnetic resonance imaging (MRI), and APOEε4 genotyping. Among these participants, the mean (SD) age was 70.1 (8.6) years; 20 (18%) were tau PET positive and 71 of 111 (63.9%) were women. A significant association between baseline Braak I-II [18F]-MK-6240 SUVR positivity and change in composite memory score was observed at the 12 month follow-up, after correcting for age, sex, and years of education (Logical Memory and RAVLT, standardized beta = -0.52 (-0.82-0.21), p < 0.001, for dichotomized tau PET and -1.22 (-1.84-(-0.61)), p < 0.0001, for continuous tau PET). Moderate cognitive decline was observed for A+T+ over the follow-up period, whereas no significant change was observed for A-T+, A+T- and A-T-, though it should be noted that the A-T+ group was small. Our results indicate that baseline tau neurofibrillary tangle pathology is associated with longitudinal changes in memory function.

[18F]-MK-6420 PET is a promising tool for predicting memory decline in older adults without cognitive impairment at baseline.

Angela T.H. Kwan, MSc
Miss Kwan has nothing to disclose.
Saman Arfaie, Other Mr. Arfaie has nothing to disclose.
William Joseph Therriault (McGill Center for Studies in Aging) Mr. Therriault has nothing to disclose.
Zahra Azizi, MD (Stanford University) Dr. Azizi has nothing to disclose.
Firoza Zubeida Lussier, Other (McGill University) Miss Lussier has nothing to disclose.
Cecile Tissot (McGill University) Mrs. Tissot has nothing to disclose.
Mira Chamoun, PhD (McGill) Dr. Chamoun has nothing to disclose.
Gleb Bezgin Dr. Bezgin has nothing to disclose.
Stijn Servaes Dr. Servaes has nothing to disclose.
Jenna Stevenson, Other (McGill University) Miss Stevenson has nothing to disclose.
Nesrine Rahmouni, Other (McGill Research Centre for Studies in Aging) Ms. Rahmouni has nothing to disclose.
Vanessa Pallen, Other (McGill University Research Center for Studies in Aging) Miss Pallen has nothing to disclose.
Pedro Rosa Neto, MD, PhD (McGIll University) The institution of Dr. Rosa Neto has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Novo Nordisk.