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Abstract Details

Association of Life’s Simple 7 with Brain Imaging Outcomes Among Hispanics/Latinos. Results from the Study of Latinos-Investigation of Neurocognitive Aging-MRI (SOL-INCA-MRI) Ancillary Study
Aging, Dementia, Cognitive, and Behavioral Neurology
P14 - Poster Session 14 (11:45 AM-12:45 PM)
7-001
The Life’s Simple 7 (LS7) score includes not smoking, adequate weight and physical activity, a healthy dietary pattern, and controlled blood pressure, total cholesterol, and fasting serum glucose. Higher LS7 scores are associated with better cognitive function.
Investigate the associations of LS7 with brain volumes, measured by MRI, in Hispanic/Latino adults. 

Participants (n=2109; mean age 67.7 years) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) underwent 3T brain MR imaging. We determined total brain, total and regional grey matter (frontal, temporal, parietal, and occipital), total white matter, total CSF, lateral ventricle (LV), and white matter hyperintensity (WMH) volumes. Volumes were residualized for total cranial volume. WMH and LV volumes were Ln-transformed. LS7 (range: 0-14) was categorized into quartiles (Q) with higher scores representing better cardiovascular health. MRI outcomes across LS7 quartiles were investigated using linear regression analysis weighted and accounted for complex survey design and adjusted for baseline characteristics. In an exploratory analysis, we also explored if LS7 modified brain volume-age associations.

 The mean±SD LS7 score was 8.32±2.21. In the fully adjusted model, individuals in Q4 (versus Q1) had larger total brain (β=0.25, 95% CI=0.04, 0.46), total white matter (β=0.22, 95% CI=0.06, 0.37), and total grey (β=0.21, 95% CI=0.07, 0.36) volumes and smaller total CSF (β=-0.28, 95% CI=-0.44, -0.12) and WMH (β=-0.27, 95% CI=-0.45, -0.09) volumes. Test for interaction showed less pronounced age-related MRI changes among individuals in Q4 (versus Q1) for total brain (β=0.004, 95% CI=0.0003, 0.007), total white (β=0.004, 95% CI=0.001, 0 .006), total grey (β=0.003, 95% CI=0.001, 0.005), total CSF (β=-0.004, 95% CI=-0.007, -0.002), LV (β=-0.004, 95% CI=-0.008, 0.001), and WMH (β=-0.004, 95% CI=-0.007, -0.001) volumes. 

The highest LS7 quartile was associated with better brain MR imaging outcomes and lower cross-sectional age-related volumetric changes among Hispanic/Latino adults.  

Authors/Disclosures
Fernando D. Testai, MD, PhD, FAAN (University of Illinois at Chicago)
PRESENTER
Dr. Testai has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. Dr. Testai has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Swanson Martin & Bell, LLP. Dr. Testai has received publishing royalties from a publication relating to health care.
Gabriela Trifan, MD (UIC, Department of Neurology) Dr. Trifan has nothing to disclose.
Ariana Stickel Ariana Stickel has nothing to disclose.
Jianwen Cai (University of North Carolina at Chapel Hill) The institution of Jianwen Cai has received research support from NIH.
Martha Daviglus The institution of Martha Daviglus has received research support from NIH.
Mayra L. Estrella, PhD Prof. Estrella has nothing to disclose.
Olga Garcia-Bedoya, MD (University of Illinois Chicago) Dr. Garcia-Bedoya has nothing to disclose.
Linda C Gallo The institution of Linda C Gallo, 8429 has received research support from NIH.
Carmen Isasi, MD,PhD Dr. Isasi has nothing to disclose.
Robert Kaplan No disclosure on file
Melissa Lamar, PhD (Rush Alzheimer's Disease Center) The institution of Dr. Lamar has received research support from National Institute on Aging. Dr. Lamar has received publishing royalties from a publication relating to health care.
Gregory Anthony Talavera, MD (San Diego State University) The institution of Dr. Talavera has received research support from NIH/NHLBI.
Wassim Tarraf Wassim Tarraf has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Alzheimer's Association - Alzheimer and Dementia Journal. The institution of Wassim Tarraf has received research support from National Institute on Aging.
Donglin Zeng, PhD (University of North Carolina) Dr. Zeng has nothing to disclose.
Hector M. Gonzalez No disclosure on file
Charles S. DeCarli, MD, FAAN (UC Davis Health - Dept of NeurologyAlzheimer's Disease Research Center) Dr. DeCarli has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. The institution of Dr. DeCarli has received research support from NIH.