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Abstract Details

Pulmonary Embolism in Patients with Traumatic Brain Injury in the United States During 2016-2020
Neuro Trauma and Critical Care
P9 - Poster Session 9 (5:30 PM-6:30 PM)
Deep venous thrombosis (DVT), often prodromal for pulmonary embolism (PE) causes significant morbidity and mortality. Understanding factors contributing to PE in TBI patients can help better control the outcomes in this population. 
We aim to find the incidence of PE in traumatic brain injury (TBI) and the impact of comorbidities on the development of PE.
This is a retrospective study of inpatient subjects from 2016-2020 with TBI collected from the Healthcare Cost and Utilization Project (HCUP). The cohort was dichotomized to the presence or absence of PE, and were evaluated for demographics, types of TBI, and comorbidities. Regression statistical analysis was conducted to find the odds of developing PE in TBI. 

During five years study period, we studied 206,708 TBI cases, of which 1324 developed PE (0.65%) and 3584 developed DVT (1.8%). The cohort was composed mostly of white (71.5%), and males (60%) with a mean age of 64.8 y/o. Most types of TBIs were subdural hematoma (49.3%). The patients who developed PE were younger (61.1 vs. 64.9, p<0.001), male (66.9%, p<0.001), had longer hospital stays (18.4 vs 6.9 d, p<0.001), and had significantly higher mortality (13,7% vs. 8.1%, p<0.001).

In Multivariate analysis, having DVT (OR.9.85, 95% CI [5.5-17.6], p<0.001), COPD (OR, 1.33, 95% CI[ 1.08-1.64], p=0.009) and Renal disease (OR 1.3 , 95%CI[ 1.3-1.5], p<0.001) and black race (OR1.27, 95%CI[ 1.07-1.5], p=0.006) had the highest impact on developing PE. Of the different types of TBI, Epidural hemorrhage had the most effect on developing PE (OR. 1.43, 95%CI [ 1.01-2.02],p=0.04). 

Our data shows the incidence of PE and DVT in TBI is low; however, it's lethal with a high LOS. The incidence of PE is higher in Blacks and in those with DVT, COPD, and Renal failure. Among different types of TBI, Epidural hematoma has the highest association with the development of PE. 

Carlos Garcia Rodriguez, MD
Dr. Garcia Rodriguez has nothing to disclose.
Maggie Moran, MD (UTHSCSA) Dr. Moran has nothing to disclose.
David Momtaz, Other Mr. Momtaz has nothing to disclose.
Paola *Use 333412 Martinez, MD No disclosure on file
Kevin Chen No disclosure on file
Ali Seifi Ali Seifi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Chiesi. Ali Seifi has received intellectual property interests from a discovery or technology relating to health care.