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Abstract Details

MxA Protein Expression and Histological Characteristics on Muscle Biopsy in Myositis
Neuromuscular and Clinical Neurophysiology (EMG)
P9 - Poster Session 9 (5:30 PM-6:30 PM)
10-001
The myxovirus resistance protein A (MxA) is one of the most highly induced protein by type I interferons. The current international neuromuscular workshop recognizes MxA reactivity on myofibers as a definitive marker for dermatomyositis, with 98-100% specificity on muscle biopsies. However, many type I interferon driven inflammatory myositis have not been tested in previous studies.

To evaluate both myofiber and capillary MxA expression in a wide range of potentially type 1 interferon driven myositis.

We evaluated both myofiber and capillary MxA expression in a wide range of potentially type 1 interferon driven myositis, including lupus myositis, HIV myositis, Sjogren’s disease associated myositis, systemic sclerosis associated myositis and antisynthetase syndrome associated myositis. Dermatomyositis and immune mediated necrotizing myopathy served as positive and negative control, respectively. We also cross compared the presence of endothelial tubuloreticular inclusions (TRI), another type 1 interferon activation marker, with MxA expressions. 
Myofiber MxA expression was present in 78.9% (15/19) of active lupus myositis but was uncommon in active myositis associated with HIV (1/18), Sjogren’s disease (1/12), systemic sclerosis (2/14), and antisynthetase syndrome (2/11).   Capillary MxA expression was much more prevalent and less specific, present in lupus (18/19), HIV (8/18), Sjogren’s disease (9/12), systemic sclerosis (11/14), and antisynthetase syndrome (9/11). There was a positive correlation between myofiber MxA expression and presence of endothelial tubuloreticular inclusions. Histologically, lupus myositis was characterized by a “pan-fascicular” necrotizing myopathy pattern. 

MxA myofiber expression is not a specific marker for dermatomyositis. Nevertheless, MxA is still a highly useful tool in muscle biopsy whose myofiber expression is strongly suggestive of either dermatomyositis or lupus myositis. The “pan-fascicular” necrotizing myopathy pattern in lupus myositis may serve as a useful histological feature to differentiate from the “perifascicular” injury pattern in dermatomyositis.

Authors/Disclosures
Jaya Raghav Trivedi, MD, FAAN (UT Southwestern Medical Center)
PRESENTER
Dr. Trivedi has nothing to disclose.
Changhong Xing, PhD,MD Dr. Xing has nothing to disclose.
Nicole Bitencourt No disclosure on file
Chunyu Cai Chunyu Cai has nothing to disclose.