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Abstract Details

Handheld Muscle Ultrasound as a Tool to Assess Muscle Strength and Function in Sporadic Inclusion Body Myositis
Neuromuscular and Clinical Neurophysiology (EMG)
P9 - Poster Session 9 (5:30 PM-6:30 PM)
10-002

sIBM can be difficult to diagnose from other causes of painless weakness.  One of the hallmarks of the disease is weakness of the deep finger flexors that may be missed by those who do not routinely see sIBM.  In particular, comparison of echogenicity between the flexor digitorum profundus (FDP) and flexor carpi ulnaris (FCU) muscles with relative FCU sparing has been shown to provide diagnostic specificity for sIBM from other neuromuscular diseases.

Determine the feasibility and utility of handheld neuromuscular ultrasound in the assessment of patients with sporadic inclusion body myositis (sIBM).

15 patients with sIBM (mean age: 69.9 ± 7.2 years; 60% male; 11.2 ± 7.0 years since symptom onset; 80% with confirmed histopathological diagnosis) underwent ultrasound assessment with the handheld Butterfly iQ+ ultrasound. Pinch, and grip strength were measured quantitatively with dynamometry. Disability and physical function were measured using patient-reported outcomes.  The semi-quantitative Heckmatt grading scale was used to measure muscle echogenicity.

Heckmatt echogenicity for the FDP and FCU was found to moderately correlate with ipsilateral hand grip strength (FCU: rho = -0.68, p = 0.007; FDP: rho = -0.56, p = 0.036) as well as pinch strength. Increasing echogenicity of the FDP and FCU combined in the dominant forearm was also moderately correlated with decreasing hand function as reported by the patient-reported IBM Upper Extremity Function scale (rho = -0.64, p = 0.019). 67% of patients had increased FDP echogenicity compared to FCU.

Increased muscle echogenicity on the Heckmatt scale, reflecting fibrosis and fatty infiltration, is associated with decreasing muscular strength and patient reported outcomes in patients with sIBM. The Butterfly iQ+ is a low-cost, safe, and non-invasive tool for assessing muscle involvement in sIBM.

Authors/Disclosures
Aliya Shabbir
PRESENTER
Ms. Shabbir has nothing to disclose.
Carolyn Black, MD, PhD (St. Luke's Rehabilitation) Dr. Black has nothing to disclose.
Leo Hong-Li Wang, MD, PhD, FAAN (University of Washington) Dr. Wang has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for AskBio. Dr. Wang has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Fulcrum Therapeutics. Dr. Wang has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Dr. Wang has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Mitsubishi Tanabe. Dr. Wang has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Argenx. Dr. Wang has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Avidity. Dr. Wang has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Scholar Rock. The institution of Dr. Wang has received research support from National Institute of Health. Dr. Wang has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant with US Government.
Haibi Cai, MD Dr. Cai has nothing to disclose.