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Abstract Details

Diversity, Equity, and Inclusion in Local Clinical Trials
Health Care Disparities
P5 - Poster Session 5 (11:45 AM-12:45 PM)
Clinical trials tend to disproportionately enroll white, male subjects calling into question the generalizability of these studies. The University of Minnesota Stroke Program has helped pioneer telemedicine and remote research practices in stroke clinical trials in collaboration with NIH Stroke Trials Network. This infrastructure supports 24-7 study recruitment that is directly integrated into clinical practice and informs an internal culture of approaching all eligible patients for participation in clinical trials without internal selection bias.
To promote diversity, equity, and inclusion (DEI) in clinical trials through remote research practices

We retrospectively reviewed all enrollments in three Phase-III acute stroke clinical trials (NCT03735979, NCT03785678, NCT02864953) enrolled at our tertiary stroke center (Fairview Southdale Hospital) from June 30, 2019 - April 30, 2022. We compared demographics (age, gender, race, ethnicity, and primary language [English: yes/no]) of cohort enrolled in clinical trials versus demographics of general stroke patient population utilizing chi-squared testing and descriptive statistics.

Sixty-eight patients were enrolled in acute stroke trials (34 in MOST,30 in TIMELESS, 4 in CHARM) with a median age of 71 (IQR 20.25) at Fairview Southdale Hospital.

Race     Enrollment       Patient Population

White   86.76% (59)       86.7% (2282)


American 5.88% (4)        5.7% (149)

Asian       4.41% (3)          3% (79)

Others      1.47% (1)        4.6% (121)

Language      Enrollment     Patient population

English          94.1% (64)       96.6% (2526)

Somali             2.94% (2)       0.535% (14)

Vietnamese       1.47% (1)        0.46% (12)

Others                1.47% (1).      2.5% (63)

Ethnicity        Enrollment      Patient Population

Non-Hispanic  94.1% (64)     79.51% (2079)

Hispanic or Latino 1.47% (1)   1.68% (44)

Others/Unknown 4.41% (3)    18.81% (492)

Gender       Enrollment       Patient Population

Male             51% (35)           47% (1496)

Female           49% (33)         53% (1688)

We found no notable differences in gender, race, and ethnicity between our clinical trial and non-clinical trial stroke cohorts. Remote research practices eliminates inherent selection bias in clinical research teams and may reduce disparities in clinical trial representation.
Saketh Annam, MBBS (West Virginia University)
Dr. Annam has nothing to disclose.
Solmaz Ramezani Hashtjin, MD (University of Minnesota) Dr. Ramezani Hashtjin has nothing to disclose.
Shayan Khan, Other (university of minnesota) Dr. Khan has nothing to disclose.
Abbey Staugaitis Abbey Staugaitis has nothing to disclose.
Christopher Streib, MD (Department of Neurology) Dr. Streib has nothing to disclose.