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Abstract Details

The Analysis of 607 Volunteers Shows a Reduction of Workability in Individuals With LONG-COVID Syndrome Associated With Neuropsychiatric Symptoms
Infectious Disease
P5 - Poster Session 5 (11:45 AM-12:45 PM)
13-004
Few studies evaluated the impact of neuropsychiatric symptoms (fatigue, depression, anxiety and excessive sleepiness) on workability in a homogeneous group of workers.
To investigate symptoms associated with reducing of workability in individuals with LONG-COVID syndrome.
We evaluated 607 bank workers (mean age 42 years, 54% woman) after 200 days (on average) from confirmation of diagnosis of COVID19 (17% hospitalized and 83% non-hospitalized). Volunteers answered online forms including the “Chalder Fatigue Scale (CFQ)”, “Epworth Sleepiness Scale (ESS)”, “Hospital Anxiety and Depression scale (HADS)” and “Work Ability Index (WAI)”. We used SPSS22 for statistical evaluation with Chi-Square tests for analyses of proportions.

Approximately 85% completed higher education, and most (74.6%) worked in contact with the public. Overall, we identified 37.5% with normal WAI and 62.5% with reduced WAI in a group of 429 volunteers who answered the WAI questionnaire. Volunteers self-reported several symptoms, including fatigue (37%), anxiety (36%), cognitive dysfunction (29%) and depression (17%). Almost 20% were asymptomatic at the interview. However, the quantification of symptoms with formal questionnaires revealed excessive somnolence in 45%, fatigue in 79%, anxiety in 61% and symptoms of depression 66%. The comparisons of presence of these symptoms between groups with REDUCED-WAI and NORMAL-WAI revealed excessive sleepiness (25% versus 56% respectively; p<0.001), fatigue (93.2% versus 54% respectively; p<0.001), symptoms of depression (68.2% versus 18%; respectively, p<0.001) and anxiety (76.8% versus 30%, respectively p<0. 001).

In a longitudinal evaluation with 180 responders (average of 1 year after first interview), they self-reported fatigue (48%), anxiety (38%) and memory problems (52%).

Neuropsychiatric symptoms of LONG-COVID syndrome negatively affect work ability months after infection. These findings point to the urgence of specific and multidisciplinary treatments for patients to minimize the individual burden and the global economic loss.
Authors/Disclosures
Lucas Scárdua Silva, MD (University of Campinas)
PRESENTER
Dr. Silva has nothing to disclose.
Gabriel Monteiro Salvador, Other (State University of Campinas) Mr. Salvador has received research support from The Research Support Foundation of the State of São Paulo.
Mateus Nogueira Mateus Nogueira has nothing to disclose.
Italo Karmann Aventurato, MD Dr. Karmann Aventurato has received research support from Coordenadoria de Aperfeiçoamento de Pessoal de Ensino Superior (CAPES). Dr. Karmann Aventurato has received research support from Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP).
Fernando Cendes, MD, PhD, FAAN (Departamento de Neurologia; FCM; UNICAMP) Dr. Cendes has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for UCB Pharma. Dr. Cendes has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for UCB Biopharma. Dr. Cendes has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for United Medical – Brazil. Dr. Cendes has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Zodiac Pharma . Dr. Cendes has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Eurofarma – Brazil . Dr. Cendes has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Epilepsia. Dr. Cendes has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Frontiers in Neurology - Epilepsy. The institution of Dr. Cendes has received research support from São Paulo Research Foundation - FAPESP. The institution of Dr. Cendes has received research support from Conselho Nacional de Desenvolvimento Científico e Tecnológico - Brazil . The institution of Dr. Cendes has received research support from NIH.
Marcia Bandini No disclosure on file
Antonio De Cesare Del Nero, Other Mr. De Cesare Del Nero has received research support from Universidade Estadual de Campinas.
Clarissa L. Yasuda, MD, PhD (University of Campinas) Prof. Yasuda has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for LIBBS. Prof. Yasuda has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for ABBOTT. Prof. Yasuda has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for LIBBS.