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Abstract Details

Men with dementia are at increased risk of all-cause mortality following SARS-CoV-2 Vaccination
Infectious Disease
P5 - Poster Session 5 (11:45 AM-12:45 PM)
13-006
Amassing reports of death with close temporal association to SARS-CoV-2 vaccination warrants further investigation, especially after a nationwide mass vaccination campaign. With the release of uncontrolled data, vaccine fear and hesitancy fueled by the media prevents effective future implementation of vaccine rollout. As little information is known on this topic, we performed a prospective surveillance study on the risk factors of all-cause mortality post SARS-CoV-2 vaccination.
This study aimed to figure out the risk factors of all-cause mortality post SARS-CoV-2 vaccination.
Of 38,828,692 SARS-CoV-2 vaccine doses administered from February 2021 to March 2022 in the Gyeonggi Province, South Korea, a total of 687 cases of severe serious events and 353 cases of deaths were reported post SARS-CoV-2 vaccination. We compared the demographic characteristics between patients who were deceased, and patients who were reported to have suffered severe serious events but survived. Additionally, survival analysis was performed to assess the contributing risk for post-vaccination mortality.
Patients who died following SARS-CoV-2 vaccination were older, hospitalized, vaccinated in nursing facilities, received 3rd dose of vaccine, and had ischemic heart disease or dementia as comorbidity. In multivariate analysis, only male sex (crude IRR, 1.413; 95% CI, 1.026–1.947). and dementia (crude IRR, 1.644; 95% CI, 1.091–2.478) was associated with increased risk of death following vaccination, whereas hospitalization (crude IRR, 0.103; 95% CI, 0.076–0.139) was still significantly associated with decreased risk of mortality.
Men with dementia may be at increased risk of death following SARS-CoV-2 vaccination. If severe serious adverse event is suspected, prompt hospitalization may help reduce mortality. Government authorities should pay closer attention to these groups of patients to ensure safety following mass vaccination campaign.
Authors/Disclosures
Jin Myoung Seok, MD (Soonchunhyang University Hospital Cheonan)
PRESENTER
Jin Myoung Seok has nothing to disclose.
Jongmok Ha, MD Dr. Ha has nothing to disclose.
Suyeon Park, Other (Soonchunhyang University Seoul Hospital) Ms. Park has nothing to disclose.
Hyunwook Kang, MD Dr. Kang has nothing to disclose.
Taeeun Kyung, MD (Gyeonggi Provincial Government) Dr. KYUNG has nothing to disclose.
Namoh Kim, MD Mr. Kim has nothing to disclose.
Dong Kyu Kim, MD Dr. Kim has nothing to disclose.
Hyeonjoon Kim, MD Dr. KIM has nothing to disclose.
Kihoon Bae, MD Dr. Bae has nothing to disclose.
Min Cheol Song, MD Dr. Song has nothing to disclose.
Kwang June Lee, MD Dr. Lee has nothing to disclose.
Euiho Lee, MD Dr. Lee has nothing to disclose.
Beom Seuk Hwang, PhD (Chung-Ang University) Dr. Hwang has nothing to disclose.
Kunhee Park, MD,PhD Dr. Park has nothing to disclose.
Jinyoung Youn, MD,PhD (Samsung Medical Center) Prof. Youn has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Medtronic. Prof. Youn has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Boston Scientific. Prof. Youn has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Boston Scientific. Prof. Youn has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Myung-In Pharm. Prof. Youn has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Boston Scientific. Prof. Youn has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Eisai Co. Ltd. Prof. Youn has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for SK Chem.