Log In

Forgot Password?


Not a member? Continue as a nonmember.

Become a Member

By becoming a member of the AAN, you can receive exclusive information to help you at every stage of your career. Benefits include:

Join Now See All Benefits

Loading... please wait

Abstract Details

Assessing the Synergistic effect of Vitamin supplementation and Migraine preventative management in children and adolescents with chronic migraine- retrospective cohort analysis
P14 - Poster Session 14 (11:45 AM-12:45 PM)
Studies have shown evidence for mitochondrial energy depletion in migraine headaches1,2. Riboflavin and coenzyme q10 play a vital role in mitochondrial energy production and neuroprotective effects of vitamin D helps in migraine prevention.

To determine the synergistic effect of nutraceuticals and migraine preventatives for chronic migraine in children and adolescents.


This is a retrospective cohort analysis from an established electronic database (RedCap) from our tertiary care headache program. Participants were diagnosed with headache disorders based on international classification of headache disorders. As part of the initial visits, patients with chronic migraine were assessed for vitamin deficiencies and levels were quantified with standard reference ranges. Patients with vitamin deficiencies (25-OH vitamin D<30 ng/ml, vitamin B2<10nmol/L and coenzyme q10<0.7 microg/ml) were prescribed vitamin supplementation.

Out of 234 patients, 148 were diagnosed with chronic migraine. Mean age of patients at the time of diagnosis was 11.5±3.6 (range: 3-18). Out of 148, 103 received the vitamin labs and 78 were prescribed nutraceuticals based on the lab results. The mean total vitamin D level was 19.9±9.4 ng/ml, vitamin b2 level was 14.07±18.62 nmol/L and coenzyme q10 level was 0.9±2.09 microg/ml. Subset of patients; 39/78 returned for timely follow up (mean follow up duration 90 days). The average headache duration in this patient group improved from 15.03±21.19 to 5.3±9.3 hours (p<0.006), PedMIDAS disability score improved from 40.3±43.3 to 13.02±15.5 (p<0.001), headache frequency improved from 15.5±9.3 days to 8.7±7.7 days (p<0.001).
Deficiency of vitamin D, vitamin B2 and Coq10 may be common in pediatric and adolescent migraine. Determination of deficiency and consequent supplementation along with preventative management may result in clinical improvement. Further analysis in a bigger sample will be required to confirm this observation.
Peyton Isabella Crest (Rhodes College)
Ms. Crest has nothing to disclose.
Marley Lemons, Other (Le Bonheur Children's Hospital) Ms. Lemons has nothing to disclose.
Olivia Mccomb, NP Dr. Mccomb has nothing to disclose.
Brianna Freeman, RN Mrs. Freeman has nothing to disclose.
Jenny Schmidt, MD Dr. Schmidt has nothing to disclose.
Tracee Ridley Pryor, NP Dr. Ridley Pryor has nothing to disclose.
Ankita Ghosh, MD (Lebonheur Children's Hospital) Dr. Ghosh has nothing to disclose.