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Abstract Details

A comprehensive cognitive profile of patients with cervical dystonia
Aging, Dementia, Cognitive, and Behavioral Neurology
P5 - Poster Session 5 (11:45 AM-12:45 PM)
2-006

Cervical dystonia is the most prevalent phenotype of the adult onset idiopathic focal dystonias (AOIFD), a group of hyperkinetic disorders. Patients with AOIFD have been shown to have varying abnormalities in cognition. This non-motor feature is under-recognised and may influence QoL.

Studies into cognition in CD have been limited by inconsistent psychological assessment tools making generalisations difficult. We selected wide ranging neuropsychological tests to create a comprehensive cognitive profile.

To conduct a comprehensive analysis of cognition in cervical dystonia (CD).

13 adult patients (5 male, 8 female) with idiopathic focal CD completed an extensive neuropsychological battery. Participants were screened for presence of mood disorders (HADS). All patients were receiving 3 monthly botulinum toxin treatment and were not on any medications that could influence cognition.

Cognitive domains assessed: premorbid functioning, general intellectual functioning, language, information processing speed, attention, memory, executive function and social cognition using reliable and valid standardized neuropsychological assessments.

Mean age was 60-years. Mean HADS-A= 6 and mean HADS-D=5.

CD patients showed clear evidence of cognitive dysfunction compared to normative data. The most significant impairments were noted in social cognitive measures [emotional prosody to emotional face, FAB (mean Z score: -1.75); naming emotional prosody, FAB (mean Z score: -0.81)], executive function [SWMBE468, CANTAB (mean Z score: -0.73)] and, memory [LM2, WMS (mean Z score: -0.82)]. Moderate impairments were seen in information processing speed [WAIS coding (mean Z score: -0.51)], language [Boston Naming Test (mean Z score: -0.51)] and attention and working memory [RVPA, CANTAB (mean Z score: -0.61)].

 

Patients performed better than controls in another aspect of social cognition [conflicting emotional prosody, FAB (Z score: 1.67)].

 

There is mounting evidence of cognitive deficits in CD, implicating cognitive pathways in disease pathogenesis. This non-motor aspect may influence QoL and patient satisfaction. Early recognition and neuropsychological input could improve outcomes.

Authors/Disclosures
Shameer Rafee, MBBS (Department of Neurology)
PRESENTER
Dr. Rafee has nothing to disclose.
Madeleine Diepman Ms. Diepman has nothing to disclose.
Ruth Monaghan No disclosure on file
Derval McCormack, Other (Lancaster University) Miss McCormack has nothing to disclose.
Michael Hutchinson, MD (St Vincent's University Hospital) Dr. Hutchinson has nothing to disclose.
Fiadhnait O'Keeffe, PhD (St Vicnent's University Hospital Dublin) Dr. O'Keeffe has nothing to disclose.