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Abstract Details

Vitamin D and Post-stroke Depression: A Systematic Review and Meta-analysis
Cerebrovascular Disease and Interventional Neurology
P11 - Poster Session 11 (5:30 PM-6:30 PM)
5-013
Low vitamin D levels have often been associated with depression as well as worsen stroke outcomes. With post-stroke depression (PSD) being an important factor contributing to poor recovery and rehabilitation and thereby poor functional outcomes, this study was undertaken to explore the role of vitamin D deficiency in PSD and their correlation with stroke prognosis and outcomes.
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A systematic search of eligible studies from PubMed, MEDLINE, Cochrane CENTRAL, and Google Scholar were identified. Selected studies were those that met the inclusion criteria. Statistical analysis was conducted using Review Manager 5.4.1. A random-effects model was used to pool the data when heterogeneity was seen and so,results were reported in the standard mean differences within their corresponding 95% confidence interval.
 Our analysis showed statistically significant clinical depression in the Vitamin D deficient group on the BDIII (SMD= 6.90 [3.32, 10.48]; p= 0.0002) and PHQ-9 (SMD= 3.20 [1.84, 4.56]; p< 0.00001) scales. Of the seven studies, four showed significantly poorer prognosis in PSD patients with respect to NIHSS (SMD=1.54; [0.34, 2.74]; p< 0.0001) and MMSE (SMD= -2.53 [3.79, 1.27]; p< 0.0001).
This study shows a significant association between serum Vitamin D levels and PSD. Further studies are needed to explore causal relationships and the effect of vitamin supplementation on stroke prognosis and outcomes in relation to PSD
Authors/Disclosures
Nikhila Gandrakota
PRESENTER
No disclosure on file
Nithin C. Kurra, MBBS, MPH (University of Nebraska Medical Center) Dr. Kurra has nothing to disclose.
Kavya Sudireddy, MBBS (UMass Chan) Dr. Sudireddy has nothing to disclose.
MANJU RAMAKRISHNAN No disclosure on file
Naga Vijaya Lakshmi Boorle No disclosure on file
Dinesh V. Jillella, MD (Emory University School of Medicine / Grady Memorial Hospital) Dr. Jillella has nothing to disclose.