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Abstract Details

Depression in Older Adults with Epilepsy: A Cross-sectional Study Examining Prevalence, Risk Factors, and Socio-demographic Correlates in the Detroit Metropolitan Geriatric Population
Epilepsy/Clinical Neurophysiology (EEG)
P4 - Poster Session 4 (11:45 AM-12:45 PM)

Epilepsy in older adults poses a unique set of challenges associated with managing chronic seizures in the setting of disability, cognitive decline, and dependence. Depression is a common comorbidity of epilepsy, and may be under-diagnosed and undertreated 

To study the occurrence of depression in the geriatric epilepsy patient population and associated factors.

This cross-sectional study was conducted at the epilepsy outpatient clinic at Wayne State University. Subjects (age ≥ 55 years) with epilepsy were consented to participate in the study with IRB approval. Non-English speakers were excluded. Survey questions included patient demographics, seizure frequency, number of anti-seizure medications (ASM), the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) and Generalized Anxiety Disorder (GAD-7). Descriptive analysis to assess the occurrence of depression, and logistic regression analysis was conducted to find an association of depression with demographic factors while controlling anxiety.

A total of 127 unique epilepsy patients ≥ 55 years old were included, out of whom 49.2% were males, 84% identified as Black persons, 28% were on 2 or more ASMs. Positive depression results (NDDI-E ≥ 15) were present in 23.6% of the patients, 53.3% of whom were females. Average NDDI-E score was 10.7 (±4.4) On the NDDI-E score breakdown, most feelings of depression were related to every day struggling (86%), feeling guilty (76%), feeling frustrated (90%), whereas suicidal ideation was present in six (20%) of patients with depression. Logistic regression of age, gender, race, number of ASMs and seizure frequency did not show a significant relationship when controlled for anxiety.

Depression remains a significant comorbidity in older adults living with epilepsy. Findings of this study underscore the importance of screening for depression and suicidal ideation in this patient population.

Maryam J. Syed, MBBS (Wayne State University School of Medicine)
Dr. Syed has nothing to disclose.
Jeongyeon Hwang, MD (Detroit Medical Center) Dr. Hwang has nothing to disclose.
Deepti Zutshi, MD, FAAN (Wayne State University School of Medicine) Dr. Zutshi has nothing to disclose.
Rohit A. Marawar, MD, FAAN (Wayne State University - Detroit Medical Center) Dr. Marawar has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for SK Pharma. The institution of Dr. Marawar has received research support from Catalyst Pharma.