we included 63.8% females and 36.2% males. The age of the participants ranged from 17–26-year-old, with the majority between 20-23 years old. Additionally, 73.6% of the students were caffeine consumers, and 6.5% were smokers. In addition, 66% of medical students confirmed having two or more general headaches during the past three months. The prevalence of migraine was 27.25% in the whole study group. According to PHQ-4 scoring system, (36%) had a mild psychological distress (score: 3-5), (28.9%) reported severe distress (score: 9-12), while (24.7%) and (10.3%) reported moderate (score: 6-8) and none (score: 0-2) psychological distress, respectively. There was a significant association between the intensity of migraine without medications and the psychological status of the patient (P <0.05).