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Abstract Details

Prospective, Multicenter, International Registry of Deep Brain Stimulation for Dystonia: Sub-analysis of Cervical Dystonia Patients
Movement Disorders
P1 - Poster Session 1 (8:00 AM-9:00 AM)
3-018

In patients with cervical (focal) versus generalized dystonia, optimal DBS target sites (within pallidothalamic loop) are thought to diverge and be specific for particular connections. DBS devices equipped with capabilities such as directionality and Multiple Independent Current Control (MICC) may enable improved outcomes. 

The study objective is to assess/report real-world outcomes of patients with idiopathic, inherited, or acquired dystonia implanted with Multiple Independent Current Control (MICC)-based directional Deep Brain Stimulation (DBS) systems.  
This is a sub-analysis of patients with focal (cervical) dystonia only or cervical dystonia in context of segmental or generalized dystonia derived from a prospective, multicenter, international dystonia registry (NCT02686125). All patients receive an MICC-based, directional DBS system (Boston Scientific). Patients are followed up to 3-years (post-implant). The following assessments collected to evaluate dystonia symptoms include: Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS), quality-of-life, overall satisfaction, and adverse events.
A total of 50-patients (mean age 56.1-years, 62% females) with focal (cervical) dystonia only, and 95-patients (mean 43.6-years, 58% females) with cervical dystonia in context of segmental or generalized dystonia have been evaluated to date. In cervical only cohort, a 20-point improvement in overall TWSTRS score was noted at 6-months (n=35) and sustained up to 1-year (23.1-point improvement, n=30). In those with cervical dystonia in context of segmental or generalized dystonia, an 8.3- and 7.8-point improvement in overall TWSTRS scores was noted at 6- (n=62) and 12-months (n=48), respectively. Both evaluated groups reported the following level of improvement versus Baseline (Global-Impression-of-Change) at 12-months follow-up: 84% with cervical only and 82% of patients with cervical and other involved regions. 

This registry represents the first comprehensive, large-scale collection of real-world outcomes associated with dystonia patients implanted with directional, MICC-based DBS systems. Preliminary results demonstrate significant improvement in cervical dystonia patients (alone or in context of segmental or generalized dystonia) following DBS.

Authors/Disclosures
Alberto Albanese, MD (Universita Cattolica Sacro Cuore)
PRESENTER
Dr. Albanese has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Ipsen pharma. Dr. Albanese has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Merz pharms. Dr. Albanese has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Frontiers Publishing Group. Dr. Albanese has a non-compensated relationship as a President with International Association on Parkinsonism and Related Disorders that is relevant to AAN interests or activities.
No disclosure on file
Andrea Kuehn Andrea Kuehn has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Medtronic. Andrea Kuehn has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Boston Scientific.
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Yen F. Tai, MD (Hammersmith Hosp) The institution of Dr. Tai has received research support from Medical Research Council UK. The institution of Dr. Tai has received research support from Moulton Charitable Foundation.
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