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Abstract Details

Intake of B Vitamins and the Risk of Death Among Individuals with Parkinson’s Disease
Movement Disorders
P11 - Poster Session 11 (5:30 PM-6:30 PM)
3-018
Folate and vitamins B6 and B12 have been proposed as protective against the development of PD. Whether intake of these vitamins prior to or after disease diagnosis could reduce the risk of death among PD patients is unknown.
To prospectively examine the association between intake of B vitamins and the risk of death among individuals with Parkinson’s disease (PD).
The study population comprised 714 women from the Nurses’ Health Study and 801 men from the Health Professionals Follow-up Study who were newly diagnosed with PD during follow-up. Total intakes of folate, vitamin B6, and vitamin B12 were repeatedly assessed using a validated food frequency questionnaire. Mortality was ascertained via the National Death Index and state vital statistics records. For each vitamin, we fitted Cox regression models to estimate the hazard ratio (HR) and 95% confidence interval (CI) of death from all causes according to quartiles of cumulative average intakes.
We documented 973 deaths over 32 to 34 years of follow-up. A higher total intake of folate, vitamin B6, and vitamin B12 after PD diagnosis was not associated with a lower risk of death from all causes. In contrast, a lower risk of death was observed among those with a higher intake of these vitamins before PD diagnosis. The pooled hazard ratio comparing extreme quartiles of intake was 0.58 (95% CI:0.44-0.77; p-trend <0.001) for folate, 0.77 (95% CI:0.58-1.01; p-trend= 0.11) for B6, and 0.80 (95% CI: 0.64-1.01; p-trend=0.003) for B12. These associations appeared to be driven by intakes from supplemental sources.
The results of our study suggest that higher intakes of B vitamins before, but not after, disease diagnosis decrease the risk of death among individuals with PD.
Authors/Disclosures
Mario H. Flores, MD, PhD (Harvard T.H. Chan School of Public Health)
PRESENTER
Mr. Torres has nothing to disclose.
Xinyuan Zhang No disclosure on file
Chadwick W. Christine, MD, FAAN The institution of Dr. Christine has received research support from Neurocrine Biosciences. The institution of Dr. Christine has received research support from Brain Neurotherapy Bio, Inc. The institution of Dr. Christine has received research support from Michael J Fox Foundation for Parkinson's Research. The institution of Dr. Christine has received research support from Annovis Bio. The institution of Dr. Christine has received research support from Aspen Neurosciences.
Kjetil Bjornevik, MD, PhD (Harvard T.H. Chan School of Public Health) The institution of Dr. Bjornevik has received research support from Michael J. Fox Foundation. The institution of Dr. Bjornevik has received research support from National Multiple Sclerosis Society. The institution of Dr. Bjornevik has received research support from Department of Defense.
Albert Hung, MD, PhD (Massachusetts General Hospital) The institution of Dr. Hung has received research support from Parkinson's Foundation. The institution of Dr. Hung has received research support from Rho, Inc..
Michael Schwarzschild, MD, PhD (Massachusetts General Hospital) The institution of Dr. Schwarzschild has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bial Biotech (indirectly, as a service of the Parkinson Study Group service). The institution of Dr. Schwarzschild has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen (indirectly, as a service of the Parkinson Study Group service). The institution of Dr. Schwarzschild has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for UCB (indirectly, as a service of the Parkinson Study Group service). Dr. Schwarzschild has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eli Lilly. The institution of Dr. Schwarzschild has received research support from NIH. The institution of Dr. Schwarzschild has received research support from Parkinson's Foundation. The institution of Dr. Schwarzschild has received research support from Michael J Fox Foundation. The institution of Dr. Schwarzschild has received research support from Farmer Family Foundation. Dr. Schwarzschild has a non-compensated relationship as a Chair, Executive Committee with the Parkinson Study Group that is relevant to AAN interests or activities.
Alberto Ascherio, MD, PhD The institution of Dr. Ascherio has received research support from NIH and US Department of Defense .