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Abstract Details

Association of Severe Hyposmia and Frontal Lobe Dysfunction in Patients with Parkinson’s Disease
Movement Disorders
P4 - Poster Session 4 (11:45 AM-12:45 PM)
Pathological changes in frontal and temporal structures involving the olfactory process were confirmed in PD patients with hyposmia. FLD was associated with a deficit in odor identification among other neurological diseases such as frontotemporal dementia, amyotrophic lateral sclerosis, and cortico-basal syndrome. However, this relationship among PD patients remains unreported.
To determine the association between hyposmia and frontal lobe dysfunction (FLD) in patients with Parkinson’s disease (PD)
We retrospectively screened consecutive hospitalized patients with PD. We defined FLD as lower than 14 on the Frontal Assessment Battery. T & T olfactometer was used to evaluate for hyposmia, consisting of five different odors: floral smell like rose, sweet burning smell like pudding, sweaty smell like stuffy socks, fruity smell like canned peaches, and musty smell like feces. In this test, the odor-identification threshold is the primary indicator and severe hyposmia was defined as higher than four on a five-point scale. First, we aimed to reveal whether severe hyposmia could be associated with FLD. Second, we evaluated which specific odor items could be related to FLD.
We included 235 PD patients (125 [53 %] male, median age 69 years, and median Hoehn Yahr stage 2), and FLD was observed in 84 (36 %) patients. In multivariable logistic regression analysis, severe hyposmia (OR 2.860, 95% CI 1.103 – 7.417, p = 0.031) and lower MoCA-J (OR 0.666, 95% CI 0.578 – 0.766, p < 0.001) were associated with FLD. From the perspective of the odor item, severe hyposmia for fruity smell like canned peaches was associated with FLD (OR 3.752, 95% CI 1.370 – 10.276, p = 0.010).

Severe hyposmia was associated with FLD in patients with PD. Particularly, hyposmia for fruity smell like canned peaches might be a sensitive indicator for FLD.

Motohiro Okumura, MD (National Center of Neurology and Psychiatry)
Dr. Okumura has nothing to disclose.
Youhei Mukai, MD (University of Tokushima) Dr. Mukai has nothing to disclose.
No disclosure on file
Yuji Takahashi, MD, PhD (National Center of Neurology and Psychiatry) The institution of Dr. Takahashi has received research support from Nihon Medi-Physics Co. Limit.. The institution of Dr. Takahashi has received research support from Takeda Pharmaceutical Company Limited.