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Abstract Details

Clustered Difference of Gut Microbiome in Helicobacter Pylori Negative and Positive Group Effect on Clinical Motor Symptoms in PD (Helicobacter Pylori-Stool Microbiome or HP-SM Trial)
Movement Disorders
P9 - Poster Session 9 (8:00 AM-9:00 AM)
3-018
Previous studies have shown that Helicobacter pylori eradication therapy may improve motor function in Parkinson’s disease (PD). Still, there is an underrepresented implication between H. pylori eradication and gut microbiome alterations.
This study aims to evaluate the clinical motor outcomes in PD patients with H. pylori-negative compared to positive groups after H. pylori eradication associated with gut microbiome patterns.

This pilot prospective open-labeled, randomized, controlled trial was operated in patients with Parkinson’s disease to compare gut microbiome in negative and positive H. pylori infection. Successful eradication was defined as negative stool H. Pylori antigen. Gut microbiota was evaluated by 16S rDNA gene sequencing and subsequent bioinformatic analysis in both groups. MDS-UDPRS III-IV score, Levodopa equivalent daily dose and H&Y stage were assessed at week 8, 16, and 36. The GI function was quantified by using GIDS-PD. The primary outcome was the baseline-to-week 8 change in ON medication MDS-UPDRS motor scores. The diversity of gut microbiota was also interpreted in each group. 

We compared the fecal microbiome of five PD patients with H. pylori-positive and five PD patients with H. pylori-negative as control subjects before and after H. pylori eradication therapy. Regarding H. pylori eradication, there was significant reduction in MDS-UPDRS-III scores after treatment (p < 0.029). According to microbial diversity in fecal specimen, the analysis demonstrated that both H. pylori-negative and H. pylori-positive specimens are clustered in each group.

The clustered difference of gut microbiome in H. pylori negative and positive group showed the effect on clinical motor symptoms in PD. 

Authors/Disclosures
Wannisa Wongpipathpong, MD (Chakri Naruebodindra Medical Institue, Ramathibodi Hospital, Mahidol university)
PRESENTER
Miss Wongpipathpong has nothing to disclose.
No disclosure on file
No disclosure on file
No disclosure on file