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Abstract Details

The Relationship Between Clinical Hand Dexterity and Diffusion Tensor Imaging Metrics in White Matter tracts of Patients with Multiple Sclerosis
Multiple Sclerosis
P11 - Poster Session 11 (5:30 PM-6:30 PM)
6-016
Although loss of hand dexterity is a common finding in people with MS (pwMS), research is limited.
To identify areas of early white matter tract disruptions involved in hand dexterity in patients with relapsing remitting multiple sclerosis (RRMS).
Thirty RRMS patients underwent 3T MRI scan of whole brain. Diffusion tensor imaging (DTI) parameters of 37 white matter tracts were obtained. Fractional Anisotropy (FA) and Mean Diffusivity (MD) metrics were recorded, and findings were correlated clinically with dominant (D) and non-dominant (ND) hand dexterity through utilizing the nine-hole peg test (9HPT). Correlation analysis to identify significant relationships was performed in SPSS v29.

Mean age and disease duration of patients were 43.9±10.3 years and 6.0±7.9 years respectively, with a median expanded disability status scale (EDSS) of 1.5(1.5-3.4). Mean 9HPT scores were 23.8±8.5 seconds in the D and 26.4±9.0 seconds in the ND hand. The 9HPT-D dexterity score was positively correlated with MD in the left arcuate fasciculus (p < 0.001, r = 0.691), and negatively correlated with FA in the left arcuate fasciculus (p = 0.001, r = -0.570) and right dorsal longitudinal fasciculus (p = 0.003, r = -0.534).

In addition, 9HPT-ND dexterity score was positively correlated with MD in the right arcuate fasciculus (p < 0.001, r = 0.619), left arcuate fasciculus (p = 0.001, r = 0.586) and right cingulum (p = 0.001, r = 0.569). Moreover, it was negatively correlated with FA in the right medial lemniscus (p < 0.001, r = -0.620) and superior cerebellar peduncle (p = 0.003, r = -0.536).

Hand dexterity is a complex process and various white matter tracts are involved. More specifically, the left arcuate fasciculus appears to play an important role in dexterity in the D hand, while bilateral arcuate fasciculi contribute to dexterity of ND hand in pwMS.
Authors/Disclosures
Carla E. Santiago-Martinez (Wayne State University)
PRESENTER
Ms. Santiago-Martinez has nothing to disclose.
Sulafa G. Saffarini, MD (Detroit Medical Center) Dr. Saffarini has nothing to disclose.
Muhammad F. Raghib, MD (Wayne State University) Dr. Raghib has nothing to disclose.
Fen Bao No disclosure on file
Evanthia Bernitsas, MD, FAAN (Wayne State School of Medicine) Dr. Bernitsas has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Janssen@Janssen. Dr. Bernitsas has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Biogen. The institution of Dr. Bernitsas has received research support from Roche/Genentech.