2021 Annual Meeting | S20 - Motor Neuron Disease/Amyotrophic Lateral Sclerosis

Date Tuesday 04/20/21

Time 02:00 PM - 03:00 PM EDT Add To Calendar

Session Format This program will be presented both in-person and online

On Demand This program will be available in the meeting's On Demand product.

Event Type Scientific Platform Session

Topic(s) Neuromuscular and Clinical Neurophysiology (EMG)

CME Available 1.00 CME credit

Event Timeline
02:00 PM - 02:08 PM EDT	Abstract	001 - Design of a Phase 3, Randomized, Placebo-controlled Trial of Tofersen Initiated in Clinically Pre-symptomatic SOD1 Mutation Carriers with a Longitudinal Natural History Run-in Michael G. Benatar, MBChB, DPhil, FAAN
02:08 PM - 02:16 PM EDT	Abstract	002 - Clinical Utility of Whole-Genome Sequencing in an ALS Cohort Adriano Chio, MD, FAAN
02:16 PM - 02:24 PM EDT	Q&A	Questions and Answers
02:24 PM - 02:32 PM EDT	Abstract	003 - Determinants of clinical response to levosimendan in the REFALS phase 3 study in people with ALS Merit E. Cudkowicz, MD, MSC, FAAN
02:32 PM - 02:40 PM EDT	Abstract	004 - Metabolic Brain Changes Across Different Levels Of Cognitive Impairment In ALS: A 18F-FDG-PET Study Antonio Canosa
02:40 PM - 02:48 PM EDT	Abstract	005 - WVE-004, an investigational stereopure antisense oligonucleotide for the treatment of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) Yuanjing Liu
02:48 PM - 03:00 PM EDT	Q&A	Questions and Answers

Faculty Disclosures
Fangjun Liu	FANGJUN LIU has received personal compensation for serving as an employee of Wave Life Sciences. FANGJUN LIU has received stock or an ownership interest from Wave Life Sci.
Susovan Mohapatra	No disclosure on file
Chris Garratt	Chris Garratt has received personal compensation for serving as an employee of Orion Pharma.
Hailin Yang	Hailin Yang has received personal compensation for serving as an employee of Wave Life Sciences. Hailin Yang has received stock or an ownership interest from WAVE LIFE SCIENCES. Hailin Yang has received intellectual property interests from a discovery or technology relating to health care.
Erin Purcell-Estabrook	Erin Purcell-Estabrook has received personal compensation for serving as an employee of Wave Life Science. Erin Purcell-Estabrook has received stock or an ownership interest from Wave Life Science.
Janice Chun Yee Wong, MD	Dr. Wong has received personal compensation for serving as an employee of Janssen Research & Development. Dr. Wong has received personal compensation for serving as an employee of Biogen. Dr. Wong has stock in Biogen. Dr. Wong has stock in Janssen Research & Development.
Jinhui Ding	Jinhui Ding has nothing to disclose.
Peng Sun	Peng Sun has received personal compensation for serving as an employee of Biogen . Peng Sun has received stock or an ownership interest from Biogen.
Joanne Wuu, SCM	The institution of Ms. Wuu has received research support from NIH NINDS. The institution of Ms. Wuu has received research support from NIH NCATS/NINDS. The institution of Ms. Wuu has received research support from CDC. The institution of Ms. Wuu has received research support from Target ALS. The institution of Ms. Wuu has received research support from ALS Recovery Fund. The institution of Ms. Wuu has received research support from NIH/NINDS. The institution of Ms. Wuu has received research support from NIH NINDS. The institution of an immediate family member of Ms. Wuu has received research support from NIH NINDS.
J. Raphael Gibbs	J. Raphael Gibbs has received research support from NIH. The institution of J. Raphael Gibbs has received research support from Michael J Fox Foundation.
Jean Pierre Zucchetti	Jean Pierre Zucchetti has nothing to disclose.
Sonja Waltraud Scholz, MD, FAAN	Dr. Scholz has received personal compensation for serving as an employee of National Institutes of Health. An immediate family member of Dr. Scholz has received personal compensation for serving as an employee of National Institutes of Health. The institution of Dr. Scholz has received research support from National Institutes of Health. The institution of an immediate family member of Dr. Scholz has received research support from National Institutes of Health. An immediate family member of Dr. Scholz has received intellectual property interests from a discovery or technology relating to health care. Dr. Scholz has a non-compensated relationship as a Scientific Advisory Council Member with Lewy Body Dementia Association that is relevant to AAN interests or activities. Dr. Scholz has a non-compensated relationship as a Editorial Board Member with JAMA Neurology that is relevant to AAN interests or activities. Dr. Scholz has a non-compensated relationship as a Editorial Board Member with Journal of Parkinson's Disease that is relevant to AAN interests or activities.
Bob Bucelli, MD, PhD	Dr. Bucelli has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biogen . Dr. Bucelli has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Bucelli has stock in Neuroquestions.com. An immediate family member of Dr. Bucelli has stock in Neuroquestions.com. The institution of Dr. Bucelli has received research support from Biogen. The institution of Dr. Bucelli has received research support from Ionis.
Maura Brunetti	Maura Brunetti has nothing to disclose.
Weiping Chen	Weiping Chen has nothing to disclose.
Sandra D'Alfonso	Sandra D'Alfonso has nothing to disclose.
Toni Sarapohja	Toni Sarapohja has received personal compensation for serving as an employee of Orion Corporation.
Toby A. Ferguson, MD	Dr. Ferguson has received personal compensation for serving as an employee of Biogen. Dr. Ferguson has received stock or an ownership interest from Biogen.
Marco Pagani	Marco Pagani has nothing to disclose.
Saurabh Patil	Saurabh Patil has received personal compensation for serving as an employee of Wave life Sciences. An immediate family member of Saurabh Patil has received personal compensation for serving as an employee of Novartis Institutes for BioMedical Research. Saurabh Patil has received stock or an ownership interest from Wave Life Sciences.
Adriano Chio, MD, FAAN	Dr. Chio has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cytokinetics. Dr. Chio has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Mitsubishi. Dr. Chio has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen.
Nicholas J. Maragakis, MD, FAAN	Dr. Maragakis has received personal compensation in the range of $500-$4,999 for serving as a Consultant for UptoDate. Dr. Maragakis has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Apellis Pharmaceuticals. Dr. Maragakis has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amylyx. An immediate family member of Dr. Maragakis has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for National Basketball Association. Dr. Maragakis has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Akava. An immediate family member of Dr. Maragakis has received personal compensation in the range of $0-$499 for serving as an officer or member of the Board of Directors for Johns Hopkins Howard County Medical Center. Dr. Maragakis has stock in Akava. The institution of Dr. Maragakis has received research support from NIH/NINDS. The institution of Dr. Maragakis has received research support from Department of Defense. The institution of Dr. Maragakis has received research support from Maryland Stem Cell Research Fund. Dr. Maragakis has received intellectual property interests from a discovery or technology relating to health care.
Yuan Yin	Yuan Yin has received personal compensation for serving as an employee of Wave Life Sciences. Yuan Yin has received stock or an ownership interest from Wave Life Sciences.
Angela L. Genge, MD	Dr. Genge has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for AL-S Pharma. Dr. Genge has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Genge has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cytokinetics. Dr. Genge has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Amylyx. Dr. Genge has received personal compensation in the range of $100,000-$499,999 for serving as a Consultant for Quralis. Dr. Genge has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alexion. Dr. Genge has received personal compensation in the range of $500-$4,999 for serving as a Consultant for MTPA. Dr. Genge has received personal compensation in the range of $0-$499 for serving as a Consultant for WAVE.
Ruth Chia	Ruth Chia has nothing to disclose.
Stephanie Fradette	Stephanie Fradette has received personal compensation for serving as an employee of Biogen. Stephanie Fradette has received stock or an ownership interest from Biogen.
Michael G. Benatar, MBChB, DPhil, FAAN	Dr. Benatar has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biogen. The institution of Dr. Benatar has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Arrowhead. Dr. Benatar has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Alexion. Dr. Benatar has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Annexon. Dr. Benatar has received personal compensation in the range of $500-$4,999 for serving as a Consultant for UCB. Dr. Benatar has received personal compensation in the range of $500-$4,999 for serving as a Consultant for UniQure. Dr. Benatar has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Immunovant. Dr. Benatar has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cartesian. Dr. Benatar has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Horizon. Dr. Benatar has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. Dr. Benatar has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly. Dr. Benatar has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alector. Dr. Benatar has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Dr. Benatar has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Benatar has received intellectual property interests from a discovery or technology relating to health care.
Francesca Palumbo	Francesca Palumbo has nothing to disclose.
Bryan Traynor, MD	The institution of Dr. Traynor has received research support from ALS Association. The institution of Dr. Traynor has received research support from Merck. The institution of Dr. Traynor has received research support from Myasthenia Gravis Foundation. The institution of Dr. Traynor has received research support from Cerevel Therapeutics. Dr. Traynor has received intellectual property interests from a discovery or technology relating to health care.
Lucia *use 337449 Corrado	No disclosure on file
Valtteri Aho	Valtteri Aho has received personal compensation for serving as an employee of Orion Corporation.
Amy Andreucci	Amy Andreucci has received personal compensation for serving as an employee of Wave Life Sciences. Amy Andreucci has received stock or an ownership interest from Wave Life Sciences.
Letizia Mazzini	Letizia Mazzini has nothing to disclose.
Markus Otto	Markus Otto has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Markus Otto has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Axon Neuroscience. Markus Otto has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Markus Otto has a non-compensated relationship as a Sponor of research with Federal ministry of education and research that is relevant to AAN interests or activities.
Merit E. Cudkowicz, MD, MSC, FAAN	Dr. Cudkowicz has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for biogen. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for cytokinetics. Dr. Cudkowicz has received personal compensation in the range of $0-$499 for serving as a Consultant for als pharma. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for RRD. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for immunitypharm. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for denali. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for wave. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for transposon. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Quralis. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Regeneron. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for LIlly. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Takeda. Dr. Cudkowicz has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Faze. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for AB sciences. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for MTPC. Dr. Cudkowicz has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Neurosense. Dr. Cudkowicz has received personal compensation in the range of $0-$499 for serving as a Consultant for vectorY. Dr. Cudkowicz has received personal compensation in the range of $0-$499 for serving as a Consultant for Arrowhead. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Servier. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eledon. Dr. Cudkowicz has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Locust Walk. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Pasithea. Dr. Cudkowicz has received personal compensation in the range of $50,000-$99,999 for serving as an officer or member of the Board of Directors for Praxis Precision Medicine. Dr. Cudkowicz has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Annals of Neurology . An immediate family member of Dr. Cudkowicz has stock in Sqz. The institution of Dr. Cudkowicz has received research support from NINDS. The institution of Dr. Cudkowicz has received research support from ALSA . The institution of Dr. Cudkowicz has received research support from ALSFAC. The institution of Dr. Cudkowicz has received research support from UCB ra. The institution of Dr. Cudkowicz has received research support from Biohaven. The institution of Dr. Cudkowicz has received research support from Clene nanomedicine. The institution of Dr. Cudkowicz has received research support from prilenia. The institution of Dr. Cudkowicz has received research support from ALS one. The institution of Dr. Cudkowicz has received research support from Seelos. The institution of Dr. Cudkowicz has received research support from Calico. Dr. Cudkowicz has received publishing royalties from a publication relating to health care.
Laura Peotta	Laura Peotta has nothing to disclose.
Ammar Al-Chalabi, PhD, FRCP DipStat	The institution of Dr. Al-Chalabi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for OrionPharma. The institution of Dr. Al-Chalabi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cytokinetics Inc. The institution of Dr. Al-Chalabi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Mitsubishi Tanabe Pharma. The institution of Dr. Al-Chalabi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amylyx. The institution of Dr. Al-Chalabi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Quralis. Dr. Al-Chalabi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for My Name'5 Doddie Foundation. The institution of Dr. Al-Chalabi has received research support from Medical Research Council. The institution of Dr. Al-Chalabi has received research support from NIHR. The institution of Dr. Al-Chalabi has received research support from European Commission. The institution of Dr. Al-Chalabi has received research support from MND Association. The institution of Dr. Al-Chalabi has received research support from My Name'5 Doddie Foundation. Dr. Al-Chalabi has received publishing royalties from a publication relating to health care. Dr. Al-Chalabi has received publishing royalties from a publication relating to health care. Dr. Al-Chalabi has a non-compensated relationship as a SAB Member and Executive Member with TRICALS that is relevant to AAN interests or activities.
Laura Fanning	Laura Fanning has received personal compensation for serving as an employee of Biogen. Laura Fanning has received stock or an ownership interest from Biogen.
Yingying Liu	Yingying Liu has received personal compensation for serving as an employee of Biogen. Yingying Liu has received stock or an ownership interest from Biogen.
Fabiola De Marchi	Fabiola De Marchi has nothing to disclose.
Antonio Canosa	Antonio Canosa has nothing to disclose.
Yuanjing Liu	Yuanjing Liu has received personal compensation for serving as an employee of Wave life sciences . Yuanjing Liu has received stock or an ownership interest from Wave life sciences.
Jinsy Andrews, MD, FAAN	Dr. Andrews has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Andrews has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Wave Life Sciences. Dr. Andrews has received personal compensation in the range of $0-$499 for serving as a Consultant for Cytokinetics. Dr. Andrews has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Apellis . Dr. Andrews has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Revalasio . Dr. Andrews has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Denali . Dr. Andrews has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Orion . Dr. Andrews has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amylyx. Dr. Andrews has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis . Dr. Andrews has received personal compensation in the range of $500-$4,999 for serving as a Consultant for UCB. Dr. Andrews has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Orphazyme. Dr. Andrews has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for AL-S Pharma. Dr. Andrews has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Dr. Andrews has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Quralis . Dr. Andrews has received personal compensation in the range of $500-$4,999 for serving as an officer or member of the Board of Directors for Neurosense. Dr. Andrews has received personal compensation in the range of $0-$499 for serving as an officer or member of the Board of Directors for Akava. The institution of Dr. Andrews has received research support from Amylyx. The institution of Dr. Andrews has received research support from Biogen . The institution of Dr. Andrews has received research support from Cytokinetics . The institution of Dr. Andrews has received research support from NIH . The institution of Dr. Andrews has received research support from Biohaven/Platform Trial. The institution of Dr. Andrews has received research support from Clene/Platform Trial . The institution of Dr. Andrews has received research support from Ra Pharma/Platform Trial . The institution of Dr. Andrews has received research support from Prilenia/Platform Trial . Dr. Andrews has received research support from ALS Association . Dr. Andrews has a non-compensated relationship as a Board of Trustee Member with ALS Association that is relevant to AAN interests or activities. Dr. Andrews has a non-compensated relationship as a Co-Chair with Northeast ALS (NEALS) Consortium that is relevant to AAN interests or activities.
Andrea Calvo, MD, PhD, FAAN	Dr. Calvo has nothing to disclose.
Fabrizio D'Ovidio	Fabrizio D'Ovidio has nothing to disclose.
Maurizio Grassano, MD	Mr. Grassano has nothing to disclose.
Kristin Taborn	Kristin Taborn has received personal compensation for serving as an employee of Wave Life Sciences. Kristin Taborn has received stock or an ownership interest from Wave life sciences.
Clifton Dalgard	Clifton Dalgard has nothing to disclose.
Susanne Petri	Susanne Petri has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Biogen. Susanne Petri has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Roche. Susanne Petri has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Biogen. Susanne Petri has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Novartis. Susanne Petri has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Desitin. The institution of Susanne Petri has received research support from EU Joint Programme for Neurodegenerative Disease Research. The institution of Susanne Petri has received research support from German Neuromuscular Society. The institution of Susanne Petri has received research support from German Israeli Foundation (GIF).
Cristina Moglia	Cristina Moglia has nothing to disclose.
Leonard H. Van den Berg, MD	Dr. Van den Berg has nothing to disclose.
Elena Dale	Elena Dale has received personal compensation for serving as an employee of Wave Life Sciences. Elena Dale has received stock or an ownership interest from Wave life Sciences.
Vincenzo Arena	Vincenzo Arena has nothing to disclose.
Barbara Iazzolino	Barbara Iazzolino has nothing to disclose.
Umberto Manera, MD	Dr. Manera has nothing to disclose.
Rosario Vasta, MD	Dr. Vasta has nothing to disclose.
Maria Claudia Torrieri	Maria Claudia Torrieri has nothing to disclose.
Danielle Graham	Danielle Graham has received personal compensation for serving as an employee of Biogen. An immediate family member of Danielle Graham has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for NPP. Danielle Graham has received stock or an ownership interest from Biogen.
Peter Munch Andersen, MD	Prof. Andersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Prof. Andersen has received personal compensation in the range of $0-$499 for serving as a Consultant for Orphazyme A/S. Prof. Andersen has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Prof. Andersen has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Orphazyme A/S. The institution of Prof. Andersen has received research support from Swedish Research Council. The institution of Prof. Andersen has received research support from Swedish Brain Foundation. The institution of Prof. Andersen has received research support from KAW. The institution of Prof. Andersen has received research support from The Ulla-Carin Lindquist patient organization. The institution of Prof. Andersen has received research support from Umea University Research Foundation. The institution of Prof. Andersen has received research support from Swedish Neuro Patient Organization.
Chandra Vargeese	No disclosure on file
Lucia Corrado	Lucia Corrado has nothing to disclose.
Colin Quinn, MD	Dr. Quinn has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amylyx Pharmaceuticals. Dr. Quinn has received personal compensation in the range of $0-$499 for serving as a Consultant for Amicus. Dr. Quinn has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sarepta Therapeutics. Dr. Quinn has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Quinn has received personal compensation in the range of $0-$499 for serving as a Consultant for Clene Nanomedicine. Dr. Quinn has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Partners Health Care. Dr. Quinn has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Robins Kaplan.
Namita Goyal, MD, FAAN	Dr. Goyal has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion. Dr. Goyal has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genzyme. Dr. Goyal has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Argenx. Dr. Goyal has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for UCB . Dr. Goyal has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Astrazenica. Dr. Goyal has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Kezar. Dr. Goyal has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Annexon. Dr. Goyal has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Abcuro. Dr. Goyal has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Fulcrum. Dr. Goyal has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for CSL Behring. Dr. Goyal has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Argenx. The institution of Dr. Goyal has received research support from Brainstorm Cell Therapeutics. The institution of Dr. Goyal has received research support from Cytokinetics. The institution of Dr. Goyal has received research support from Fulcrum. The institution of Dr. Goyal has received research support from Kezar. The institution of Dr. Goyal has received research support from Alexion. The institution of Dr. Goyal has received research support from Annexon. The institution of Dr. Goyal has received research support from Annelixis. The institution of Dr. Goyal has received research support from Healey Platform. The institution of Dr. Goyal has received research support from Medicinova. The institution of Dr. Goyal has received research support from Amylyx. The institution of Dr. Goyal has received research support from MT Pharma. The institution of Dr. Goyal has received research support from Transposon. Dr. Goyal has received publishing royalties from a publication relating to health care.