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2022 Annual Meeting | S11 - ALS and Motor Neuron Disorders

Monday 04/04/22
01:00 PM - 03:00 PM PDT Add To Calendar
This program will be presented both in-person and online
This program will be available in the meeting's On Demand product.
Scientific Platform Session
Neuromuscular and Clinical Neurophysiology (EMG)
2.00 CME credits

Program Materials Program Evaluations

Event Timeline
01:00 PM - 01:24 PM PDT Speaker 2022 Sheila Essey Award: An Award for ALS Research: This award recognizes an individual who has made significant research contributions in the search for the cause, prevention of, and cure for amyotrophic lateral sclerosis (ALS).
Matthew Colm Kiernan, PhD, FRACP, MBBS
01:00 PM - 01:00 PM PDT Speaker walk in slides
Matthew Colm Kiernan, PhD, FRACP, MBBS
01:24 PM - 01:36 PM PDT Abstract 003 - Deciphering the Phenotype of ALS Patients with Intermediate ATXN2 PolyQ Expansion
Adriano Chio, MD, FAAN
01:36 PM - 01:48 PM PDT Abstract 004 - GBA Variants Influence Cognitive Status of ALS Patients
Adriano Chio, MD, FAAN
01:48 PM - 02:00 PM PDT Abstract 005 - Safety of a Fixed-Dose Coformulation of Sodium Phenylbutyrate and Taurursodiol in Amyotrophic Lateral Sclerosis and Alzheimer’s Disease: Integrated Clinical Trials Experience
Sabrina Paganoni, MD, PhD
02:00 PM - 02:12 PM PDT Abstract 006 - Unraveling the clinical and genetic spectrum of FUS-ALS
Maurizio Grassano, MD
02:12 PM - 02:24 PM PDT Abstract 007 - A Clinical Bulbar Assessment Scale for ALS/MND: Preliminary Validation
Gary L. Pattee, MD
02:24 PM - 02:36 PM PDT Abstract 008 - Using mfn2 Knockout Zebrafish as a Novel Model of ALS
Kristi Russell, PhD
02:36 PM - 02:48 PM PDT Abstract 009 - Clinical Outcomes in Primary Lateral Sclerosis: A Prospective Natural History Study
Eoin Finegan, MBBS
02:48 PM - 03:00 PM PDT Abstract 010 - Accurate Test of Limb Isometric Strength (ATLIS) as an Outcome Measure in ALS and as a Marker of Upper Motor Neuron Involvement in Primary Lateral Sclerosis
Samuel Frank, MD
Faculty Disclosures
Jamie Timmons, MD Dr. Timmons has received personal compensation for serving as an employee of Amylyx Pharmaceuticals. Dr. Timmons has stock in Amylyx Pharmaceuticals.
Antonio Canosa Antonio Canosa has nothing to disclose.
Salvatore Gallone, MD Dr. Gallone has nothing to disclose.
Matthew Burford, MD The institution of Dr. Burford has received research support from Brainstorm Cell Therapeutics. The institution of Dr. Burford has received research support from Pharnext Inc.
Alessandro Bombaci, MD Dr. Bombaci has nothing to disclose.
Maura Brunetti Maura Brunetti has nothing to disclose.
Rangariroyashe Chipika Miss Chipika has nothing to disclose.
Sandra D'Alfonso Sandra D'Alfonso has nothing to disclose.
Letizia Mazzini Letizia Mazzini has nothing to disclose.
Youstina Haidy Makary, Other Ms. Makary has nothing to disclose.
Robert H. Baloh, MD, PhD, FAAN Dr. Baloh has received personal compensation for serving as an employee of Roche. Dr. Baloh has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Acurastem. Dr. Baloh has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Irell. The institution of Dr. Baloh has received research support from NIH and CIRM.
Giorgia Brodini Ms. Brodini has nothing to disclose.
Patrick Yeramian Patrick Yeramian has received personal compensation for serving as an employee of Amylyx Pharmaceuticals.
Salvatore Gallone No disclosure on file
Stefan M. Pulst, MD, FAAN Dr. Pulst has received personal compensation in the range of $500-$4,999 for serving as a Consultant for venrock. Dr. Pulst has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Arrowhead. Dr. Pulst has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Leverna. Dr. Pulst has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for AAN. Dr. Pulst has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Leninthal LLC. The institution of Dr. Pulst has received research support from NINDS. Dr. Pulst has received intellectual property interests from a discovery or technology relating to health care.
Lucia Corrado Lucia Corrado has nothing to disclose.
Suzanne Hendrix, PhD Dr. Hendrix has received personal compensation for serving as an employee of Pentara Corporation. Dr. Hendrix has received personal compensation in the range of $50,000-$99,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Pentara Corporation. Dr. Hendrix has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Pentara Corporation. The institution of Dr. Hendrix has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Pentara Corporation. Dr. Hendrix has stock in Pentara.
Samuel Frank, MD Dr. Frank has nothing to disclose.
Sabrina Paganoni, MD, PhD Dr. Paganoni has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cytokinetics. Dr. Paganoni has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Jannsen. Dr. Paganoni has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Arrowhead. Dr. Paganoni has received personal compensation in the range of $0-$499 for serving as a Consultant for Sola. Dr. Paganoni has received personal compensation in the range of $0-$499 for serving as a Consultant for Frequency Therapeutics. The institution of Dr. Paganoni has received research support from Amylyx. The institution of Dr. Paganoni has received research support from Revalesio. The institution of Dr. Paganoni has received research support from Alector. The institution of Dr. Paganoni has received research support from UCB. The institution of Dr. Paganoni has received research support from Biohaven. The institution of Dr. Paganoni has received research support from Clene. The institution of Dr. Paganoni has received research support from Prilenia. The institution of Dr. Paganoni has received research support from Seelos. The institution of Dr. Paganoni has received research support from Calico. The institution of Dr. Paganoni has received research support from Denali. The institution of Dr. Paganoni has received research support from Anelixis. The institution of Dr. Paganoni has received research support from Cytokinetics.
Rosario Vasta, MD Dr. Vasta has nothing to disclose.
Eoin Finegan, MBBS Dr. Finegan has nothing to disclose.
Jessie Johnson, PhD The institution of Dr. Johnson has received personal compensation in the range of $0-$499 for serving as a Consultant for Pentara Corporation.
Peter Bede, MD, PhD Dr. Bede has nothing to disclose.
Ruth Chia Ruth Chia has nothing to disclose.
Mark B. Bromberg, MD, PhD, FAAN Dr. Bromberg has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Accordant Health. Dr. Bromberg has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Cytokinetics. Dr. Bromberg has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Alexion. Dr. Bromberg has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for MT Pharma. Dr. Bromberg has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Grifols. Dr. Bromberg has received publishing royalties from a publication relating to health care. Dr. Bromberg has received publishing royalties from a publication relating to health care. Dr. Bromberg has received publishing royalties from a publication relating to health care. Dr. Bromberg has received personal compensation in the range of $5,000-$9,999 for serving as a Medical reviewer with Department of Justice, Vaccination Compensation Board.
Sophia Katherine Mostowy Miss Mostowy has nothing to disclose.
Sara Cabras Sara Cabras has nothing to disclose.
Frank Diaz, MD, PhD Dr. Diaz has nothing to disclose.
Jinhui Ding Jinhui Ding has nothing to disclose.
Stacey Li Hi Shing Stacey Li Hi Shing has nothing to disclose.
Summer Gibson, MD An immediate family member of Dr. Gibson has received personal compensation for serving as an employee of Recursion Pharmaceuticals. Dr. Gibson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Guidepoint. An immediate family member of Dr. Gibson has received stock or an ownership interest from Recursion Pharmaceuticals . An immediate family member of Dr. Gibson has received intellectual property interests from a discovery or technology relating to health care. Dr. Gibson has received publishing royalties from a publication relating to health care.
Machelle Manuel, PhD Dr. Manuel has received personal compensation for serving as an employee of Amylyx Pharmaceuticals.
Shide Badri, MD Dr. Badri has nothing to disclose.
Fabiola De Marchi Fabiola De Marchi has nothing to disclose.
Richard A. Lewis, MD, FAAN Dr. Lewis has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Argenx. Dr. Lewis has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for CSL Behring. Dr. Lewis has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sanofi. Dr. Lewis has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Grifols. Dr. Lewis has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Takeda. Dr. Lewis has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Nuvig. Dr. Lewis has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Dianthus. Dr. Lewis has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Janssen. Dr. Lewis has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Medscape. Dr. Lewis has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion. Dr. Lewis has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Boehringer Ingelheim. Dr. Lewis has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alnylam. Dr. Lewis has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Lewis has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Shernoff et al. Dr. Lewis has received publishing royalties from a publication relating to health care.
Cristina Moglia Cristina Moglia has nothing to disclose.
Laura Ball No disclosure on file
Steven E. Arnold, MD Dr. Arnold has received personal compensation in the range of $500-$4,999 for serving as a Consultant for EIP Pharma. Dr. Arnold has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai. Dr. Arnold has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sage Therapeutics. Dr. Arnold has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Cortexyme. Dr. Arnold has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Boyle Shaughnessy Law. Dr. Arnold has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Wolf Greenfield. Dr. Arnold has received personal compensation in the range of $500-$4,999 for serving as a Advisory Board Member with Bob's Last Marathon.
J. Raphael Gibbs J. Raphael Gibbs has received research support from NIH. The institution of J. Raphael Gibbs has received research support from Michael J Fox Foundation.
Adriano Chio, MD, FAAN Dr. Chio has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cytokinetics. Dr. Chio has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Mitsubishi. Dr. Chio has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen.
Samuel *Use 397186 Dickson Samuel Dickson has received personal compensation for serving as an employee of Pentara Corporation.
Kristi Russell, PhD The institution of Mrs. Russell has received research support from Margolis Foundation.
Andrea Calvo, MD, PhD, FAAN Dr. Calvo has nothing to disclose.
Bryan Traynor, MD The institution of Dr. Traynor has received research support from ALS Association. The institution of Dr. Traynor has received research support from Merck. The institution of Dr. Traynor has received research support from Myasthenia Gravis Foundation. The institution of Dr. Traynor has received research support from Cerevel Therapeutics. Dr. Traynor has received intellectual property interests from a discovery or technology relating to health care.
Peggy Allred, PT Dr. Allred has received personal compensation for serving as an employee of Novartis. Dr. Allred has received stock or an ownership interest from Novartis.
Jon Downie, PhD Dr. Downie has nothing to disclose.
Clifton Dalgard Clifton Dalgard has nothing to disclose.
Umberto Manera, MD Dr. Manera has nothing to disclose.
Francesca Palumbo Francesca Palumbo has nothing to disclose.
Laura Peotta Laura Peotta has nothing to disclose.
Elizabeth Burton Elizabeth Burton has received personal compensation for serving as an employee of Madonna Rehabilitation Hospital.
Orla Hardiman, MD, FRCP, FAAN Dr. Hardiman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Wave Pharmaceuticals. Dr. Hardiman has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Cytokinetics . Dr. Hardiman has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Hardiman has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Taylor and Francis. The institution of Dr. Hardiman has received research support from Science Foundation Ireland. The institution of Dr. Hardiman has received research support from HRB.
Jenenne Geske The institution of Jenenne Geske has received research support from National Institutes of Health.
Lynn Jorde Lynn Jorde has nothing to disclose.
Newman Knowlton Newman Knowlton has received personal compensation for serving as an employee of Pentara Corporation.
Karla Patricia Figueroa Ms. Figueroa has nothing to disclose.
Giovanni De Marco, PhD Dr. De Marco has nothing to disclose.
Joshua Bonkowsky, MD, PhD Dr. Bonkowsky has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Denali. Dr. Bonkowsky has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Neurogene. Dr. Bonkowsky has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Passage Bio. Dr. Bonkowsky has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Autobahn. Dr. Bonkowsky has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sanofi. Dr. Bonkowsky has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Ionis. Dr. Bonkowsky has stock in Orchard. The institution of Dr. Bonkowsky has received research support from NIH. The institution of Dr. Bonkowsky has received research support from ELA. An immediate family member of Dr. Bonkowsky has received intellectual property interests from a discovery or technology relating to health care. Dr. Bonkowsky has received publishing royalties from a publication relating to health care. Dr. Bonkowsky has received publishing royalties from a publication relating to health care.
Merit E. Cudkowicz, MD, MSC, FAAN Dr. Cudkowicz has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for biogen. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for cytokinetics. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for immunitypharm. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for denali. The institution of Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for wave. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for transposon. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Quralis. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Regeneron. Dr. Cudkowicz has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Neurosense. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for vectorY. Dr. Cudkowicz has received personal compensation in the range of $0-$499 for serving as a Consultant for Arrowhead. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Servier. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eledon. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for inflectis. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for roche. Dr. Cudkowicz has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for novartis. Dr. Cudkowicz has received personal compensation in the range of $0-$499 for serving as a Consultant for ono. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for otsuka. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for coya. Dr. Cudkowicz has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Locust Walk. Dr. Cudkowicz has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Pasithea. Dr. Cudkowicz has received personal compensation in the range of $50,000-$99,999 for serving as an officer or member of the Board of Directors for Praxis Precision Medicine. Dr. Cudkowicz has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Annals of Neurology . An immediate family member of Dr. Cudkowicz has stock in Sqz. The institution of Dr. Cudkowicz has received research support from NINDS. The institution of Dr. Cudkowicz has received research support from ALSA . The institution of Dr. Cudkowicz has received research support from ALSFAC. The institution of Dr. Cudkowicz has received research support from UCB ra. The institution of Dr. Cudkowicz has received research support from Biohaven. The institution of Dr. Cudkowicz has received research support from Clene nanomedicine. The institution of Dr. Cudkowicz has received research support from prilenia. The institution of Dr. Cudkowicz has received research support from ALS one. The institution of Dr. Cudkowicz has received research support from Seelos. The institution of Dr. Cudkowicz has received research support from Calico. The institution of Dr. Cudkowicz has received research support from denali. The institution of Dr. Cudkowicz has received research support from ITB. Dr. Cudkowicz has received publishing royalties from a publication relating to health care.
Maurizio Grassano, MD Dr. Grassano has received research support from American Brain Foundation, ALS Association and American Academy of Neurology.
Jay W. Mason, MD Dr. Mason has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for HUYABio. Dr. Mason has received stock or an ownership interest from Spaulding Clinical.
Gary L. Pattee, MD The institution of Dr. Pattee has received personal compensation in the range of $500-$4,999 for serving as a Consultant for MTPA pharmaceuticals. The institution of Dr. Pattee has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for MTPA pharmaceiticals. The institution of Dr. Pattee has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Catalyst. The institution of Dr. Pattee has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for General Dynamics US military. The institution of Dr. Pattee has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Otsuka pharmaceuticals.
Barbara Iazzolino Barbara Iazzolino has nothing to disclose.
Matthew Colm Kiernan, PhD, FRACP, MBBS The institution of Prof. Kiernan has received personal compensation in the range of $50,000-$99,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for British Medical Journal Publishers (UK).
Colin Quinn, MD Dr. Quinn has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amylyx Pharmaceuticals. Dr. Quinn has received personal compensation in the range of $0-$499 for serving as a Consultant for Amicus. Dr. Quinn has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sarepta Therapeutics. Dr. Quinn has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Quinn has received personal compensation in the range of $0-$499 for serving as a Consultant for Clene Nanomedicine. Dr. Quinn has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Sanofi. Dr. Quinn has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Partners Health Care. Dr. Quinn has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Robins Kaplan.
Senda Ajroud-Driss, MD, FAAN Dr. Ajroud-Driss has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Amylyx Pharmaceuticals. Dr. Ajroud-Driss has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. The institution of Dr. Ajroud-Driss has received research support from ALSA. Dr. Ajroud-Driss has received publishing royalties from a publication relating to health care.