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2022 Annual Meeting | S20 - Aging and Dementia 2

Tuesday 04/05/22
01:00 PM - 03:00 PM PDT Add To Calendar
This program will be presented both in-person and online
This program will be available in the meeting's On Demand product.
Scientific Platform Session
Aging, Dementia, Cognitive, and Behavioral Neurology
2.00 CME credits

Program Materials Program Evaluations

Event Timeline
01:00 PM - 01:24 PM PDT Speaker 2022 Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases: This award recognizes major contributions to the understanding of the causes, prevention, treatment, and cure for Pick's, Alzheimer's, and related diseases.
Vladimir Hachinski, MD, DSc, FAAN
01:00 PM - 01:00 PM PDT Speaker Walk-in Slides
Vladimir Hachinski, MD, DSc, FAAN
01:24 PM - 01:36 PM PDT Abstract 003 - Head-to-head comparison of tau and amyloid PET visual reads for differential diagnosis: An international, multi-center study
David Nima Soleimani-Meigooni, MD
01:36 PM - 01:48 PM PDT Abstract 004 - Plasma Neurofilament Trajectories are Markers of Disease Progression and Severity in Genetic Frontotemporal Dementia
Dario Saracino
01:48 PM - 02:00 PM PDT Abstract 005 - Speech and Language Correlates of Decreased and Increased Functional Connectivity in Semantic Variant Primary Progressive Aphasia
Maxime Montembeault, PhD
02:00 PM - 02:12 PM PDT Abstract 006 - Frequent MAPT p.R406W Carriers with a Nonconforming FTD Phenotype in the Belgian Population
Helena Gossye
02:12 PM - 02:24 PM PDT Abstract 007 - Differences in rate and trajectory of TDP-43-associated neurodegeneration in brains with and without frontotemporal lobar degeneration
Marina Buciuc, MD
02:24 PM - 02:36 PM PDT Abstract 008 - Education, Early Life Socioeconomic Status, and Later Life Alzheimer’s Disease-Related Neuropathological Lesions
Amol Mehul Mehta, MD
02:36 PM - 02:48 PM PDT Abstract 009 - Dissecting the Neurodegenerative Causes of Rapidly Progressive Dementia: An Autopsy Study
Evelyn Lazar, MD
02:48 PM - 03:00 PM PDT Abstract 010 - Safety, Target Engagement and Effects of Bosutinib in Dementia with Lewy Bodies
Fernando L. Pagan, MD
Faculty Disclosures
Julie A. Schneider, MD, MS Dr. Schneider has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly. Dr. Schneider has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for alnylam. Dr. Schneider has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for apellis. Dr. Schneider has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for National Hockey League. The institution of Dr. Schneider has received research support from NIH. Dr. Schneider has received personal compensation in the range of $500-$4,999 for serving as a scientific advisor with Fondation Alzheimer, France.
Neill R. Graff-Radford, MD, FAAN The institution of Dr. Graff-Radford has received research support from Biogen. The institution of Dr. Graff-Radford has received research support from Lilly. The institution of Dr. Graff-Radford has received research support from Novartis. The institution of Dr. Graff-Radford has received research support from AbbVie. Dr. Graff-Radford has received publishing royalties from a publication relating to health care.
Jennifer Louise Whitwell, PhD Dr. Whitwell has nothing to disclose.
Peter P. De Deyn, MD,PhD Dr. De Deyn has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for elsevier.
David A. Bennett, MD Dr. Bennett has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Origent. Dr. Bennett has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for AbbVie. Dr. Bennett has received personal compensation in the range of $5,000-$9,999 for serving as a Study section, DMC, NACA Council with NIH. Dr. Bennett has received personal compensation in the range of $10,000-$49,999 for serving as a invited lectures with AMCs. Dr. Bennett has received personal compensation in the range of $5,000-$9,999 for serving as a invited paper with National Academy of Sciences. Dr. Bennett has received personal compensation in the range of $5,000-$9,999 for serving as a lecture with National Academy of Neuropsychology.
Leonardo Iaccarino Leonardo Iaccarino has nothing to disclose.
Ruben Smith, MD,PhD An immediate family member of Dr. Smith has received personal compensation for serving as an employee of Alligator Bioscience. The institution of Dr. Smith has received research support from EU - JPND. The institution of Dr. Smith has received research support from Alzheimerfonden. An immediate family member of Dr. Smith has received intellectual property interests from a discovery or technology relating to health care.
Marina Buciuc, MD Dr. Buciuc has nothing to disclose.
Maarten Goethals, MD Dr. Goethals has nothing to disclose.
Paul Crane An immediate family member of Paul Crane has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Viiv. The institution of an immediate family member of Paul Crane has received research support from Viiv. Paul Crane has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant with CUNY Queens Colege.
Isabelle Le Ber No disclosure on file
Amelia Strom Amelia Strom has nothing to disclose.
Dalila Ferrante No disclosure on file
Jean-Christophe Bier, Sr., MD Dr. Bier has nothing to disclose.
Peter Martin Mr. Martin has nothing to disclose.
Sara Matar Sara Matar has nothing to disclose.
Sara Van Mossevelde The institution of Ms. Van Mossevelde has received research support from King Baudouin Foundation - Fund Mr and Ms Deelen-Hollanders.
Olivier Colliot No disclosure on file
Renaud La Joie The institution of Renaud La Joie has received research support from NIH. The institution of Renaud La Joie has received research support from Alzheimer's Association.
Jenneke Van Den Ende Jenneke Van Den Ende has nothing to disclose.
David Nima Soleimani-Meigooni, MD Dr. Soleimani-Meigooni has nothing to disclose.
Peter Pressman, MD The institution of Dr. Pressman has received research support from the Doris Duke Fund to Retain Clinical Scientists . Dr. Pressman has received personal compensation in the range of $100,000-$499,999 for serving as a Associate Professor with University of Colorado School of Medicine.
Zachary Miller, MD Dr. Miller has nothing to disclose.
Keith A. Josephs, Jr., MD, FAAN Dr. Josephs has nothing to disclose.
Maria Luisa Gorno Tempini, MD, PhD The institution of Dr. Gorno Tempini has received research support from NIH.
Nina Dronkers, PhD The institution of Dr. Dronkers has received research support from NIH. Dr. Dronkers has received personal compensation in the range of $500-$4,999 for serving as a grants reviewer with NIH.
Joseph E. Parisi, MD Dr. Parisi has nothing to disclose.
Philip De Jager, MD, PhD Dr. De Jager has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biogen. Dr. De Jager has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Puretech. Dr. De Jager has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for roche. Dr. De Jager has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for biogen. The institution of Dr. De Jager has received research support from roche. The institution of Dr. De Jager has received research support from Biogen. The institution of Dr. De Jager has received research support from puretech.
Olivier Deryck Olivier Deryck has received personal compensation in the range of $0-$499 for serving as a Consultant for Novartis. Olivier Deryck has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen Idec, Roche.
Richard Levy Richard Levy has nothing to disclose.
Matthew Senjem Matthew Senjem has received stock or an ownership interest from Align Technology, Inc.. Matthew Senjem has received stock or an ownership interest from Inovio Biomedical Corp.. Matthew Senjem has received stock or an ownership interest from Johnson & Johnson. Matthew Senjem has received stock or an ownership interest from Mesa Laboratories, Inc.. Matthew Senjem has received stock or an ownership interest from Nvidia Inc.. Matthew Senjem has received stock or an ownership interest from LHC Group, Inc.. Matthew Senjem has received stock or an ownership interest from Natus Medical Incorporated. Matthew Senjem has received stock or an ownership interest from Varex Imaging Corporation. Matthew Senjem has received personal compensation in the range of $100,000-$499,999 for serving as a IT Technical Specialist II with Mayo Clinic.
Rik Ossenkoppele No disclosure on file
Ross Reichard The institution of Ross Reichard has received research support from NIH. An immediate family member of Ross Reichard has received publishing royalties from a publication relating to health care.
Chul Hyoung Lyoo, MD,PhD Dr. Lyoo has nothing to disclose.
Daisy Rinaldi Daisy Rinaldi has nothing to disclose.
Giovanni Battistella Giovanni Battistella has nothing to disclose.
Evelyn Lazar, MD Dr. Lazar has nothing to disclose.
Nirubol Tosakulwong Nirubol Tosakulwong has nothing to disclose.
Jan L. De Bleecker, MD, PhD, FAAN Dr. De Bleecker has received personal compensation in the range of $500-$4,999 for serving as a Consultant for ArgNX. Dr. De Bleecker has received personal compensation in the range of $0-$499 for serving as a Consultant for Biogen. Dr. De Bleecker has received personal compensation in the range of $500-$4,999 for serving as a Consultant for UCB. Dr. De Bleecker has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Dr. De Bleecker has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. De Bleecker has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for CSL Behring. Dr. De Bleecker has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for UCB. Dr. De Bleecker has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Alnylam. Dr. De Bleecker has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Janssen pharmaceuticals.
Dario Saracino Dario Saracino has nothing to disclose.
Clifford R. Jack, Jr., MD The institution of Dr. Jack has received research support from NIH. The institution of Dr. Jack has received research support from Alexander Family Alzheimer's Disease Research Professorship of the Mayo Clinic.
Marion Houot Mrs. Houot has nothing to disclose.
Olof Strandberg, PhD Mr. Strandberg has nothing to disclose.
Melissa Murray, PhD Dr. Murray has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Avid Radiopharmaceuticals. The institution of Dr. Murray has received research support from National Institute on Aging. The institution of Dr. Murray has received research support from Alzheimer's Association. The institution of Dr. Murray has received research support from Chan Zuckerberg Initiative.
Bradley F. Boeve, MD, FAAN Dr. Boeve has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for Rainwater Charitable Foundation. The institution of Dr. Boeve has received research support from Alector. The institution of Dr. Boeve has received research support from EIP Pharma. The institution of Dr. Boeve has received research support from Transposon. The institution of Dr. Boeve has received research support from Cognition Therapeutics. Dr. Boeve has received publishing royalties from a publication relating to health care.
Amol Mehul Mehta, MD Dr. Mehta has nothing to disclose.
Shanu Roemer Shanu Roemer has nothing to disclose.
Claire Boutoleau-Bretonniere, MD No disclosure on file
Florence Pasquier, MD Dr. Pasquier has nothing to disclose.
Mira Didic, MD No disclosure on file
Helena Gossye Mrs. Gossye has nothing to disclose.
Anthony Spychalla Anthony Spychalla has nothing to disclose.
Jan Versijpt Jan Versijpt has nothing to disclose.
Karine Provost, MD Dr. Provost has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Optina Diagnostics Inc.. Dr. Provost has received personal compensation in the range of $0-$499 for serving as a Consultant for Biospective Inc..
Karim Dorgham, PhD Dr. Dorgham has nothing to disclose.
Hanna Cho, MD, PhD No disclosure on file
Julie Van Der Zee No disclosure on file
Jeremie Pariente No disclosure on file
Nikhil Bharat Ghayal, Other Mr. Ghayal has nothing to disclose.
David S. Knopman, MD, FAAN Dr. Knopman has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for DIAN TU study. The institution of Dr. Knopman has received research support from NIH.
Paul M. Bourgeois, MD Dr. Bourgeois has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for ABBVIE.
Leonard Petrucelli, 10898 No disclosure on file
Ronald C. Petersen, PhD, MD, FAAN Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genentech. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Nestle. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly and Co.. Dr. Petersen has received personal compensation in the range of $0-$499 for serving as a Consultant for Eisai, Inc.. Dr. Petersen has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genentech, Inc.. Dr. Petersen has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche, Inc.. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Petersen has a non-compensated relationship as a Board of Directors with American Brain Foundation that is relevant to AAN interests or activities.
Stephanie Izard No disclosure on file
Sebastiaan Engelborghs, MD, PhD No disclosure on file
Agnes Camuzat Miss Camuzat has nothing to disclose.
Orit Lesman-Segev No disclosure on file
Christine Van Broeckhoven, PhD Dr. Van Broeckhoven has nothing to disclose.
Gil Dan Rabinovici, MD, FAAN Dr. Rabinovici has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Eli Lilly. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alector. Dr. Rabinovici has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Merck. Dr. Rabinovici has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Johnson & Joihnson. Dr. Rabinovici has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for JAMA Neurology. The institution of Dr. Rabinovici has received research support from NIH. The institution of Dr. Rabinovici has received research support from American College of Radiology. The institution of Dr. Rabinovici has received research support from Alzheimer's Association. The institution of Dr. Rabinovici has received research support from Rainwater Charitable Foundation. The institution of Dr. Rabinovici has received research support from Genentech. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving as a Topic Chair, Course Director and teacher with AAN. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving as a Grant reviewer with NIH. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving as a Invited speaker with ANA.
Dennis W. Dickson, MD Dr. Dickson has nothing to disclose.
Jaeil Ahn Jaeil Ahn has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for KeiferX.
Lauren Edwards Lauren Edwards has nothing to disclose.
Sarah Tom The institution of Sarah Tom has received research support from National Institutes of Health . Sarah Tom has received personal compensation in the range of $500-$4,999 for serving as a Consultant with Alzheimer's Association .
Fernando L. Pagan, MD Dr. Pagan has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Acorda. Dr. Pagan has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Adamas. Dr. Pagan has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Amneal. Dr. Pagan has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Merz. Dr. Pagan has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Kyowa Kirin. Dr. Pagan has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sunovion. Dr. Pagan has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Teva. Dr. Pagan has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for US World Meds. Dr. Pagan has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Supernus. Dr. Pagan has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Abbvie. Dr. Pagan has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Acorda. Dr. Pagan has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Adamas. Dr. Pagan has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Amneal. Dr. Pagan has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Sunovion. Dr. Pagan has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Teva. Dr. Pagan has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Neurocrine. Dr. Pagan has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Sunovion. Dr. Pagan has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Supernus. Dr. Pagan has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Journal of Clinical Parkinsonism and related Disorders. Dr. Pagan has stock in Keiferx. The institution of Dr. Pagan has received research support from US World Meds. The institution of Dr. Pagan has received research support from Novartis.
Bruce L. Miller, MD, FAAN Dr. Miller has nothing to disclose.
Gregory S. Day, MD, MSc, FAAN Dr. Day has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Parabon Nanolabs. The institution of Dr. Day has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Eli Lilly. Dr. Day has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Arialys Therapeutics. Dr. Day has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Ionis. Dr. Day has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for DynaMed (EBSCO Health). Dr. Day has stock in ANI Pharmaceuticals. The institution of Dr. Day has received research support from National Institutes of Health / NIA. The institution of Dr. Day has received research support from Chan Zuckerberg Initiative. The institution of Dr. Day has received research support from Alzheimer's Association. The institution of Dr. Day has received research support from National Institutes of Health / NINDS. The institution of Dr. Day has received research support from Horizon Therapeutics. The institution of Dr. Day has received research support from AVID Radiopharmaceuticals. Dr. Day has received personal compensation in the range of $500-$4,999 for serving as a Presenter at Annual Meeting (CME) with American Academy of Neurology. Dr. Day has received personal compensation in the range of $500-$4,999 for serving as a Content Development (CME) with PeerView, Inc. Dr. Day has received personal compensation in the range of $5,000-$9,999 for serving as a Content Development (CME) with Continuing Education, Inc. Dr. Day has a non-compensated relationship as a Clinical Director with AntiNMDA Receptor Encephalitis Foundation that is relevant to AAN interests or activities.
Maxime Montembeault, PhD Maxime Montembeault has nothing to disclose.
Yasar Alejandro Torres-Yaghi, MD Dr. Torres-Yaghi has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Acorda. Dr. Torres-Yaghi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Abbvie. Dr. Torres-Yaghi has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Amneal. Dr. Torres-Yaghi has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Abbott. Dr. Torres-Yaghi has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Kyowa Kirin. Dr. Torres-Yaghi has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Teva. Dr. Torres-Yaghi has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Sunovion .
Simona M. Brambati, MD No disclosure on file
Armelle Rametti Lacroux, Sr., PhD Dr. Rametti Lacroux has nothing to disclose.
Oskar Hansson, MD,PhD Prof. Hansson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Prof. Hansson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche.
Maria Luisa Mandelli Maria Luisa Mandelli has nothing to disclose.
Anne Sieben, MD Dr. Sieben has nothing to disclose.
Amandine Geraudie, MD Mrs. Geraudie has nothing to disclose.
Michaeline Hebron No disclosure on file
Philippe Couratier, PhD Dr. Couratier has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Couratier has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. Dr. Couratier has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier .
Maria Bjerke, PhD Prof. Bjerke has nothing to disclose.
Antoine Slegers Mr. Slegers has received personal compensation for serving as an employee of CIUSSS de l'Est-de-l'Île de Montréal. Mr. Slegers has received research support from CRNSG.
Vladimir Hachinski, MD, DSc, FAAN Dr. Hachinski has nothing to disclose.
Charbel E H Moussa, MB, PhD Dr. Moussa has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for KeifeRX LLC. Dr. Moussa has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sun Pharmaceuticals Research Industry. Dr. Moussa has received stock or an ownership interest from Orphan Therapeutics. The institution of Dr. Moussa has received research support from NIA. The institution of Dr. Moussa has received research support from Sun Pharmaceuticals Research Industry. The institution of Dr. Moussa has received research support from Alzheimer's Association . Dr. Moussa has received intellectual property interests from a discovery or technology relating to health care. Dr. Moussa has received intellectual property interests from a discovery or technology relating to health care. Dr. Moussa has received publishing royalties from a publication relating to health care. Dr. Moussa has received personal compensation in the range of $500-$4,999 for serving as a Grant reviewer with DG Information Technology. Dr. Moussa has received personal compensation in the range of $0-$499 for serving as a Peer Reviews with National Institutes of Health.
Raymond Turner No disclosure on file
Barbara Wilmarth Barbara Wilmarth has nothing to disclose.