2023 Annual Meeting | S26 - Experimental Therapeutics in Dementia

Date Tuesday 04/25/23

Time 01:00 PM - 03:00 PM EST Add To Calendar

Session Format This program will be presented both in-person and online

On Demand This program will be available in the meeting's On Demand product.

Event Type Scientific Platform Session

Moderator(s) Sharon Sha, MD, Julio C. Rojas-Martinez, MD, PhD

Topic(s) Aging, Dementia, and Behavioral Neurology

Learning Objectives A group of abstracts covering a similar topic presented in an oral format. Presentations are eight minutes in length with four minutes for question and answer with the author.

CME Available 2.00 CME credits

Recommended Audience Fellow, Resident, General Neurologist, Specialist Neurologist, Non-neurologist, Advanced Practice Provider, Neurohospitalist, Medical Student

Teaching Styles Didactic

Event Timeline
01:00 PM - 01:24 PM EST	Speaker	2023 Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases: This award recognizes major contributions to the understanding of the causes, prevention, treatment, and cure for Pick's, Alzheimer's, and related diseases. Maria Luisa Gorno Tempini, MD, PhD
01:36 PM - 01:48 PM EST	Abstract	004 - Rational design of a vaccine for Alzheimer’s disease using computationally-derived conformational B cell epitopes to selectively target toxic amyloid-beta oligomers Johanne M. Kaplan, PhD
01:48 PM - 02:00 PM EST	Abstract	005 - Using Predictive Models to Reduce Heterogeneity in Alzheimer’s Disease Clinical Trials Ali Ezzati, MD
02:00 PM - 02:12 PM EST	Abstract	006 - ALUMNI AD Study Design: Evaluation of Subcutaneous Gantenerumab in Historically Underrepresented US Populations With Early Symptomatic Alzheimer’s Disease Sheila Seleri
02:12 PM - 02:24 PM EST	Abstract	007 - Effects of ALZ-801, an Oral Amyloid Oligomer Inhibitor, on Biomarkers of Alzheimer’s Disease (AD): 12-Month Results of Phase 2 Biomarker Study in Early AD John A. Hey, PhD
02:24 PM - 02:36 PM EST	Abstract	008 - Fosgonimeton Provides Congruent Improvements on Neurodegeneration Biomarkers, Significantly Correlating With Composite Clinical Score of Cognition and Function in Alzheimer’s Disease Hans J. Moebius, MD, PhD, FAAN
02:36 PM - 02:48 PM EST	Abstract	009 - TRAILBLAZER-ALZ 4: Topline study results directly comparing donanemab to aducanumab on amyloid lowering in early, symptomatic Alzheimer’s disease Stephen P. Salloway, MD, MS
02:48 PM - 03:00 PM EST	Abstract	010 - GRADUATE I AND II: Findings of Two Phase III Randomized Placebo-controlled Studies Assessing the Efficacy and Safety of Subcutaneous Gantenerumab in Early Alzheimer’s Disease (AD) Janice W. Smith, PhD

Faculty Disclosures
	No disclosure on file
Charles Bernick, MD	Dr. Bernick has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lilly. Dr. Bernick has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Optina. Dr. Bernick has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eisai. Dr. Bernick has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Corium. Dr. Bernick has stock in Aurora. The institution of Dr. Bernick has received research support from UFC. The institution of Dr. Bernick has received research support from Top Rank Promotions. The institution of Dr. Bernick has received research support from Haymon Boxing.
Helen C. Lin, MD	Dr. Lin has received personal compensation for serving as an employee of Genentech. Dr. Lin has stock in Genentech.
Emer McGrath, MBChB	Dr. McGrath has nothing to disclose.
Ming Lu	No disclosure on file
Niels D. Prins, MD	Dr. Prins has stock in Brain Research Center. Dr. Prins has received personal compensation in the range of $100,000-$499,999 for serving as a CEO with Brain Research Center.
Claudia L. Satizabal, PhD	The institution of Dr. Satizabal has received research support from NIH and TARCC.
Emily Collins	No disclosure on file
Stephen P. Salloway, MD, MS	Dr. Salloway has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Biogen. Dr. Salloway has received personal compensation in the range of $500-$4,999 for serving as a Consultant for EISAI. Dr. Salloway has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Lilly. Dr. Salloway has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Genentech. Dr. Salloway has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for NovoNordisk. Dr. Salloway has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Prothena. Dr. Salloway has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amylyx. Dr. Salloway has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Roche. Dr. Salloway has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Ono. Dr. Salloway has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bolden. Dr. Salloway has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for EISAI. Dr. Salloway has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Acumen. Dr. Salloway has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lilly.
Michael G. Case, MS	Mr. Case has received personal compensation for serving as an employee of Eli Lilly and Company. Mr. Case has received stock or an ownership interest from Eli Lilly and Company.
Alexa Beiser	No disclosure on file
Kaj Blennow	No disclosure on file
Aidan Power, PhD	Dr. Power has received personal compensation for serving as an employee of Alzheon. Dr. Power has stock in Pfizer. Dr. Power has stock in Alzheon.
Johanne M. Kaplan, PhD	Dr. Kaplan has received personal compensation for serving as an employee of ProMIS Neurosciences. Dr. Kaplan has stock in ProMIS Neurosciences. Dr. Kaplan has received intellectual property interests from a discovery or technology relating to health care.
Sandra E. Black, MD, FAAN	Dr. Black has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Hoffmann-La Roche. Dr. Black has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Black has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Hoffmann-La Roche. Dr. Black has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Black has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eisai Limited . Dr. Black has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eli Lilly. Dr. Black has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Biogen. The institution of Dr. Black has received research support from Hoffmann-La Roche. The institution of Dr. Black has received research support from Biogen. The institution of Dr. Black has received research support from GE Healthcare. The institution of Dr. Black has received research support from Eli Lilly. The institution of Dr. Black has received research support from Genentech. The institution of Dr. Black has received research support from NovoNordisk. The institution of Dr. Black has received research support from UCB Biopharma. The institution of Dr. Black has received research support from Alkahest Inc. The institution of Dr. Black has received research support from University of Southern California - AHEAD 3-45 Study.
Bhargav Nallapu	No disclosure on file
Margaret Ferguson	Margaret Ferguson has received personal compensation for serving as an employee of Eli Lilly. Margaret Ferguson has stock in Eli Lilly.
Timo Grimmer, MD	Dr. Grimmer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for AbbVie, Alector, Anavex, Biogen, Eli Lilly, Functional Neuromodulation, Grifols, Iqvia, Noselab, Novo Nordisk, NuiCare, Orphanzyme, Roche Diagnostics, Roche Pharma, UCB, and Vivoryon. Dr. Grimmer has received personal compensation in the range of $500-$4,999 for serving as a lecturer with Grifols, Medical Tribune, Novo Nordisk, Roche Pharma, and Schwabe.
Rosalind Mandelbaum, PA	No disclosure on file
Ali Ezzati, MD	Dr. Ezzati has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Mist Research. Dr. Ezzati has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for BioDelivery Sciences International (BDSI) . The institution of Dr. Ezzati has received research support from NIA. The institution of Dr. Ezzati has received research support from Alzheimer's Association. The institution of Dr. Ezzati has received research support from Cure Alzheimer's Fund.
Richard B. Lipton, MD, FAAN	Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Allergan/Abbvie. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Amgen. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Biohaven. Dr. Lipton has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for Eli Lilly. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Lundbeck. Dr. Lipton has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for GlaxoSmithKline. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Teva. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Vedanta. Dr. Lipton has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Grifols. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Pfizer. Dr. Lipton has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Axon. Dr. Lipton has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Satsuma. Dr. Lipton has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genentech. Dr. Lipton has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cool Tech. Dr. Lipton has received personal compensation in the range of $500-$4,999 for serving as a Consultant for BDSI. Dr. Lipton has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Linpharma. Dr. Lipton has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Allergan/Abbvie. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biohaven. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eli Lilly. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lundbeck. Dr. Lipton has stock in Biohaven. Dr. Lipton has stock in Manistee. Dr. Lipton has stock in Axon. Dr. Lipton has stock in CoolTech. The institution of Dr. Lipton has received research support from Teva. The institution of Dr. Lipton has received research support from Amgen. The institution of Dr. Lipton has received research support from Allergan/Abbvie. The institution of Dr. Lipton has received research support from Gammacore. The institution of Dr. Lipton has received research support from Axsome. The institution of Dr. Lipton has received research support from Charleston Labs. The institution of Dr. Lipton has received research support from Eli Lilly. The institution of Dr. Lipton has received research support from Satsuma. The institution of Dr. Lipton has received research support from NIH . The institution of Dr. Lipton has received research support from Veterans Administration. Dr. Lipton has received publishing royalties from a publication relating to health care.
Alexandria Wise-Brown, PhD	Dr. Wise-Brown has received personal compensation for serving as an employee of Genentech.
Dawn Brooks	No disclosure on file
Paulo P. Fontoura, MD, PhD, FAAN	Dr. Fontoura has received personal compensation for serving as an employee of F. Hoffmann La Roche. Dr. Fontoura has stock in Roche Pharmaceuticals.
Ruiqi Wang	No disclosure on file
Sharay Setti	No disclosure on file
Janice W. Smith, PhD	Dr. Smith has received personal compensation for serving as an employee of Roche Products Ltd. Dr. Smith has stock in Hoffman La Roche.
Sheila Seleri	Sheila Seleri has received personal compensation for serving as an employee of Genentech, a member of the Roche group. Sheila Seleri has stock in Genentech, a member of the Roche group.
Jacobo E. Mintzer	Jacobo E. Mintzer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for AARP - Global Council on Brain Health. Jacobo E. Mintzer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for AARP - "Staying Sharp" Scientific Advisory Board. Jacobo E. Mintzer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for ACADIA. Jacobo E. Mintzer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genentech (affiliate of F. Hoffmann-La Roche Ltd). Jacobo E. Mintzer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Health and Wellness Partners, LLC. Jacobo E. Mintzer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Ironshore Pharmaceuticals. Jacobo E. Mintzer has received personal compensation in the range of $0-$499 for serving as a Consultant for Praxis Bioresearch. Jacobo E. Mintzer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sygnature Discovery. Jacobo E. Mintzer has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for AARP - "Staying Sharp" Scientific Advisory Board. Jacobo E. Mintzer has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Study Title: NAB-It: Nabilone for Agitation Blinded Intervention Trial. Jacobo E. Mintzer has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Study Title: WeCareAdvisory Study. Jacobo E. Mintzer has received personal compensation in the range of $0-$499 for serving as an officer or member of the Board of Directors for Technology Accelerator Company (TAC). Jacobo E. Mintzer has stock in Biopharma Connex. Jacobo E. Mintzer has stock in NeuroQuest. Jacobo E. Mintzer has stock in Recruitment Partners. The institution of Jacobo E. Mintzer has received research support from Eisai Inc.. The institution of Jacobo E. Mintzer has received research support from Alzheimer's Clinical Trials Consortium. The institution of Jacobo E. Mintzer has received research support from Eli Lilly and Company. The institution of Jacobo E. Mintzer has received research support from Alzheimer's Therapeutic Research Institute. The institution of Jacobo E. Mintzer has received research support from JHSPH Center for Clinical Trials. Jacobo E. Mintzer has received personal compensation in the range of $0-$499 for serving as a Steering Committee Member with Alzheimer's Clinical Trials Consortium (ACTC). Jacobo E. Mintzer has received personal compensation in the range of $0-$499 for serving as a Steering Committee Member with Alzheimer's Disease Cooperative Study (ADCS). Jacobo E. Mintzer has received personal compensation in the range of $0-$499 for serving as a Steering Committee Member with Elder Court. Jacobo E. Mintzer has received personal compensation in the range of $0-$499 for serving as a Unpaid Consultant/Association Member with International Psychogeriatric Association (IPA).
Saptaparni Ghosh	No disclosure on file
Michael Grundman, MD, MPH	Dr. Grundman has received personal compensation for serving as an employee of Global R&D Partners.
Michael Hale	No disclosure on file
Frederik Barkhof, MD, PhD	Frederik Barkhof has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Frederik Barkhof has received personal compensation in the range of $0-$499 for serving as a Consultant for Biogen. Frederik Barkhof has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Combinostics. Frederik Barkhof has received personal compensation in the range of $500-$4,999 for serving as a Consultant for IXICO. Frederik Barkhof has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. Frederik Barkhof has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for EISAI.
Hong Wang	No disclosure on file
Neil Cashman, MD	Dr. Cashman has received personal compensation for serving as an employee of ProMIS Neurosciences. Dr. Cashman has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Mitsubishi-Tanabe. Dr. Cashman has stock in ProMIS Neurosciences. The institution of Dr. Cashman has received research support from ProMIS Neurosciences. Dr. Cashman has received intellectual property interests from a discovery or technology relating to health care. Dr. Cashman has a non-compensated relationship as a BoD memeber with ALS Society of BC that is relevant to AAN interests or activities.
Ladislav Pazdera, MD, FAAN	Dr. Pazdera has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Pazdera has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Teva.
Ebrima Gibbs, Bsc, BMLSc, MSc	Dr. Gibbs has nothing to disclose.
Martin Tolar, MD, PhD	Dr. Tolar has received personal compensation for serving as an employee of Alzheon. Dr. Tolar has received intellectual property interests from a discovery or technology relating to health care.
Sudha Seshadri, MD, FAAN	Dr. Seshadri has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai. Dr. Seshadri has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. The institution of Dr. Seshadri has received research support from NIH. The institution of Dr. Seshadri has received research support from Alzheimer Association.
Gregory A. Rippon, MD, FAAN	Dr. Rippon has received personal compensation for serving as an employee of Genentech. Dr. Rippon has stock in Genentech.
Philip Scheltens, MD, PhD, FAAN	Dr. Scheltens has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for NOVO NOrdisk.
Kellen Petersen	No disclosure on file
Kayla Kleist	No disclosure on file
Kai-Bin Ooi	No disclosure on file
Paul L. Dautzenberg, PhD	Dr. Dautzenberg has nothing to disclose.
Russell Tracy	No disclosure on file
Jakub Hort, MD	Dr. Hort has received personal compensation in the range of $0-$499 for serving as a Consultant for Alzheimerchain. Dr. Hort has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Hort has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Schwabe. Dr. Hort has stock in Alzheon.
Qiong Yang	No disclosure on file
Rachelle S. Doody, MD, PhD	Dr. Doody has received personal compensation for serving as an employee of F. Hoffman-LaRoche. Dr. Doody has stock in F. Hoffman-LaRoche.
John R. Sims, MD	Dr. Sims has received personal compensation for serving as an employee of Eli Lilly and Company. Dr. Sims has stock in Eli Lilly and Company.
John A. Hey, PhD	Dr. Hey has received personal compensation for serving as an employee of Alzheon. Dr. Hey has stock in Alzheon. Dr. Hey has stock in Alzheon. Dr. Hey has received intellectual property interests from a discovery or technology relating to health care.
Sawsan (Susan) R. Abushakra, MD	Dr. Abushakra has received personal compensation for serving as an employee of Alzheon Inc. Dr. Abushakra has stock in Alzheon Inc. The institution of Dr. Abushakra has received research support from NIA. Dr. Abushakra has received intellectual property interests from a discovery or technology relating to health care.
Hans J. Moebius, MD, PhD, FAAN	Dr. Moebius has received personal compensation in the range of $100,000-$499,999 for serving as an officer or member of the Board of Directors for Athira Pharma, Inc.. Dr. Moebius has stock in Athira Pharma, Inc..
Maria Luisa Gorno Tempini, MD, PhD	The institution of Dr. Gorno Tempini has received research support from NIH.
Sharon Sha, MD	Dr. Sha has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Guidepoint Global. Dr. Sha has received personal compensation in the range of $500-$4,999 for serving as a Consultant for ExpertConnect. Dr. Sha has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Sha has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Forefront Collaborative. Dr. Sha has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for ReachMD. The institution of Dr. Sha has received research support from Biogen. The institution of Dr. Sha has received research support from Jannssen. The institution of Dr. Sha has received research support from UCB Pharma. The institution of Dr. Sha has received research support from Genentech. The institution of Dr. Sha has received research support from Eisai. The institution of Dr. Sha has received research support from Eli Lilly. Dr. Sha has received publishing royalties from a publication relating to health care.
Julio C. Rojas-Martinez, MD, PhD	The institution of Dr. Rojas-Martinez has received research support from NIH/NIA. The institution of Dr. Rojas-Martinez has received research support from Eli Lilly. The institution of Dr. Rojas-Martinez has received research support from Eisai. Dr. Rojas-Martinez has received research support from Roon, Healthcare. The institution of Dr. Rojas-Martinez has received research support from Amylyx.