2014 Annual Meeting | Clocks, Sleep, Brain Health and Disorders: Impact on Mechanism, Expression, and Treatment

Date Monday 04/28/14

Time 08:00 AM - 12:00 PM Add To Calendar

Session Format This program will be presented both in-person and online

On Demand This program is not expected to be available in the meeting's On Demand product.

Event Type Integrated Neuroscience

Director(s) Phyllis C. Zee, MD, PhD, Bradley V. Vaughn, MD, FAAN

Topic(s) Sleep

Learning Objectives Upon completion, participants will develop an understanding of the basic neurobiology of circadian and sleep systems, become familiar with neurological presentations of and treatment options for circadian disturbance, gain familiarity with the relationship of sleep and circadian rhythm issues to common neurodegenerative disorders, and learn to discuss how circadian rhythm and sleep issues may provide a diagnostic and therapeutic opportunity for patients with neurological disorders.

CME Available No CME available

Program Tracks Subspecialty in Focus

Recommended Audience Other, Trainee, General Neurologist, Specialist Neurologist, Non-neurologist

Teaching Styles Didactic, Interactive, Audience Participation, Other

Event Timeline
08:00 AM - 08:10 AM		Introduction Phyllis C. Zee, MD, PhD
08:00 AM - 12:00 PM	Abstract	001 - A Novel Capability for Monitoring Cerebral and Systemic Hemodynamics, ECG and Actigraphy During Sleep Vladimir Ivkovic, PhD
08:00 AM - 12:00 PM	Abstract	001 - Distinct Innervation Patterns of the Melanin Concentrating Hormone Neurons from the Basal Forebrain Structures Minjee Kim, MD
08:00 AM - 12:00 PM	Abstract	002 - Poor Sleep and White Matter Quality among Middle Aged Adults Kristine Yaffe, MD
08:00 AM - 12:00 PM	Abstract	002 - Comparing Periodic Limb Movements in Sleep in Subjects with and without Waking Paretic/Plegic Limbs Mark E. Dyken, MD
08:00 AM - 12:00 PM	Abstract	003 - Diffusion Tensor Imaging as a Biomarker for REM Sleep Behavior Disorder and Parkinson's Disease Matthew A. Brodsky, MD
08:00 AM - 12:00 PM	Abstract	003 - Exploring the neural circuitry of REM sleep behavior disorder in Parkinson's disease using functional MRI Samuel J. Bolitho, MD
08:00 AM - 12:00 PM	Abstract	004 - Investigating The Night To Night Variability Of REM Without Atonia In Parkinson's Disease Samuel J. Bolitho, MD
08:00 AM - 12:00 PM	Abstract	004 - Bright Light Therapy Improves Excessive Daytime Sleepiness Associated with Parkinson's Disease Aleksandar Videnovic, MD, MSc, FAAN
08:00 AM - 12:00 PM	Abstract	005 - Multiple Sclerosis Reported Fatigue: Obstructive Sleep Apnea & Abnormalities in Sleep Architecture in a Community Cohort Mark Gudesblatt, MD
08:00 AM - 12:00 PM	Abstract	005 - Antibodies against the cell adhesion molecule IgLON5 identify a novel tauopathy with NREM/REM parasomnia and sleep breathing disorder Charles Gaig
08:00 AM - 12:00 PM	Abstract	006 - Diazepam Useful in ESES Treatment Mirret M. El-Hagrassy, MD
08:00 AM - 12:00 PM	Abstract	007 - Sleep Abnormalities in Children with Dravet Syndrome Radhika Dhamija, MD
08:00 AM - 12:00 PM	Abstract	008 - Nocturnal Melatonin Regulation In Post-Traumatic Vegetative State: A Possible Role For Melatonin Supplementation? Pietro Guaraldi, MD, PhD
08:00 AM - 12:00 PM	Abstract	009 - The Efficacy of Gabapentin Enacarbil (GEn) in Adult Patients with Severe Primary Restless Legs Syndrome (RLS): Pooled Analyses From 3 Randomized Trials Daniel Lee, MD, FAAN
08:10 AM - 08:40 AM		Neurobiology of Sleep and Wake Regulation Clifford B. Saper, MD, PhD, FAAN
08:40 AM - 09:10 AM		The Role of Circadian Rhythm Dysfunction in Huntington Disease Jennifer Morton
09:10 AM - 09:45 AM		Bi-drectional Relationship Between Sleep, Circadian Rhythms, and Neurodegeneration David M. Holtzman, MD, FAAN
09:45 AM - 10:15 AM		Circadian Rhythm and Sleep in Epilepsy Mark S. Quigg, MD
10:15 AM - 10:30 AM		Questions and Answers
10:30 AM - 11:30 AM		Poster Rounds
11:30 AM - 12:00 PM		Data Blitz

Faculty Disclosures
Phyllis C. Zee, MD, PhD	Dr. Zee has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sanofi-Aventis. Dr. Zee has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Harmony Biosciences. Dr. Zee has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Jazz Pharmaceuticals Inc.. Dr. Zee has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eisai. The institution of Dr. Zee has received research support from National Institutes of Health. The institution of Dr. Zee has received research support from Vanda. Dr. Zee has received intellectual property interests from a discovery or technology relating to health care. Dr. Zee has received intellectual property interests from a discovery or technology relating to health care. Dr. Zee has received publishing royalties from a publication relating to health care.
Bradley V. Vaughn, MD, FAAN	Dr. Vaughn has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Medical Education Resources. Dr. Vaughn has received publishing royalties from a publication relating to health care. Dr. Vaughn has received publishing royalties from a publication relating to health care. Dr. Vaughn has a non-compensated relationship as a speaker/course director with AAN that is relevant to AAN interests or activities.
Mark S. Quigg, MD	Dr. Quigg has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cerebral Therapeutics. Dr. Quigg has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Cerebral Therapeutics. Dr. Quigg has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Finnigen and Harrison. Dr. Quigg has received research support from NIH. Dr. Quigg has received publishing royalties from a publication relating to health care.
David M. Holtzman, MD, FAAN	No disclosure on file
Clifford B. Saper, MD, PhD, FAAN	Dr. Saper has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for American Neurological Association. The institution of Dr. Saper has received research support from NIH. The institution of Dr. Saper has received research support from Mathers Foundation. The institution of Dr. Saper has received research support from Tsukuba University. Dr. Saper has received publishing royalties from a publication relating to health care. Dr. Saper has received publishing royalties from a publication relating to health care. Dr. Saper has a non-compensated relationship as a Treasurer with American Neurological Association that is relevant to AAN interests or activities.
Jennifer Morton	No disclosure on file
Stephen Sidney, MD, MPH	Dr. Sidney has nothing to disclose.
Kristine Yaffe, MD	Dr. Yaffe has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lilly. Dr. Yaffe has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Quintiles. Dr. Yaffe has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for Alector. The institution of Dr. Yaffe has received research support from NIH. The institution of Dr. Yaffe has received research support from DOD. The institution of Dr. Yaffe has received research support from Veterans Affairs.
	No disclosure on file
Yu-Tze Ng, MD, FRACP, FAAN	No disclosure on file
Jordan S. Dubow, MD	Dr. Dubow has received personal compensation in the range of $100,000-$499,999 for serving as a Consultant for Avadel Pharmaceuticals.
Gary Strangman	No disclosure on file
Lenore J. Launer, PhD	No disclosure on file
Mark E. Dyken, MD	No disclosure on file
Mark Gudesblatt, MD	No disclosure on file
Yaman Z. Eksioglu, MD, PhD	No disclosure on file
Josep O. Dalmau, MD, PhD, FAAN	Dr. Dalmau has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Astellas Research Institute of America. Dr. Dalmau has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen Research & Development . Dr. Dalmau has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for American Academy of Neurology. An immediate family member of Dr. Dalmau has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Dalmau has received research support from Sage Therapeutics. The institution of Dr. Dalmau has received research support from Edmond J.Safra Foundation . The institution of Dr. Dalmau has received research support from La Caixa Foundation. The institution of Dr. Dalmau has received research support from Spanish Ministry of Health (ISCIII). The institution of Dr. Dalmau has received research support from Euroimmun, Inc. Dr. Dalmau has received intellectual property interests from a discovery or technology relating to health care. An immediate family member of Dr. Dalmau has received intellectual property interests from a discovery or technology relating to health care. Dr. Dalmau has received intellectual property interests from a discovery or technology relating to health care. An immediate family member of Dr. Dalmau has received intellectual property interests from a discovery or technology relating to health care. Dr. Dalmau has received publishing royalties from a publication relating to health care. Dr. Dalmau has received publishing royalties from a publication relating to health care. Dr. Dalmau has received publishing royalties from a publication relating to health care.
Keith R. Edwards, MD, FAAN	No disclosure on file
Barbara Bumstead, NP	No disclosure on file
Mirret M. El-Hagrassy, MD	No disclosure on file
Kyoungbin Im	No disclosure on file
Samuel J. Bolitho, MD	No disclosure on file
Steven Xian, MD	No disclosure on file
Bruno Giometto, MD	Dr. Giometto has nothing to disclose.
Joan Santamaria, MD	Joan Santamaria, MD has nothing to disclose.
Marijean Buhse	No disclosure on file
Christopher C. LaGanke, MD	Dr. LaGanke has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for EMD Serono. Dr. LaGanke has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Dr. LaGanke has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Biogen. Dr. LaGanke has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Sanofi. Dr. LaGanke has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Novartis. Dr. LaGanke has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for GSK. Dr. LaGanke has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Serono EMD. Dr. LaGanke has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Genentech. Dr. LaGanke has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Bristol Myers Squibb. Dr. LaGanke has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for TG Therapeutics.
Myassar Zarif	No disclosure on file
Francesc R. Graus, MD	Dr. Graus has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for MedLink. Dr. Graus has received intellectual property interests from a discovery or technology relating to health care.
Angeles Contreras	No disclosure on file
William Ondo, MD	Dr. Ondo has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Cerevel. Dr. Ondo has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Supernus. Dr. Ondo has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amneal. Dr. Ondo has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Ipsen. Dr. Ondo has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for BlueRock. Dr. Ondo has received personal compensation in the range of $50,000-$99,999 for serving on a Speakers Bureau for Neurocrine. Dr. Ondo has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for ACADIA. Dr. Ondo has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Allergan. Dr. Ondo has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Kyowa Kirin. The institution of Dr. Ondo has received research support from Cerevel. The institution of Dr. Ondo has received research support from Sun. The institution of Dr. Ondo has received research support from SCION. The institution of Dr. Ondo has received research support from Harmony. Dr. Ondo has received publishing royalties from a publication relating to health care.
Radhika Dhamija, MD	Dr. Dhamija has nothing to disclose.
Erik K. St. Louis, MD	Dr. St. Louis has received publishing royalties from a publication relating to health care. Dr. St. Louis has received publishing royalties from a publication relating to health care.
Daniel Lee, MD, FAAN	No disclosure on file
Richard K. Kim, MD	No disclosure on file
Diego Garcia-Borreguero, MD	No disclosure on file
Gwendoline Shang	No disclosure on file
Patricia K. Coyle, MD, FAAN	Dr. Coyle has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Accordant. Dr. Coyle has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biogen. Dr. Coyle has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Bristol Myers Squibb. Dr. Coyle has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for Sanofi Genzyme. Dr. Coyle has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly and Company. Dr. Coyle has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Novartis. Dr. Coyle has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for GlaxoSmithKline. Dr. Coyle has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Horizon Therapeutics. Dr. Coyle has received personal compensation in the range of $500-$4,999 for serving as a Consultant for LabCorp. Dr. Coyle has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for EMD Serono. Dr. Coyle has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Mylan. Dr. Coyle has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amgen. Dr. Coyle has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Viatris. Dr. Coyle has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Biogen. The institution of Dr. Coyle has received research support from CorEvitas LLC. The institution of Dr. Coyle has received research support from Genentech/Roche. The institution of Dr. Coyle has received research support from NINDS. The institution of Dr. Coyle has received research support from Sanofi Genzyme. The institution of Dr. Coyle has received research support from Celgene.
Luis Bataller, MD	No disclosure on file
John E. Duda, MD	Dr. Duda has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Nature Publishing Group. The institution of Dr. Duda has received research support from Department of Veterans Affairs. The institution of Dr. Duda has received research support from Michael J. Fox Foundation. The institution of Dr. Duda has received research support from Innervace, Incorporated. The institution of Dr. Duda has received research support from National Institutes of Health.
Tomas Kalincik	Tomas Kalincik has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Roche. Tomas Kalincik has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sanofi Genzyme. Tomas Kalincik has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Novartis. Tomas Kalincik has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Merck. Tomas Kalincik has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biogen. Tomas Kalincik has received personal compensation in the range of $500-$4,999 for serving as a Consultant for National Health and Medical Research Council. Tomas Kalincik has received personal compensation in the range of $500-$4,999 for serving as a Consultant for MS Research Australia. Tomas Kalincik has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Tomas Kalincik has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Tomas Kalincik has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi Genzyme. Tomas Kalincik has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Tomas Kalincik has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Merck. Tomas Kalincik has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Janssen. Tomas Kalincik has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Bristol Myers Squibb. Tomas Kalincik has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for WebMD Global. Tomas Kalincik has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Novartis. Tomas Kalincik has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Biogen. Tomas Kalincik has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Sanofi Genzyme. Tomas Kalincik has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Teva. Tomas Kalincik has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for BioCSL. Tomas Kalincik has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Merck. Tomas Kalincik has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Eisai. The institution of Tomas Kalincik has received research support from Biogen. The institution of Tomas Kalincik has received research support from Novartis. The institution of Tomas Kalincik has received research support from Genzyme. The institution of Tomas Kalincik has received research support from Roche. The institution of Tomas Kalincik has received research support from Celgene. The institution of Tomas Kalincik has received research support from Merck. The institution of Tomas Kalincik has received research support from MSBase Foundation. The institution of Tomas Kalincik has received research support from ARSEP and EDMUS Foundations. The institution of Tomas Kalincik has received research support from MS Research Australia. The institution of Tomas Kalincik has received research support from National Health and Medical Research Council. The institution of Tomas Kalincik has received research support from Australian Research Council. The institution of Tomas Kalincik has received research support from MS Society. The institution of Tomas Kalincik has received research support from Trish Foundation. Tomas Kalincik has a non-compensated relationship as a scientific leadership group vice-chair with MSBase Foundation that is relevant to AAN interests or activities.
Alon Y. Avidan, MD, MPH, FAAN	Dr. Avidan has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Eisai. Dr. Avidan has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Avadel. Dr. Avidan has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Harmony. Dr. Avidan has received personal compensation in the range of $0-$499 for serving as a Consultant for Merck. Dr. Avidan has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Eisai. Dr. Avidan has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Harmony. Dr. Avidan has received publishing royalties from a publication relating to health care.
Suresh Kotagal, MD, FAAN	No disclosure on file
Aleksandar Videnovic, MD, MSc, FAAN	Dr. Videnovic has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion pharmaceuticals .
Matthew A. Brodsky, MD	Dr. Brodsky has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Medtronic. The institution of Dr. Brodsky has received research support from Boston Scientific.
Robert L. Rodnitzky, MD, FAAN	No disclosure on file
Alex Iranzo, MD	Dr. Iranzo has nothing to disclose.
Charles Gaig	No disclosure on file
Jody Corey-Bloom, MD, PhD, FAAN	Dr. Corey-Bloom has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for UniQure. Dr. Corey-Bloom has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Teva Pharmaceuticaks. Dr. Corey-Bloom has received personal compensation in the range of $10,000-$49,999 for serving as a Co-Director, HD-Net with Huntington Study Group.
Valerio Carelli, MD, PhD	Dr. Carelli has received personal compensation in the range of $0-$499 for serving as a Consultant for Chiesi Farmaceutici. Dr. Carelli has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Chiesi Farmaceutici.
Pietro Guaraldi, MD, PhD	No disclosure on file
Chiara La Morgia, MD	Dr. La Morgia has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Regulatory Pharmanet s.r.l. . Dr. La Morgia has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Santhera Pharmaceuticals. Dr. La Morgia has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Chiesi Farmaceutici s.p.a.. The institution of Dr. La Morgia has received research support from Italian Ministry of Health.
David S. Goldstein, MD, PhD	Dr. Goldstein has received publishing royalties from a publication relating to health care.
Pietro Cortelli, MD, FAAN	Dr. Cortelli has nothing to disclose.
Giovanna Calandra-Buonaura	No disclosure on file
Thomas E. Scammell, MD	Dr. Scammell has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for Takeda. Dr. Scammell has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for UpToDate. The institution of Dr. Scammell has received research support from Takeda.
Minjee Kim, MD	The institution of Dr. Kim has received research support from Genentech, Inc..
Vladimir Ivkovic, PhD	No disclosure on file
Heidi N. Beadnall, MD	Dr. Beadnall has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Beadnall has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Beadnall has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. The institution of Dr. Beadnall has received research support from MSBase Foundation.
Walter Royal III, MD	No disclosure on file
Timothy Cunniff, PharmD	Dr. Cunniff has received personal compensation for serving as an employee of Paragon Biosciences. Dr. Cunniff has stock in Harmony Biosciences. Dr. Cunniff has stock in Emalex Biosciences.
Stephen Wanaski, PhD	Dr. Wanaski has received personal compensation for serving as an employee of Paragon Biosciences. Dr. Wanaski has stock in Paragon Biosciences. Dr. Wanaski has stock in Emalex Biosciences.