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FOR IMMEDIATE RELEASE

Midlife Obesity Raises Risk of Alzheimer’s Disease Later

EMBARGOED FOR RELEASE UNTIL 3:00 P.M. PT, WEDNESDAY, APRIL 5, 2006

San Diego – People who are overweight or obese in their 40s have a greater risk of developing Alzheimer’s disease later in life, according to research that will be presented at the American Academy of Neurology 58th Annual Meeting in San Diego, Calif., April 1 – 8, 2006. For the study, researchers followed nearly 9,000 people over a period of up to 30 years. The study participants were evaluated for overweight and obesity by measuring skinfold thickness below the shoulder and at the back of the upper arm. Those with higher skinfold measurements in their 40s were more likely to develop Alzheimer’s disease than those with smaller skinfold measurements. Those in the highest group of shoulder skinfold measurements were nearly three times as likely to develop Alzheimer’s disease as those in the lowest group. For the arm measurements, those in the highest group were 2½ times as likely to develop Alzheimer’s as those in the lowest group. The results did not change when researchers took into account people with diabetes and other conditions that can increase the risk of Alzheimer’s disease. “These findings are important because obesity and overweight are treatable and modifiable risk factors,” said study author Rachel A. Whitmer, PhD, of the Kaiser Permanente Division of Research in Oakland, CA. “These results need to be confirmed, but these results suggest that keeping your weight down in midlife can help you remain mentally alert later on in life. And if we don’t control the current epidemic of obesity, the number of cases of dementia in the future may increase even higher than is currently predicted.” Whitmer noted that future studies are needed to examine the molecular mechanisms that link obesity and Alzheimer’s disease. The study was supported by a grant from the National Institutes of Health.

The American Academy of Neurology is the world's largest association of neurologists and neuroscience professionals, with 32,000 members. The AAN is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer's disease, stroke, migraine, multiple sclerosis, concussion, Parkinson's disease and epilepsy.

For more information about the American Academy of Neurology, visit AAN.com or find us on Facebook, Twitter, LinkedIn and YouTube.

Editor's Notes:Dr. Whitmer will present this research during a scientific poster session at 3:00 p.m. on Wednesday, April 5, in the Sails Pavilion of the San Diego Convention Center. She will be available for media questions during a briefing at 1:30 p.m., Wednesday, April 5 in the on-site Press Interview Room, room 16 B. All listed times are for Pacific Time (PT). AAN Press Room in the San Diego Convention Center April 1 - April 7, 2006 contact (619) 525-6207


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