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EMBARGOED FOR RELEASE UNTIL 4 PM ET, February 05, 2007

No More Seizures? New Drug Holds Promise for Epilepsy Patients

ST. PAUL, Minn – EMBARGOED FOR RELEASE UNTIL 4 P.M. ET, MONDAY, FEBRUARY 5, 2007 Media Contacts: Angela Babb, ababb@aan.com, (651) 695-2789 Robin Stinnett, rstinnett@aan.com, (651) 695-2763 No More Seizures? New Drug Holds Promise for Epilepsy Patients ST. PAUL, Minn – People with newly diagnosed epilepsy experienced few, if any, seizures while taking the drug levetiracetam as a single therapy, giving hope to epilepsy patients who don’t respond to or can’t tolerate existing treatments, according to a study published in the February 6, 2007 issue of Neurology®, the scientific journal of the American Academy of Neurology. For the multi-center, double-blind study, researchers assigned nearly 600 adults who had at least two seizures in the previous year to the drug levetiracetam or to controlled-release carbamazepine, a common epilepsy treatment. While levetiracetam is currently used as an add-on therapy by epilepsy patients, this is the first time its effectiveness as a single therapy has been tested through a clinical trial that provided class 1 evidence of efficacy as defined by the International League Against Epilepsy. The study found 73 percent of people taking levetiracetam and 72.8 percent of people receiving controlled-release carbamazepine remained seizure free for at least six months. “Both drugs produced equivalent seizure freedom rates in newly diagnosed epilepsy. Levetiracetam helps fill a need for safe and well-tolerated, easy-to-use epilepsy drugs, particularly because more than 30 percent of patients do not achieve seizure control with existing treatments,” said study author Martin Brodie, MD, with the Western Infirmary Epilepsy Unit in Glasgow, Scotland. Of those remaining seizure free for six months, the study also found 80.1 percent of those taking levetiracetam and 85.4 percent of those taking carbamazepine did so at the lowest dose level. “This trial confirms previous uncontrolled observations that most people with epilepsy will respond to their first epilepsy drug at low dosage,” said Brodie. Researchers say 14.4 percent of people taking levetiracetam withdrew from the study because of side effects such as drowsiness or dizziness, while 19.2 percent of people taking carbamazepine withdrew from the study with rash being the most common side effect. The study was supported by UCB Pharma.

The American Academy of Neurology, an association of more than 20,000 neurologists and neuroscience professionals, is dedicated to improving patient care through education and research. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Parkinson’s disease, ALS (Lou Gehrig’s disease), dementia, West Nile virus, and ataxia. For more information about the American Academy of Neurology, visit www.aan.com.


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