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Neurologist Says Stroke Among Neonates and Children Is Severely Under-Recognized

San Francisco, Calif. – There is a serious under-recognition of stroke in the neonate and child, and risk factors and appropriate treatment strategies remain largely unidentified, according to Donna Ferriero, MD, chief neurologist at the University of California-San Francisco Department of Neurology. Ferriero discusses risk factors leading to stroke in neonates and children as part of an October 24 briefing for science and health care writers. "Child Neurology: Discoveries and Practice" includes seven prominent child neurologists speaking on neurological disorders affecting children. Ferriero will present two papers recently published in Neurology, the scientific journal of the American Academy of Neurology, which outline an 11-year study of sinovenous thrombosis (stroke) in neonates, and stroke mortality data in children. Stroke in infancy and childhood occurs in one per 4000 live births and at least seven per 100,000 children a year, making these disorders more than twice as frequent as brain tumors in children, said Ferriero. Adverse outcomes include death in 6 percent, stroke recurrence in 20 to 35 percent of children, and neurological deficits or seizures in over two-thirds of survivors. Because of age-related differences only minimal research data derived from adult stroke studies, including the risks and benefits of treatments, can be extrapolated to neonates and children. Ferriero said barriers prevent needed investigation into the cause and treatment of neonatal and childhood stroke, including: * The perception that stroke in neonates and children is exceedingly rare and therefore there isn''''''''t a pressing need to study these populations. * Lack of awareness of neonatal and childhood stroke results in delayed and missed diagnosis, and non-standardized approaches to investigation and management in individual patients. * Neonatal stroke is especially under-diagnosed, and the timing and risk factors are difficult to determine because they may occur prenatally. It is necessary to work with obstetricians to develop primary prevention strategies. * Most animal studies are not critically designed to test hypotheses based on stages of maturity and development as they relate to stroke mechanisms. * There are insufficient numbers of investigators trained in translational and clinical research in pediatric stroke. The American Academy of Neurology, the AAN Education & Research Foundation, the Child Neurology Society and the Child Neurology Foundation are sponsoring the briefing.

The American Academy of Neurology is the world's largest association of neurologists and neuroscience professionals, with 32,000 members. The AAN is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer's disease, stroke, migraine, multiple sclerosis, concussion, Parkinson's disease and epilepsy.

For more information about the American Academy of Neurology, visit or find us on Facebook, Twitter, LinkedIn and YouTube.

Editor's Notes:The Child Neurology Society is a medical specialty association with 1,400 academic and practicing pediatric neurologists as members worldwide. Its mission is to ensure and maintain excellence in patient care, education, training, research and advocacy.

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