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EMBARGOED FOR RELEASE UNTIL 4 PM ET, August 27, 2008

Even Without Dementia, Mental Skills Decline Years Before Death

ST. PAUL, Minn. – A new study shows that older people’s mental skills start declining years before death, even if they don’t have dementia. The study is published in the August 27, 2008, online issue of Neurology®, the medical journal of the American Academy of Neurology. “These changes are different and separate from the changes in thinking skills that occur as people get older,” said study author Valgeir Thorvaldsson, MSc, of Göteberg University in Sweden. “We found accelerated changes in people’s mental skills that indicated a terminal decline phase years before death.” The start of the decline is different for various cognitive abilities. Perceptual speed, which measures how quickly people can compare figures, begins declining nearly 15 years before death. Spatial ability starts declining nearly eight years before death. And verbal ability starts declining about six-and-a-half years before death. The study involved 288 people with no dementia who were followed from age 70 to death, with an average age at death of 84. The participants’ mental skills were measured up to 12 times over a period of 30 years, and they were evaluated to make sure they had not developed dementia. A number of factors may explain this terminal decline in mental skills, Thorvaldsson said. “Cardiovascular conditions such as heart disease or dementia that is too early to be detected could be factors,” he said. “Increased health problems and frailty in old age often lead to inactivity, and this lack of exercise and mental stimulation could accelerate mental decline.” Thorvaldsson noted that verbal abilities declined sharply in the terminal phase and did not decline significantly due to age only. “This indicates that people remain stable in their verbal abilities unless they are experiencing disease processes that also increase their mortality risk,” he said. “A change in verbal ability might therefore be considered a critical marker for degeneration in health in older people.” The study was supported by the Swedish Brain Power and the Swedish Council for Working Life and Social Research.

The American Academy of Neurology, an association of more than 21,000 neurologists and neuroscience professionals, is dedicated to improving patient care through education and research. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as stroke, Alzheimer’s disease, epilepsy, Parkinson’s disease, and multiple sclerosis. For more information about the American Academy of Neurology, visit www.aan.com.


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