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August 28, 2014: Miller Fisher Syndrome and Ophthalmoplegia

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August 28, 2014

Miller Fisher syndrome (MFS), a variant of Guillain-Barré syndrome (GBS), is characterized by a triad of ataxia, areflexia and ophthalmoplegia. It is associated with presence of GQ1b antibodies in CSF. The GQ1b ganglioside is a cell surface component concentrated in the paranodal regions of the third, fourth and sixth cranial nerves. The anti-GQ1b-antibody is more commonly detected in GBS and MFS with ophthalmoplegia than without. Patients with MFS usually have symmetrical and bilateral ophthalmoplegia, but this condition can be seen unilaterally.

References

  1. Evliyaoglu, F, Karadag R, Burakgazi AZ. Ocular neuropathy in peripheral neuropathies. Muscle Nerve 2012;46: 681-686.

Submitted by: Sweta Goel, MD, neurology resident, Department of Neurology, University of Texas, Houston

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