August 28, 2014: Miller Fisher Syndrome and Ophthalmoplegia

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August 28, 2014

Miller Fisher syndrome (MFS), a variant of Guillain-Barré syndrome (GBS), is characterized by a triad of ataxia, areflexia and ophthalmoplegia. It is associated with presence of GQ1b antibodies in CSF. The GQ1b ganglioside is a cell surface component concentrated in the paranodal regions of the third, fourth and sixth cranial nerves. The anti-GQ1b-antibody is more commonly detected in GBS and MFS with ophthalmoplegia than without. Patients with MFS usually have symmetrical and bilateral ophthalmoplegia, but this condition can be seen unilaterally.


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Submitted by: Sweta Goel, MD, neurology resident, Department of Neurology, University of Texas, Houston

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