December 10, 2013: Garcin syndrome

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December 10, 2013

Garcin Syndrome (or Guillain-Alajouanine-Garcin syndrome), first described in 1926 as "syndrome paralytique unilateral global des nerfs crannies," consists of multiple cranial nerve palsies (at least 7 ipsilateral cranial nerves) in the absence of long tract signs or raised intracranial pressure [1,2].  This rare progressive condition is generally associated with skull based malignant osteoclastic lesions but has also been described with pachymeningitis secondary to otitis media, rhinocerebral mucormycosis, hypertrophic pachymeningitis, lymphomatous meningitis, carcinomatous leptomeningitis, and giant internal carotid aneurysm.


  1. Guillan R, Alajouanine TH, Garcin R. Le syndrom paralytique unilateral global des nerfs craniens. Bull Med Hop (Paris) 1926; 50:456.
  2. Bignas B. Tumors of the base of the skull, vol. 16. In: Vinken PJ, Bruyn GW, eds. Handbook of Clinical Neurology. Amsterdam: Elsevier Science, 1974:180-183.

Submitted by: Soaham Dilip Desai, MBBS, MD, DM, Consultant Neurologist, Shree Krishna Hospital, Karamsad, Gujarat, India.

Dr. Desai reports no disclosures.

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