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June 28, 2016: Morning glory syndrome

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June 28, 2016

Morning glory syndrome

Morning glory disc anomaly (MGDA) is a congenital malformation of the optic nerve. The dysplastic optic disc has a characteristic fundoscopic appearance, with a conical excavation surrounded by peripapillary atrophy, pigmentation and glial tissue overlying the emerging, straight retinal vessels1. It is named after its resemblance to the morning glory flower1. When identified, MGDA should prompt brain and vascular imaging as it is associated with abnormalities of CNS development, including transphenoidal basal encephalocele and neurofibromatosis type 21,3. In 45% of cases, MGDA is associated with cerebrovascular abnormalities, including moyamoya2,3.    

  1. Brodsky, M.C. Congenital Optic Disc Anomalies. In: Pediatric Neuro-ophthalmology, 2nd ed. New York: Springer; 2010.
  2. Lenhart PD, Lambert SR, Newman NJ, et al. Intracranial vascular anomalies in patients with morning glory disk anomaly. Am J Ophthalmol 2006; 142: 644-650.
  3. Lee, BJ and Traboulsi, EI.Update on the Morning Glory Disc Anomaly. Ophthalmic Genetics 2008; 29: 47-52.

Submitted by Oana Dumitrascu, MD, MS, Resident Physician, Department of Neurology, Cedars-Sinai Medical Center.

Dr. Dumitrascu reports no disclosures.

For more clinical pearls and other articles of interest to neurology trainees, visit Neurology.  Listen to this week's Neurology Podcast.

 

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