Abstract Details

Title Association of Admission Serum Low-density-Lipoprotein With Stroke Etiology Of Large-Vessel-Disease And Functional Outcome At Discharge

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P1 - Poster Session 1 (12:00 PM-1:00 PM)

Poster/Presentation
Number 4-012

Objective We investigated if the elevated Low-density-Lipoprotein (LDL) level obtained on the first day of admission of patients with an acute ischemic stroke is associated with the stroke etiology of large-vessel-disease (LVD) and poor functional outcome at discharge.

Background Elevated LDL is an established risk factor for cardiovascular disease.

Design/Methods We performed a retrospective chart review of patients evaluated for acute strokes at a comprehensive stroke center from July 2014 to March 2018. Patients included in the study were all given intravenous alteplase, had blood drawn for LDL on the first day of admission and had confirmation of a new stroke on neuroimaging during hospitalization. Stroke etiology was classified into large-vessel-disease (LVD) and non-large-vessel-disease (NLVD), according to the TOAST criteria. A binary logistic regression analysis was performed, controlling for age, sex, presenting NIHSS, presenting mean-arterial-pressure and hemoglobin-A1C with the serum LDL level as the predictor. The primary outcome was the association of serum LDL with the LVD stroke subtype. The secondary outcome was the association of serum LDL with the functional outcome at discharge. Good outcome was defined as a modified rankin scale (mRS) of 0-2 and a poor outcome as mRS of 3-6, upon discharge.

Results 142 patients met the inclusion criteria. The mean age was 63.99±14 years. The mean serum LDL was 101.77±39 mg/dL. In the logistic regression model, higher serum LDL on admission was significantly associated with the LVD stroke subtype (117.89±37 vs.99.59±39; OR, 1.02; 95% CI, 1.01-1.04; P 0.041). High serum LDL levels on admission were also associated with poor outcome (mRS ≥3) on discharge (OR, 1.02; 95% CI, 1.01-1.03; P 0.036).

Conclusions An admission LDL level showed a significant difference between LVD and NLVD strokes. Our study also found that a high serum LDL on admission is associated with a poor functional outcome upon discharge.

Authors/Disclosures
Taha Nisar, MD (Rutgers New Jersey Medical School) PRESENTER	Dr. Nisar has nothing to disclose.