Abstract Details

Title Case Report: Deep Brain Stimulation targeting the Globus Pallidus internus for Parkinson’s disease and Tourette syndrome

Topic Movement Disorders

Presentation(s) P1 - Poster Session 1 (12:00 PM-1:00 PM)

Poster/Presentation
Number 3-008

Objective

To report a patient with Parkinson’s disease (PD) and Tourette syndrome, well managed with Deep Brain Stimulation (DBS) targeting the Globus Pallidus internus (GPi).

Background DBS targeting the GPi is effective in some cases of intractable Tourette syndrome. However, The GPi DBS parameters used for Tourette syndrome is usually different from those used for Parkinson's disease (PD), with low frequency, high pulse width stimulation being most effective.

Design/Methods Case report with literature review.

Results We present a patient with PD and Tourette syndrome. Patient takes aripiprazole for Tourette syndrome and obsessive compulsive disorder, which unfortunately worsens his parkinsonism. After GPi DBS placement, with high frequency (130Hz), low pulse width (60 microseconds) settings, we achieved good control of his parkinsonian symptoms. Interestingly, his Tourette syndrome symptoms also improved with decreased tics. To our knowledge this is the first case report on DBS targeting GPi in a patient with both PD and Tourette syndrome.

Conclusions Low pulse width, high frequency DBS stimulation may be helpful for both PD and Tourette syndrome.

Authors/Disclosures
Qiang J. Zhang, MD (University of Iowa, Hospitals and Clinics) PRESENTER	The institution of Dr. Zhang has received research support from NIH/NIA.
Teri R. Thomsen, MD (University of Iowa)	Dr. Thomsen has nothing to disclose.