Abstract Details

Title Sleep Disordered Breathing in Pediatric Multiple Sclerosis

Topic Sleep

Presentation(s) P1 - Poster Session 1 (12:00 PM-1:00 PM)

Poster/Presentation
Number 5-002

Objective To evaluate for sleep disordered breathing in youth with MS compared to healthy controls (HC).

Background Adults with Multiple Sclerosis (MS) are reported to have high rates of sleep disorders, correlating with daytime fatigue. In pediatric MS, high rates of fatigue are also reported. It is unknown if these children are at higher risk for sleep disordered breathing (SDB) as a potential contributor to daytime fatigue.

Design/Methods Prospective observational study including consecutive patients with a diagnosis of MS (onset prior to 18 years of age), evaluated at the Pediatric MS and Neuroinflammatory Disorders clinic, Hospital for Sick Children, Canada from June 2017 to November 2018. Age and sex-matched healthy controls were included from a concurrent sleep study. Parents completed the Pediatric Sleep Questionnaire. Positive answers with >0.33 suggest a risk for pediatric sleep related breathing disorder. The total sleep-disordered breathing score is divided into breathing, daytime sleepiness, behavior and “other symptoms” subscores.

Results 16% of MS patients (N=45, 29F, 16.9(1.5) y.o.) and 8% of healthy controls HC (N=25, 21F, 16.7(1.3) y.o.) met threshold for SDB total score (SDB raw score mean 3.89 (MS) and 2.28 (HC) (p=0.024)). Behavior subscore threshold reached in 47% of MS patients and 8% in the HC group (mean behavior raw score 2.13 (MS), 0.52 (HC), p<0.001). Breathing, daytime sleepiness and other subscore were not different between MS and HC (breathing raw score mean 0.42 (MS), 0.52 (HC) (p=0.93), daytime sleepiness raw score mean 0.80 (MS), 1.16 (HC) (p=0.49), other raw score mean 0.33 (MS), 0.08 (HC) (p=0.06)).

Conclusions Total sleep disordered breathing was higher in youth with MS than healthy controls, with the behavioral subscore possibly accounting for differences in total sleep disordered breathing scores in this population. These findings should be confirmed with objective testing, and could represent a target for future interventional strategies.

Authors/Disclosures
Michelle J. Jaeggi, MD (The Hospital for Sick Children) PRESENTER	Dr. Jaeggi has nothing to disclose.
Stephanie Grover, MSc, CCRP (The Hospital for Sick Children)	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Shelly K. Weiss, MD (HSC)	No disclosure on file
E. Ann Yeh, MD, MA, FRCPC (Hospital for Sick Children)	Dr. Yeh has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Pipeline therapeutics. Dr. Yeh has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Dr. Yeh has received personal compensation in the range of $0-$499 for serving as an officer or member of the Board of Directors for SCN. Dr. Yeh has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. The institution of Dr. Yeh has received research support from CIHR. The institution of Dr. Yeh has received research support from National MS Society. The institution of Dr. Yeh has received research support from SickKids Foundation. The institution of Dr. Yeh has received research support from MSSC. The institution of Dr. Yeh has received research support from Garry Hurvitz Foundation. The institution of Dr. Yeh has received research support from Leong Centre. The institution of Dr. Yeh has received research support from OMSLife. The institution of Dr. Yeh has received research support from Canada's Drug Agency. Dr. Yeh has received personal compensation in the range of $0-$499 for serving as a Author with Medscape. Dr. Yeh has a non-compensated relationship as a Editorial Board with Neurology that is relevant to AAN interests or activities. Dr. Yeh has a non-compensated relationship as a Editorial Board with MSJ that is relevant to AAN interests or activities.