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Abstract Details

Sleep Problems and Risk of All-cause Cognitive Decline or Dementia: An Updated Systematic Review and Meta-analysis
Sleep
P1 - Poster Session 1 (12:00 PM-1:00 PM)
5-010
To conduct an updated systematic review and meta-analysis of association between sleep and all-cause cognitive disorders.
Lines of evidence showed that sleep disorders could contribute to cognitive decline or dementia (cognitive disorders) and might serve as a promising target for dementia prevention. However, the robustness of the evidence base might be jeopardized by sources of bias, such as high heterogeneity, recall bias, varying definitions of sleep-related exposures, and small-sample effect. In the past two years, large amounts of cohort studies have sprung up to explore the longitudinal influences of sleep-related exposures on incident risks of cognitive disorders, which necessitates an updated systematic review and meta-analysis.

PubMed and EMBASE were searched from inception to Feb 18, 2019. Cohort studies exploring longitudinal associations of sleep with cognitive decline or dementia were included. The multivariable-adjusted effect estimates were pooled by random-effects models, with credibility assessment. REMR model was used to conduct the dose-response meta-analysis for sleep duration.

11,155 reports were searched and 51 eligible cohorts with 15 sleep problems were included for our meta-analyses. Ten types of sleep disorders, including six (insomnia, fragmentation, daytime dysfunction, prolonged latency, rapid eye movement sleep behavior disorder, and excessive time in bed) with moderate-to-high levels of evidence, were linked to higher risk of all-cause cognitive disorders. Furthermore, a U-shaped relationship was revealed for the associations with sleep duration.

Sleep management might serve as a promising target for dementia prevention.

Authors/Disclosures
Wei Xu
PRESENTER
No disclosure on file