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Abstract Details

Clinical Characteristics of Early-Onset Parkinson Disease in Mayo Clinic Population
Movement Disorders
P6 - Poster Session 6 (5:30 PM-6:30 PM)

The causes of EOPD remain undefined; the clinical course and phenotypical characteristics of EOPD are different than those of late onset Parkinson disease. Unfortunately, there is still a gap of knowledge on EOPD. 

To describe the demographic pattern and the clinical characteristics of the patients with Early Onset Parkinson's Disease (EOPD) at the Mayo Clinic.

We retrieved all the patients with EOPD that have visited the Mayo Clinic from 1990 to 2022 using Mayo Data Explorer (MDE). We included patients with a diagnosis of Parkinson’s disease (PD) at or before the age of 50 years old (according to the current Movement Disorder Society (MDS) recommendation on EOPD). In addition, we assessed the clinical features of those who were included. 

A total of 838 (518 males and 320 females) patients with EOPD were included with a mean age at symptoms onset of 40.6 ± 6.7 years. Overall, 13.6% had a family history of PD, with only 4.5% with genetic testing. Resting tremor was reported in 84.8%, bradykinesia in 85.9%, rigidity in 81.3% and postural instability in 13.1%. Dyskinesias were documented in 44.4% with a mean time from PD diagnosis of 10.5 ± 6.2 years. Cognitive impairment was reported in 19.3% of patients with a mean time from PD diagnosis of 16.8 ± 14.3 years.

We described the clinical characteristics of the EOPD in a large cohort. EOPD displays distinct clinical patterns regarding symptoms, progression, cognitive decline and response to medications. These differences may reflect multifactorial causes such as pathophysiological backgrounds and genetic, environmental, or age-related factors.

Khaled Ghoniem, MD (Mayo Clinic)
Dr. Ghoniem has nothing to disclose.
Jessie Jacobson, DO (BROOKE ARMY MEDICAL CENTER) Dr. Jacobson has nothing to disclose.
Aidan Mullan (Mayo Clinic) No disclosure on file
Pierpaolo Turcano, MD (Mayo Clinic) Dr. Turcano has nothing to disclose.
Emanuele Camerucci, MD (Kansas University Medical Center) Dr. Camerucci has nothing to disclose.
Cole D. Stang Mr. Stang has nothing to disclose.
James H. Bower, MD, MSc, FAAN (Mayo Clinic) The institution of Dr. Bower has received research support from Abbvie.
Rodolfo Savica, MD, PhD, FAAN (Mayo Clinic) The institution of Dr. Savica has received research support from ACADIA Pharmaceuticals, Inc.