Log In

Forgot Password?

OR

Not a member? Continue as a nonmember.

Become a Member

By becoming a member of the AAN, you can receive exclusive information to help you at every stage of your career. Benefits include:

Join Now See All Benefits

Loading... please wait

Abstract Details

Data-driven phenotypic clustering of Parkinson’s disease patients seeking deep brain stimulation
Movement Disorders
P6 - Poster Session 6 (5:30 PM-6:30 PM)
5-008
RAD-PD is a longitudinal quality improvement registry that systematically characterizes participants through patient reported outcome measures and clinician administered scales, with the overarching goal of improving outcomes from deep brain stimulation (DBS) in PD. Multiple investigations demonstrate that DBS improves motor function and quality of life (QoL). Less is understood about non-motor outcomes and determinants. 

To identify unique phenotypic clusters amongst participants in RAD-PD (Registry for the Advancement of Deep Brain Stimulation in Parkinson’s Disease). 

A variety of demographic/social, disease-related, motor, non-motor, quality of life, and treatment-related datapoints are captured in RAD-PD.  Continuous data variables from participants with complete pre-operative assessments were analyzed using R software. A pairs plot correlation analysis, principal component analysis (PCA) and hierarchical clustering analysis (HCA) with normalized data were conducted.  

Data from 133 subjects were included. Amongst 32 categories of RAD-PD data covering demographic/disease (n=5), non-motor (n=18), motor (n=3), cognitive (n=3) and QoL (n=3) variables, all 3 QoL scale scores were strongly correlated with each other (r=0.47-0.64, p<0.0001), and were otherwise most highly correlated (r>0.4) with  measures of depression, anxiety, sleep/fatigue, NMSS total, mood/cognition, IADLs, and MDS-UPDRS part 2. Motor and disease-related variables did not strongly correlate with other variables. PCA revealed two dimensions that together explain 38.7% of the variance in the data, driven mainly by quality of life, NMSS domain/total scores, and QUIP-RS subscores/total scores. HCA classified individuals into two groups that were differentiated based on non-motor (NMSS and ICD scores), cognitive, and QoL features. 

While recommendations for DBS in PD are often driven by motor disease features, QoL and non-motor symptoms are prominent features that are closely related and can be combined to classify phenotypic clusters. Such data-driven classifications can be used in the RAD-PD cohort for novel outcomes analyses and predictive modeling.  

Authors/Disclosures
Joohi Jimenez Shahed, MD (Icahn School of Medicine at Mount Sinai)
PRESENTER
Dr. Jimenez Shahed has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Bracket Global LLC. Dr. Jimenez Shahed has received personal compensation in the range of $500-$4,999 for serving as a Consultant for St. Jude Medical, Inc. Dr. Jimenez Shahed has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Teva. Dr. Jimenez Shahed has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Medtronic. Dr. Jimenez Shahed has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abbvie. Dr. Jimenez Shahed has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alpha Omega. Dr. Jimenez Shahed has received personal compensation in the range of $500-$4,999 for serving as a Consultant for RegenXBio. Dr. Jimenez Shahed has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Praxis. Dr. Jimenez Shahed has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Kyowa Kirin. Dr. Jimenez Shahed has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amneal. Dr. Jimenez Shahed has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for BlueRock Therapeutics. Dr. Jimenez Shahed has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for PhotoPharmics. The institution of Dr. Jimenez Shahed has received research support from Michael J Fox Foundation. The institution of Dr. Jimenez Shahed has received research support from Amneal. The institution of Dr. Jimenez Shahed has received research support from Annovis. The institution of Dr. Jimenez Shahed has received research support from SAGE. Dr. Jimenez Shahed has received personal compensation in the range of $500-$4,999 for serving as a Faculty with Movement Disorders Society. Dr. Jimenez Shahed has received personal compensation in the range of $500-$4,999 for serving as a Faculty with American Academy of Neurology. Dr. Jimenez Shahed has received personal compensation in the range of $500-$4,999 for serving as a Grant Reviewer with Parkinson Foundation. Dr. Jimenez Shahed has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant on Research Grant with Florida Atlantic University. Dr. Jimenez Shahed has received personal compensation in the range of $0-$499 for serving as a Speaker with Tourette Association of America. Dr. Jimenez Shahed has received personal compensation in the range of $5,000-$9,999 for serving as a Speaker with NACCME.
Arthur Berg The institution of Arthur Berg has received research support from U.S. Army Medical Research and Development Command . The institution of Arthur Berg has received research support from NIH. The institution of Arthur Berg has received research support from Health Resources and Services Administration . The institution of Arthur Berg has received research support from Penn State Department of Family Medicine. The institution of Arthur Berg has received research support from Penn State Department of Surgery.
Michele K. York, PhD, ABPP-CN (Baylor College of Medicine) Dr. York has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for RAD-PD. The institution of Dr. York has received research support from Michael J. Fox Foundation. The institution of Dr. York has received research support from NIH. The institution of Dr. York has received research support from Takeda.
Jason Schwalb (Henry Ford Medical Group) Mr. Schwalb has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for NeuroPoint Alliance. Mr. Schwalb has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Jackson & Campbell, PC. The institution of Mr. Schwalb has received research support from StimWave.
James Kirk James Kirk has nothing to disclose.
Mustafa S. Siddiqui, MD, FAAN Dr. Siddiqui has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Boston Scientific Neuromodulation. Dr. Siddiqui has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Abbvie. Dr. Siddiqui has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for United States Department of Justice. The institution of Dr. Siddiqui has received research support from Boston Scientific Neuromodulation. The institution of Dr. Siddiqui has received research support from Abbvie. Dr. Siddiqui has received research support from Michael J. Fox Foundation. The institution of Dr. Siddiqui has received research support from National Institute of Health .
James McInerney James McInerney has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Medtronic.